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Institution

University of Tsukuba

EducationTsukuba, Ibaraki, Japan
About: University of Tsukuba is a education organization based out in Tsukuba, Ibaraki, Japan. It is known for research contribution in the topics: Population & Gene. The organization has 36352 authors who have published 79483 publications receiving 1934752 citations. The organization is also known as: Tsukuba daigaku & Tsukuba University.


Papers
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Proceedings ArticleDOI
18 Sep 1993
TL;DR: A six degree-of-freedom force reflective master manipulator which has a pen-shaped grip has been developed and is exemplified in interactive deformation of a free-form surface.
Abstract: The development of a pen-based force display and its application to the direct manipulation of a free-form surface are described. A six degree-of-freedom force reflective master manipulator which has a pen-shaped grip has been developed. The system uses two three degree-of-freedom manipulators. Both ends of the pen are connected to these manipulators. The hardware of the force display is small and light-weight. The performance of the force display is exemplified in interactive deformation of a free-form surface. >

310 citations

Journal ArticleDOI
TL;DR: These rice-based mucosal vaccines offer a highly practical and cost-effective strategy for orally vaccinating large populations against mucosal infections, including those that may result from an act of bioterrorism.
Abstract: Capable of inducing antigen-specific immune responses in both systemic and mucosal compartments without the use of syringe and needle, mucosal vaccination is considered ideal for the global control of infectious diseases. In this study, we developed a rice-based oral vaccine expressing cholera toxin B subunit (CTB) under the control of the endosperm-specific expression promoter 2.3-kb glutelin GluB-1 with codon usage optimization for expression in rice seed. An average of 30 μg of CTB per seed was stored in the protein bodies, which are storage organelles in rice. When mucosally fed, rice seeds expressing CTB were taken up by the M cells covering the Peyer's patches and induced CTB-specific serum IgG and mucosal IgA antibodies with neutralizing activity. When expressed in rice, CTB was protected from pepsin digestion in vitro. Rice-expressed CTB also remained stable and thus maintained immunogenicity at room temperature for >1.5 years, meaning that antigen-specific mucosal immune responses were induced at much lower doses than were necessary with purified recombinant CTB. Because they require neither refrigeration (cold-chain management) nor a needle, these rice-based mucosal vaccines offer a highly practical and cost-effective strategy for orally vaccinating large populations against mucosal infections, including those that may result from an act of bioterrorism.

310 citations

Journal ArticleDOI
TL;DR: Using tetramethylammonium hydroxide thermochemolysis, lignin degradation by two insect species, the Asian longhorned beetle and the Pacific dampwood termite, is shown and a single species of fungus is identified in the Fusarium solani/Nectria haematococca species complex that may be contributing to wood degradation.
Abstract: The aromatic polymer lignin protects plants from most forms of microbial attack Despite the fact that a significant fraction of all lignocellulose degraded passes through arthropod guts, the fate of lignin in these systems is not known Using tetramethylammonium hydroxide thermochemolysis, we show lignin degradation by two insect species, the Asian longhorned beetle (Anoplophora glabripennis) and the Pacific dampwood termite (Zootermopsis angusticollis) In both the beetle and termite, significant levels of propyl side-chain oxidation (depolymerization) and demethylation of ring methoxyl groups is detected; for the termite, ring hydroxylation is also observed In addition, culture-independent fungal gut community analysis of A glabripennis identified a single species of fungus in the Fusarium solani/Nectria haematococca species complex This is a soft-rot fungus that may be contributing to wood degradation These results transform our understanding of lignin degradation by wood-feeding insects

310 citations

Journal ArticleDOI
TL;DR: Nonfasting serum triglycerides predict the incidence of coronary heart disease among Japanese men and women who possess low mean values of total cholesterol, and adjustment for high density lipoprotein cholesterol suggests an independent role of triglycerides on the coronaryHeart disease risk.
Abstract: To examine the relation of triglycerides with coronary heart disease among populations with low mean total cholesterol, the authors conducted a 15.5-year prospective study ending in 1997 of 11,068 Japanese aged 40-69 years (4,452 men and 6,616 women with mean total cholesterol = 4.73 mmol/liter and 5.03 mmol/liter, respectively), initially free of coronary heart disease or stroke. There were 236 coronary heart disease events comprising 133 myocardial infarctions, 68 angina pectoris events, and 44 sudden cardiac deaths. The coronary heart disease incidence was greater in a dose-response manner across increasing quartiles of nonfasting triglycerides for both sexes. The multivariate relative risk of coronary heart disease adjusting for coronary risk factors and time since last meal associated with a 1-mmol/liter increase in triglycerides was 1.29 (95% confidence interval (CI): 1.09, 1.53; p = 0.004) for men and 1.42 (95% CI: 1.15, 1.75; p = 0.001) for women. The trend was similar for myocardial infarction, angina pectoris, and sudden cardiac death. The relation of triglycerides with coronary heart disease was not influenced materially by total cholesterol levels or, in a subsample analysis (51% of total sample), by high density lipoprotein cholesterol levels. Nonfasting serum triglycerides predict the incidence of coronary heart disease among Japanese men and women who possess low mean values of total cholesterol. Further adjustment for high density lipoprotein cholesterol suggests an independent role of triglycerides on the coronary heart disease risk.

309 citations

Journal ArticleDOI
TL;DR: The data obtained from the mouse study strongly suggest that hematopoietic stem cells residing in the donor liver are responsible for mixed chimerism and maintenance of tolerance after liver transplantation.
Abstract: Recently, cases have been reported in which a mixed chimeric state of blood cells is established after liver transplantation. Because the established chimerism may have aided in the induction of donor-specific tolerance, the mechanism responsible for this chimerism is of clinical importance. To establish this, we examined cells in adult mouse liver and identified the presence of c-kit+ Sca-1+ Lin(lo/-) cells. These cells were capable of forming in vivo as well as in vitro colonies. Furthermore, the cells could reconstitute bone marrow of lethally irradiated recipient mice for at least 12 months. These data obtained from the mouse study strongly suggest that hematopoietic stem cells residing in the donor liver are responsible for mixed chimerism and maintenance of tolerance after liver transplantation.

309 citations


Authors

Showing all 36572 results

NameH-indexPapersCitations
Aaron R. Folsom1811118134044
Kazuo Shinozaki178668128279
Hyun-Chul Kim1764076183227
Masayuki Yamamoto1711576123028
Hua Zhang1631503116769
Lewis L. Lanier15955486677
David Cella1561258106402
Takashi Taniguchi1522141110658
Yoshio Bando147123480883
Kazuhiko Hara1411956107697
Janet Rossant13841671913
Christoph Paus1371585100801
Kohei Miyazono13551568706
Craig Blocker134137994195
Fumihiko Ukegawa133149294465
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023104
2022323
20214,079
20203,887
20193,515
20183,388