University of Tsukuba

About: University of Tsukuba is a education organization based out in Tsukuba, Ibaraki, Japan. It is known for research contribution in the topics: Population & Gene. The organization has 36352 authors who have published 79483 publications receiving 1934752 citations. The organization is also known as: Tsukuba daigaku & Tsukuba University.

An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene.

Abstract: A pseudogene is a gene copy that does not produce a functional, full-length protein. The human genome is estimated to contain up to 20,000 pseudogenes. Although much effort has been devoted to understanding the function of pseudogenes, their biological roles remain largely unknown. Here we report the role of an expressed pseudogene-regulation of messenger-RNA stability-in a transgene-insertion mouse mutant exhibiting polycystic kidneys and bone deformity. The transgene was integrated into the vicinity of the expressing pseudogene of Makorin1, called Makorin1-p1. This insertion reduced transcription of Makorin1-p1, resulting in destabilization of Makorin1 mRNA in trans by way of a cis-acting RNA decay element within the 5' region of Makorin1 that is homologous between Makorin1 and Makorin1-p1. Either Makorin1 or Makorin1-p1 transgenes could rescue these phenotypes. Our findings demonstrate a specific regulatory role of an expressed pseudogene, and point to the functional significance of non-coding RNAs.

Absence of suppression in particle production at large transverse momentum in √sNN = 200 GeV d + Au collisions

Abstract: Transverse momentum spectra of charged hadrons with p(T)<8 GeV/c and neutral pions with p(T)<10 GeV/c have been measured at midrapidity by the PHENIX experiment at BNL RHIC in d+Au collisions at sqrt[s(NN)]=200 GeV. The measured yields are compared to those in p+p collisions at the same sqrt[s(NN)] scaled up by the number of underlying nucleon-nucleon collisions in d+Au. The yield ratio does not show the suppression observed in central Au+Au collisions at RHIC. Instead, there is a small enhancement in the yield of high momentum particles.

Reversal of subjective temporal order due to arm crossing.

Abstract: How does the brain order successive events? Here we studied whether temporal order of two stimuli delivered in rapid succession, one to each hand, is determined before or after the stimuli are localized in space. When their arms were crossed, subjects could accurately report the temporal order, even when the interval between stimuli was as short as 70 ms. In most trials, subjects could also judge temporal order when their arms were crossed, but only if given adequate time (>1 s). At moderately short intervals (<300 ms), crossing the arms caused misreporting (that is, inverting) of the temporal order. Thus, at these intervals, the determining factor of temporal order was the spatial location of the hands. We suggest that it is not until the spatial locations of the hands are taken into account that the cutaneous signals from the respective hands are ordered in time.

Stellar Abundances for the Galactic Archeology (SAGA) Database — Compilation of the Characteristics of Known Extremely Metal-Poor Stars

Abstract: We describe the construction of a database of extremely metal-poor (EMP) stars in the Galaxy. Our database contains detailed elemental abundances, reported equivalent widths, atmospheric parameters, photometry, and binarity status, compiled from papers in the literature that report on studies of EMP halo stars with [Fe=H] �� 2.5. The compilation procedures for this database were designed to assemble data effectively from electronic tables available from online journals. We have also developed ad ata retrieval system that enables data searches by various criteria and illustrations to explore relationships between stored variables. Currently, our sample includes 1212 unique stars (many of which are studied by more than one group) with more than 15000 individual reported elemental abundances, covering relevant papers published by 2007 December. We discuss the global characteristics of the present database, as revealed by the EMP stars observed to date. For stars with [Fe=H] �� 2.5, the number of giants with reported abundances is larger than that of dwarfs by a factor of two. The fraction of carbon-rich stars (among the sample for which the carbon abundance is reported) amounts to � 30% for [Fe=H] �� 2.5. We find that known binaries exhibit different distributions of the orbital period, according to whether they are giants or dwarfs, and also as a function of the metallicity, although the total sample of such stars is still quite small.