University of Tsukuba

About: University of Tsukuba is a education organization based out in Tsukuba, Ibaraki, Japan. It is known for research contribution in the topics: Population & Gene. The organization has 36352 authors who have published 79483 publications receiving 1934752 citations. The organization is also known as: Tsukuba daigaku & Tsukuba University.

Local and Remote Responses to Excessive Snow Mass over Eurasia Appearing in the Northern Spring and Summer Climate A Study with the MRI * GCM

Abstract: The effect of excessive snow mass over the Eurasian continent on the spring and summer climate is investigated by using the MRI * GCM. The ensemble mean of the four runs (SNOW runs) with the excessive snow mass of 5 cm (water equivalent) at the beginning of March over the snow cover area of the continent is compared with that of the control runs, to deduce the effect of the snow mass on the climatic parameters in the later seasons. The main results are summarized as follows: (1) In spring, the albedo effect is dominated in the lower latitudes particularly over the Tibetan Plateau. The reduced net radiation by the anomalous snow cover balances the reduced surface sensible and latent heat fluxes, which account for the significant decrease of surface temperature, cloudiness and total diabatic heating over there in the SNOW runs. (2) In summer, in contrast, the snow-hydrological effect is significant, particularly in the mid-latitudes. The increase of ground wetness in the SNOW runs causes anomalous cooling and higher pressure near the surface. A moderate signal of the weakened Asian summer monsoon is also obtained. However, the increase of evaporation activates cumulus convection, which partly compensates for the decrease of total diabatic heating by the cooling near the surface. This evaporation/convection feedback seems to work, on the other hand, to sustain the increased ground wetness throughout the summer. (3) The atmospheric teleconnection patterns induced by the anomalous snow cover over the Tibetan Plateau and east Asia significantly appear over the north Pacific and the North American continent in spring through late summer. These anomalous circulations cause the considerable decrease of surface temperature over the northeastern part of North America. (4) The implication of these results for the Ice Age issue is also briefly discussed.

Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms

Abstract: Cohesin is a multimeric protein complex that is involved in the cohesion of sister chromatids, post-replicative DNA repair and transcriptional regulation. Here we report recurrent mutations and deletions involving multiple components of the cohesin complex, including STAG2, RAD21, SMC1A and SMC3, in different myeloid neoplasms. These mutations and deletions were mostly mutually exclusive and occurred in 12.1% (19/157) of acute myeloid leukemia, 8.0% (18/224) of myelodysplastic syndromes, 10.2% (9/88) of chronic myelomonocytic leukemia, 6.3% (4/64) of chronic myelogenous leukemia and 1.3% (1/77) of classical myeloproliferative neoplasms. Cohesin-mutated leukemic cells showed reduced amounts of chromatin-bound cohesin components, suggesting a substantial loss of cohesin binding sites on chromatin. The growth of leukemic cell lines harboring a mutation in RAD21 (Kasumi-1 cells) or having severely reduced expression of RAD21 and STAG2 (MOLM-13 cells) was suppressed by forced expression of wild-type RAD21 and wild-type RAD21 and STAG2, respectively. These findings suggest a role for compromised cohesin functions in myeloid leukemogenesis.

Endothelial Progenitors: A Consensus Statement on Nomenclature.

Abstract: Endothelial progenitor cell (EPC) nomenclature remains ambiguous and there is a general lack of concordance in the stem cell field with many distinct cell subtypes continually grouped under the term “EPC.” It would be highly advantageous to agree on standards to confirm an endothelial progenitor phenotype and this should include detailed immunophenotyping, potency assays, and clear separation from hematopoietic angiogenic cells which are not endothelial progenitors. In this review, we seek to discourage the indiscriminate use of “EPCs,” and instead propose precise terminology based on defining cellular phenotype and function. Endothelial colony forming cells and myeloid angiogenic cells are examples of two distinct and well-defined cell types that have been considered EPCs because they both promote vascular repair, albeit by completely different mechanisms of action. It is acknowledged that scientific nomenclature should be a dynamic process driven by technological and conceptual advances; ergo the ongoing “EPC” nomenclature ought not to be permanent and should become more precise in the light of strong scientific evidence. This is especially important as these cells become recognized for their role in vascular repair in health and disease and, in some cases, progress toward use in cell therapy.