University of Tsukuba

About: University of Tsukuba is a education organization based out in Tsukuba, Ibaraki, Japan. It is known for research contribution in the topics: Population & Gene. The organization has 36352 authors who have published 79483 publications receiving 1934752 citations. The organization is also known as: Tsukuba daigaku & Tsukuba University.

The Structure and Evolution of Early Cosmological H II Regions

Abstract: We study the formation and evolution of H II regions around the first stars formed at redshifts z = 10-30. We use a one-dimensional Lagrangian hydrodynamics code that self-consistently incorporates radiative transfer and nonequilibrium primordial gas chemistry. The star-forming region is defined as a spherical dense molecular gas cloud with a Population III star embedded at the center. We explore a large parameter space by considering, as plausible early star-forming sites, dark matter halos of mass Mhalo = 105-108 M☉, gas density profiles with a power-law index w = 1.5-2.25, and metal-free stars of mass Mstar = 25-500 M☉. The formation of the H II region is characterized by initial slow expansion of a weak D-type ionization front near the center, followed by rapid propagation of an R-type front throughout the outer gas envelope. We find that the transition between the two front types is indeed a critical condition for the complete ionization of halos of cosmological interest. In small-mass (106 M☉) halos, the transition takes place within a few 105 yr, yielding high escape fractions (>80%) of both ionizing and photodissociating photons. The gas is effectively evacuated by a supersonic shock, with the mean density within the halo decreasing to 1 cm-3 in a few million years. In larger mass (107 M☉) halos, the ionization front remains to be of D-type over the lifetime of the massive star, the H II region is confined well inside the virial radius, and the escape fractions are essentially zero. We derive an analytic formula that reproduces well the results of our simulations for the critical halo mass below which the gas is completely ionized. We discuss immediate implications of the present results for the star formation history and early reionization of the universe.

CpG Demethylation Enhances Alpha-Synuclein Expression and Affects the Pathogenesis of Parkinson's Disease

Abstract: Background: Alpha-synuclein (SNCA) gene expression is an important factor in the pathogenesis of Parkinson’s disease (PD). Gene multiplication can cause inherited PD, and promoter polymorphisms that increase SNCA expression are associated with sporadic PD. CpG methylation in the promoter region may also influence SNCA expression. Methodology/Principal Findings: By using cultured cells, we identified a region of the SNCA CpG island in which the methylation status altered along with increased SNCA expression. Postmortem brain analysis revealed regional non-specific methylation differences in this CpG region in the anterior cingulate and putamen among controls and PD; however, in the substantia nigra of PD, methylation was significantly decreased. Conclusions/Significance: This CpG region may function as an intronic regulatory element for SNCA gene. Our findings suggest that a novel epigenetic regulatory mechanism controlling SNCA expression influences PD pathogenesis.

Charged-particle multiplicity measurement in proton-proton collisions at $\sqrt{s}=7$ TeV with ALICE at LHC

Abstract: Charged-particle production was studied in proton-proton collisions collected at the LHC with the ALICE detector at centre-of-mass energies 0.9 TeV and 2.36 TeV in the pseudorapidity range vertical bar eta vertical bar < 1.4. In the central region (vertical bar eta vertical bar < 0.5), at 0.9 TeV, we measure charged-particle pseudo-rapidity density dN(ch)/d eta = 3.02 +/- 0.01(stat.)(-0.05)(+0.08)(syst.) for inelastic interactions, and dN(ch)/d eta = 3.58 +/- 0.01 (stat.)(-0.12)(+0.12)(syst.) for non-single-diffractive interactions. At 2.36 TeV, we find dN(ch)/d eta = 3.77 +/- 0.01(stat.)(-0.12)(+0.25)(syst.) for inelastic, and dN(ch)/d eta = 4.43 +/- 0.01(stat.)(-0.12)(+0.17)(syst.) for non-single-diffractive collisions. The relative increase in charged-particle multiplicity from the lower to higher energy is 24.7% +/- 0.5%(stat.)(-2.8)(+5.7)%(syst.) for inelastic and 23.7% +/- 0.5%(stat.)(-1.1)(+4.6)%(syst.) for non-single-diffractive interactions. This increase is consistent with that reported by the CMS collaboration for non-single-diffractive events and larger than that found by a number of commonly used models. The multiplicity distribution was measured in different pseudorapidity intervals and studied in terms of KNO variables at both energies. The results are compared to proton-antiproton data and to model predictions.

Optimisation of processing and properties of medical grade Nitinol wire

Abstract: Summary The purpose of this paper is to review the current processing and resultant properties of standard Nitinol wire for guide-wire applications. Optimised Ti-50.8at%Ni wire was manufactured according to industry standards by precise control of the composition, cold work and continuous strain-age annealing. Mechanical properties of this wire are reported from 100°C to 200°C to demonstrate the effects of test temperature. Within the ‘superelastic window’ the plateau stresses are linearly related to test temperature. Additional ageing treatments can be used as a tool to fine-tune transformation temperatures and mechanical properties. A review of the fatigue properties of thermomechanically-treated Nitinol wire shows that they are affected by test temperature, stress and strain.