Institution
University of Tsukuba
Education•Tsukuba, Ibaraki, Japan•
About: University of Tsukuba is a education organization based out in Tsukuba, Ibaraki, Japan. It is known for research contribution in the topics: Population & Gene. The organization has 36352 authors who have published 79483 publications receiving 1934752 citations. The organization is also known as: Tsukuba daigaku & Tsukuba University.
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TL;DR: It is demonstrated that aryl hydrocarbon receptor (Ahr) has an important regulatory function in the commitment of Th17 cells and participates in Th17 cell differentiation through regulating Stat1 activation, a finding that constitutes additional mechanisms in the modulation of Th 17 cell development.
Abstract: IL-17-producing T helper cells (Th17) have been recently identified as a previously undescribed subset of helper T cells. Here, we demonstrate that aryl hydrocarbon receptor (Ahr) has an important regulatory function in the commitment of Th17 cells. Ahr was robustly induced under Th17-polarizing conditions. Ahr-deficient naive T cells showed a considerable loss in the ability to differentiate into Th17 cells when induced by TGF-β plus IL-6. We were able to demonstrate that Ahr interacts with Stat1 and Stat5, which negatively regulate Th17 development. Whereas Stat1 activation returned to its basal level in Ahr wild type naive T cells 24 h after stimulation with TGF-β plus IL-6, Stat1 remained activated in Ahr-deficient naive T cells after stimulation. These results indicate that Ahr participates in Th17 cell differentiation through regulating Stat1 activation, a finding that constitutes additional mechanisms in the modulation of Th17 cell development.
489 citations
TL;DR: This paper presents a short overview of the changes to the trigger and data acquisition systems during the first long shutdown of the LHC and shows the performance of the trigger system and its components based on the 2015 proton–proton collision data.
Abstract: During 2015 the ATLAS experiment recorded 3.8 fb(-1) of proton-proton collision data at a centre-of-mass energy of 13 TeV. The ATLAS trigger system is a crucial component of the experiment, respons ...
488 citations
TL;DR: In this article, an extensive search for Lyα emitters (LAEs) at z = 6.5 in the Subaru Deep Field was conducted, which revealed an apparent deficit at the bright end of ∼ 0.75 mag fainter L*, compared with that observed at z=5.7.
Abstract: We report an extensive search for Lyα emitters (LAEs) at z = 6.5 in the Subaru Deep Field. Subsequent spectroscopy with Subaru and Keck identified eight more LAEs, giving a total of 17 spectroscopically confirmed LAEs at z = 6.5. Based on this spectroscopic sample of 17, complemented by a photometric sample of 58 LAEs, we have derived a more accurate Lyα luminosity function of LAEs at z = 6.5, which reveals an apparent deficit at the bright end of ∼0.75 mag fainter L*, compared with that observed at z = 5.7. The difference in the LAE luminosity functions between z = 5.7 and 6.5 is significant at the 3 σ level, which is reduced to 2 σ when cosmic variance is taken into account. This result may imply that the reionization of the universe has not been completed at z = 6.5. We found that the spatial distribution of LAEs at z = 6.5 was homogeneous over the field. We discuss the implications of these results for the reionization of the universe. © 2006. The American Astronomical Society. All rights reserved.
487 citations
California Institute of Technology1, Agricultural Research Service2, University of Tsukuba3, University of Guelph4, University of Texas at Austin5, Princeton University6, Kuwait University7, University of Valencia8, University of Salamanca9, Agriculture and Agri-Food Canada10, University of Southern California11, European Academy of Bozen12, University of Grenoble13, Finnish Meteorological Institute14, National Autonomous University of Mexico15, University of Twente16, Comisión Nacional de Actividades Espaciales17, Vienna University of Technology18, Monash University19, Goddard Space Flight Center20, Massachusetts Institute of Technology21
TL;DR: The NASA Soil Moisture Active Passive (SMAP) mission has utilized a set of core validation sites as the primary methodology in assessing the soil moisture retrieval algorithm performance as mentioned in this paper.
487 citations
Scripps Institution of Oceanography1, University of Barcelona2, Hokkaido University3, United States Department of Energy4, California Institute of Technology5, École normale supérieure de Lyon6, University of Oxford7, University of Genoa8, Johns Hopkins University9, University of South Florida10, University of St Andrews11, Washington University in St. Louis12, University of Milan13, Discovery Institute14, Uppsala University15, Tokyo Metropolitan University16, Tokai University17, Okinawa Institute of Science and Technology18, University of California, Berkeley19, University of Tokyo20, Academy of Sciences of the Czech Republic21, IBM22, Max Planck Society23, University of Maryland, College Park24, University of Toronto25, University of Lausanne26, University of Victoria27, University of Tsukuba28, Kyoto University29, Osaka University30, Nagahama Institute of Bio-Science and Technology31, Sun Yat-sen University32, Juntendo University33, Children's Hospital Oakland Research Institute34
TL;DR: The results indicate that the amphioxus genome is elemental to an understanding of the biology and evolution of nonchordate deuterostomes, invertebrate chordates, and vertebrates.
Abstract: Cephalochordates, urochordates, and vertebrates evolved from a common ancestor over 520 million years ago To improve our understanding of chordate evolution and the origin of vertebrates, we intensively searched for particular genes, gene families, and conserved noncoding elements in the sequenced genome of the cephalochordate Branchiostoma floridae, commonly called amphioxus or lancelets Special attention was given to homeobox genes, opsin genes, genes involved in neural crest development, nuclear receptor genes, genes encoding components of the endocrine and immune systems, and conserved cis-regulatory enhancers The amphioxus genome contains a basic set of chordate genes involved in development and cell signaling, including a fifteenth Hox gene This set includes many genes that were co-opted in vertebrates for new roles in neural crest development and adaptive immunity However, where amphioxus has a single gene, vertebrates often have two, three, or four paralogs derived from two whole-genome duplication events In addition, several transcriptional enhancers are conserved between amphioxus and vertebrates--a very wide phylogenetic distance In contrast, urochordate genomes have lost many genes, including a diversity of homeobox families and genes involved in steroid hormone function The amphioxus genome also exhibits derived features, including duplications of opsins and genes proposed to function in innate immunity and endocrine systems Our results indicate that the amphioxus genome is elemental to an understanding of the biology and evolution of nonchordate deuterostomes, invertebrate chordates, and vertebrates
487 citations
Authors
Showing all 36572 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Aaron R. Folsom | 181 | 1118 | 134044 |
| Kazuo Shinozaki | 178 | 668 | 128279 |
| Hyun-Chul Kim | 176 | 4076 | 183227 |
| Masayuki Yamamoto | 171 | 1576 | 123028 |
| Hua Zhang | 163 | 1503 | 116769 |
| Lewis L. Lanier | 159 | 554 | 86677 |
| David Cella | 156 | 1258 | 106402 |
| Takashi Taniguchi | 152 | 2141 | 110658 |
| Yoshio Bando | 147 | 1234 | 80883 |
| Kazuhiko Hara | 141 | 1956 | 107697 |
| Janet Rossant | 138 | 416 | 71913 |
| Christoph Paus | 137 | 1585 | 100801 |
| Kohei Miyazono | 135 | 515 | 68706 |
| Craig Blocker | 134 | 1379 | 94195 |
| Fumihiko Ukegawa | 133 | 1492 | 94465 |