University of Tsukuba

About: University of Tsukuba is a education organization based out in Tsukuba, Ibaraki, Japan. It is known for research contribution in the topics: Population & Gene. The organization has 36352 authors who have published 79483 publications receiving 1934752 citations. The organization is also known as: Tsukuba daigaku & Tsukuba University.

The cystine/cysteine cycle: a redox cycle regulating susceptibility versus resistance to cell death.

Abstract: The cystine/cysteine cycle: a redox cycle regulating susceptibility versus resistance to cell death

Renormalization of Spectral Line Shape and Dispersion below T c in Bi 2 Sr 2 CaCu 2 O 8 + δ

Abstract: Angle-resolved photoemission data in the superconducting state of ${\mathrm{Bi}}_{2}{\mathrm{Sr}}_{2}{\mathrm{CaCu}}_{2}{\mathrm{O}}_{8+\ensuremath{\delta}}$ show a kink in the dispersion along the zone diagonal, which is related via a Kramers-Kr\"onig analysis to a drop in the low energy scattering rate. As one moves towards $(\ensuremath{\pi},0)$, this kink evolves into a spectral dip. The occurrence of these anomalies in the dispersion and line shape throughout the zone indicates the presence of a new energy scale in the superconducting state.

Genetic Evidence that Small Maf Proteins Are Essential for the Activation of Antioxidant Response Element-Dependent Genes

Abstract: While small Maf proteins have been suggested to be essential for the Nrf2-mediated activation of antioxidant response element (ARE)-dependent genes, the extent of their requirement remains to be fully documented. To address this issue, we generated mafG::mafF double-mutant mice possessing MafK as the single available small Maf. Induction of the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene was significantly impaired in double-mutant mice treated with butylated hydroxyanisole, while other ARE-dependent genes were less affected. Similarly, in a keap1-null background, where many of the ARE-dependent genes are constitutively activated in an Nrf2-dependent manner, only a subset of ARE-dependent genes, including NQO1, were sensitive to a simultaneous deficiency in MafG and MafF. Examination of single and double small maf mutant cells revealed that MafK also contributes to the induction of ARE-dependent genes. To obtain decisive evidence, we established mafG::mafK::mafF triple-mutant fibroblasts that completely lack small Mafs and turned out to be highly susceptible to oxidative stress. We found that induction in response to diethyl maleate was abolished in a wider range of ARE-dependent genes in the triple-mutant cells. These data explicitly demonstrate that small Mafs play critical roles in the inducible expression of a significant portion of ARE-dependent genes.

Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells

Abstract: Notch and bone morphogenetic protein signaling pathways are important for cellular differentiation, and both have been implicated in vascular development In many cases the two pathways act similarly, but antagonistic effects have also been reported The underlying mechanisms and whether this is caused by an interplay between Notch and BMP signaling is unknown Here we report that expression of the Notch target gene, Herp2, is synergistically induced upon activation of Notch and BMP receptor signaling pathways in endothelial cells The synergy is mediated via RBP-Jκ/CBF-1 and GC-rich palindromic sites in the Herp2 promoter, as well as via interactions between the Notch intracellular domain and Smad that are stabilized by p/CAF Activated Notch and its downstream effector Herp2 were found to inhibit endothelial cell (EC) migration In contrast, BMP via upregulation of Id1 expression has been reported to promote EC migration Interestingly, Herp2 was found to antagonize BMP receptor/Id1-induced migration by inhibiting Id1 expression Our results support the notion that Herp2 functions as a critical switch downstream of Notch and BMP receptor signaling pathways in ECs

Quantifying excess deaths related to heatwaves under climate change scenarios: A multicountry time series modelling study

Abstract: BACKGROUND: Heatwaves are a critical public health problem. There will be an increase in the frequency and severity of heatwaves under changing climate. However, evidence about the impacts of clima ...