Institution
University of Tübingen
Education•Tübingen, Germany•
About: University of Tübingen is a education organization based out in Tübingen, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 40555 authors who have published 84108 publications receiving 3015320 citations. The organization is also known as: Eberhard Karls University & Eberhard-Karls-Universität Tübingen.
Topics: Population, Transplantation, Immune system, Antigen, T cell
Papers published on a yearly basis
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National Institutes of Health1, University of Minnesota2, Max Planck Society3, University College London4, University of Washington5, French Institute of Health and Medical Research6, Paul Sabatier University7, Boston University8, University of Tübingen9, deCODE genetics10, Columbia University Medical Center11, Erasmus University Rotterdam12, Stanford University13, University of Thessaly14, Washington University in St. Louis15, Michael J. Fox Foundation16, German Center for Neurodegenerative Diseases17, New York State Department of Health18, University of Paris19, Centre national de la recherche scientifique20, University of Miami21, Indiana University22
TL;DR: This article conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls.
Abstract: We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide significant association; these and 6 additional previously reported loci were then tested in an independent set of 5,353 cases and 5,551 controls. Of the 32 tested SNPs, 24 replicated, including 6 newly identified loci. Conditional analyses within loci showed that four loci, including GBA, GAK-DGKQ, SNCA and the HLA region, contain a secondary independent risk variant. In total, we identified and replicated 28 independent risk variants for Parkinson's disease across 24 loci. Although the effect of each individual locus was small, risk profile analysis showed substantial cumulative risk in a comparison of the highest and lowest quintiles of genetic risk (odds ratio (OR) = 3.31, 95% confidence interval (CI) = 2.55–4.30; P = 2 × 10−16). We also show six risk loci associated with proximal gene expression or DNA methylation.
1,636 citations
National Institutes of Health1, Norwegian University of Science and Technology2, National Research Council3, University of São Paulo4, University of Tübingen5, University of Coimbra6, University of Paris7, French Institute of Health and Medical Research8, Chang Gung University9, Columbia University10, Mayo Clinic11, Tel Aviv University12, Technion – Israel Institute of Technology13, Rambam Health Care Campus14, Tel Aviv Sourasky Medical Center15, University of Rostock16, University Health Network17, National Taiwan Normal University18, University of Washington19, University of Tokyo20, Kobe University21, Magna Græcia University22, University of Toronto23, Singapore General Hospital24, Duke University25
TL;DR: Data collected demonstrate that there is a strong association between GBA mutations and Parkinson's disease, and those with a GBA mutation presented earlier with the disease, were more likely to have affected relatives, and were morelikely to have atypical clinical manifestations.
Abstract: Background Recent studies indicate an increased frequency of mutations in the gene encoding glucocerebrosidase (GBA), a deficiency of which causes Gaucher's disease, among patients with Parkinson's disease. We aimed to ascertain the frequency of GBA mutations in an ethnically diverse group of patients with Parkinson's disease. Methods Sixteen centers participated in our international, collaborative study: five from the Americas, six from Europe, two from Israel, and three from Asia. Each center genotyped a standard DNA panel to permit comparison of the genotyping results across centers. Genotypes and phenotypic data from a total of 5691 patients with Parkinson's disease (780 Ashkenazi Jews) and 4898 controls (387 Ashkenazi Jews) were analyzed, with multivariate logistic-regression models and the Mantel–Haenszel procedure used to estimate odds ratios across centers. Results All 16 centers could detect two GBA mutations, L444P and N370S. Among Ashkenazi Jewish subjects, either mutation was found in 15% of p...
1,629 citations
Memorial Sloan Kettering Cancer Center1, Netherlands Cancer Institute2, Cleveland Clinic3, Institut Gustave Roussy4, University of Texas MD Anderson Cancer Center5, University of Glasgow6, University of British Columbia7, University of Lyon8, Osaka University9, University of Ulsan10, Russian Railways11, McGill University12, Medical University of Vienna13, The Royal Marsden NHS Foundation Trust14, Georgetown University15, University of Tübingen16, Pfizer17, Harvard University18
TL;DR: Progression‐free survival was significantly longer with avelumab plus axitinib than with sunit inib among patients who received these agents as first‐line treatment for advanced renal‐cell carcinoma.
Abstract: Background In a single-group, phase 1b trial, avelumab plus axitinib resulted in objective responses in patients with advanced renal-cell carcinoma. This phase 3 trial involving previously...
1,597 citations
TL;DR: Recent results confirm the prominent role of astrocytes in glutathione metabolism and the defense against reactive oxygen species in brain and suggest an involvement of a compromised astroglial glutATHione system in the oxidative stress reported for neurological disorders.
1,582 citations
Book•
11 Nov 2002TL;DR: In this article, linear differential equations in Banach spaces are systematically treated with the help of Laplace transforms, and the central tool is an integrated version of Widder's theorem (characterizing Laplace transform of bounded functions).
Abstract: Linear differential equations in Banach spaces are systematically treated with the help of Laplace transforms. The central tool is an “integrated version” of Widder’s theorem (characterizing Laplace transforms of bounded functions). It holds in any Banach space (whereas the vector-valued version of Widder’s theorem itself holds if and only if the Banach space has the Radon-Nikodým property). The Hille-Yosida theorem and other generation theorems are immediate consequences. The method presented here can be applied to operators whose domains are not dense.
1,577 citations
Authors
Showing all 41039 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| John Q. Trojanowski | 226 | 1467 | 213948 |
| Lily Yeh Jan | 162 | 467 | 73655 |
| Monique M.B. Breteler | 159 | 546 | 93762 |
| Wolfgang Wagner | 156 | 2342 | 123391 |
| Thomas Meitinger | 155 | 716 | 108491 |
| Hermann Brenner | 151 | 1765 | 145655 |
| Amartya Sen | 149 | 689 | 141907 |
| Bernhard Schölkopf | 148 | 1092 | 149492 |
| Niels Birbaumer | 142 | 835 | 77853 |
| Detlef Weigel | 142 | 516 | 84670 |
| Peter Lang | 140 | 1136 | 98592 |
| Marco Colonna | 139 | 512 | 71166 |
| António Amorim | 136 | 1477 | 96519 |
| Alexis Brice | 135 | 870 | 83466 |
| Elias Campo | 135 | 761 | 85160 |