scispace - formally typeset
Search or ask a question
Institution

University of Tübingen

EducationTübingen, Germany
About: University of Tübingen is a education organization based out in Tübingen, Germany. It is known for research contribution in the topics: Population & Immune system. The organization has 40555 authors who have published 84108 publications receiving 3015320 citations. The organization is also known as: Eberhard Karls University & Eberhard-Karls-Universität Tübingen.


Papers
More filters
Journal ArticleDOI
23 Mar 2012-Immunity
TL;DR: It is found that all inflammasome activators also induced the secretion of IL-1α, leading to the cosecretion of both interleukin-1 cytokines and caspase-1 catalytic activity, defining a mode of action for caspasing-1.

434 citations

Journal ArticleDOI
15 Nov 2013-Science
TL;DR: The findings imply that domestic dogs are the culmination of a process that initiated with European hunter-gatherers and the canids with whom they interacted, and molecular dating suggests an onset of domestication there 18,800 to 32,100 years ago.
Abstract: The geographic and temporal origins of the domestic dog remain controversial, as genetic data suggest a domestication process in East Asia beginning 15,000 years ago, whereas the oldest doglike fossils are found in Europe and Siberia and date to >30,000 years ago. We analyzed the mitochondrial genomes of 18 prehistoric canids from Eurasia and the New World, along with a comprehensive panel of modern dogs and wolves. The mitochondrial genomes of all modern dogs are phylogenetically most closely related to either ancient or modern canids of Europe. Molecular dating suggests an onset of domestication there 18,800 to 32,100 years ago. These findings imply that domestic dogs are the culmination of a process that initiated with European hunter-gatherers and the canids with whom they interacted.

434 citations

Journal ArticleDOI
TL;DR: In this paper, a comprehensive evaluation of AI ethics guidelines is presented, highlighting overlaps but also omissions, and the extent to which the respective ethical principles and values are implemented in the practice of research, development and application of AI systems.
Abstract: Current advances in research, development and application of artificial intelligence (AI) systems have yielded a far-reaching discourse on AI ethics. In consequence, a number of ethics guidelines have been released in recent years. These guidelines comprise normative principles and recommendations aimed to harness the "disruptive" potentials of new AI technologies. Designed as a comprehensive evaluation, this paper analyzes and compares these guidelines highlighting overlaps but also omissions. As a result, I give a detailed overview of the field of AI ethics. Finally, I also examine to what extent the respective ethical principles and values are implemented in the practice of research, development and application of AI systems - and how the effectiveness in the demands of AI ethics can be improved.

434 citations

Journal ArticleDOI
TL;DR: In this paper, a high-resolution and physically based description of Antarctica bed topography using mass conservation is presented, revealing previously unknown basal features with major implications for glacier response to climate change.
Abstract: The Antarctic ice sheet has been losing mass over past decades through the accelerated flow of its glaciers, conditioned by ocean temperature and bed topography. Glaciers retreating along retrograde slopes (that is, the bed elevation drops in the inland direction) are potentially unstable, while subglacial ridges slow down the glacial retreat. Despite major advances in the mapping of subglacial bed topography, significant sectors of Antarctica remain poorly resolved and critical spatial details are missing. Here we present a novel, high-resolution and physically based description of Antarctic bed topography using mass conservation. Our results reveal previously unknown basal features with major implications for glacier response to climate change. For example, glaciers flowing across the Transantarctic Mountains are protected by broad, stabilizing ridges. Conversely, in the marine basin of Wilkes Land, East Antarctica, we find retrograde slopes along Ninnis and Denman glaciers, with stabilizing slopes beneath Moscow University, Totten and Lambert glacier system, despite corrections in bed elevation of up to 1 km for the latter. This transformative description of bed topography redefines the high- and lower-risk sectors for rapid sea level rise from Antarctica; it will also significantly impact model projections of sea level rise from Antarctica in the coming centuries.

433 citations

Journal ArticleDOI
01 Feb 1999-PALAIOS
TL;DR: In this article, the authors assume that otherwise soft sediments were sealed by firm and erosion-resistant biomats, which allowed "mat encrusters" (vendobionts; trilobozoan and other sponges) to get attached to sandy bottoms, and molluscan "mat scratchers" to scrape off an algal film, as if they were living on rocks.
Abstract: The strange biota of Neoproterozoic sea bottoms become more understandable if we assume that otherwise soft sediments were sealed by firm and erosion-resistant biomats. This allowed "mat encrusters" (vendobionts; trilobozoan and other sponges) to get attached to sandy bottoms, and molluscan "mat scratchers" to scrape off an algal film, as if they were living on rocks. Minute conical "mat stickers" (Cloudina) probably required a sticky substrate to become stabilized in upright position. Horizontal burrows are interpreted as the works of worm-like "undermat miners." Only the latter lifestyle appears to go back to the Mesoproterozoic; the others emerged in Vendian times and virtually disappeared when matgrounds became restricted to hostile environments in the wake of the Cambrian ecological revolution.

433 citations


Authors

Showing all 41039 results

NameH-indexPapersCitations
John Q. Trojanowski2261467213948
Lily Yeh Jan16246773655
Monique M.B. Breteler15954693762
Wolfgang Wagner1562342123391
Thomas Meitinger155716108491
Hermann Brenner1511765145655
Amartya Sen149689141907
Bernhard Schölkopf1481092149492
Niels Birbaumer14283577853
Detlef Weigel14251684670
Peter Lang140113698592
Marco Colonna13951271166
António Amorim136147796519
Alexis Brice13587083466
Elias Campo13576185160
Network Information
Related Institutions (5)
Heidelberg University
119.1K papers, 4.6M citations

98% related

Ludwig Maximilian University of Munich
161.5K papers, 5.7M citations

98% related

University of Zurich
124K papers, 5.3M citations

95% related

Technische Universität München
123.4K papers, 4M citations

95% related

Radboud University Nijmegen
83K papers, 3.2M citations

94% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023206
2022854
20214,701
20204,480
20194,045
20183,634