scispace - formally typeset
Search or ask a question
Institution

University of Tübingen

EducationTübingen, Germany
About: University of Tübingen is a education organization based out in Tübingen, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 40555 authors who have published 84108 publications receiving 3015320 citations. The organization is also known as: Eberhard Karls University & Eberhard-Karls-Universität Tübingen.


Papers
More filters
Journal ArticleDOI
TL;DR: Systemic SD-208 treatment initiated 3 days after the implantation of SMA-560 cells into the brains of syngeneic VM/Dk mice prolongs their median survival from 18.6 to 25.1 days, and animals responding toSD-208 showed an increased tumor infiltration by natural killer cells, CD8 T cells, and macrophages.
Abstract: The cytokine transforming growth factor (TGF)-beta, by virtue of its immunosuppressive and promigratory properties, has become a major target for the experimental treatment of human malignant gliomas. Here we characterize the effects of a novel TGF-beta receptor (TGF-betaR) I kinase inhibitor, SD-208, on the growth and immunogenicity of murine SMA-560 and human LN-308 glioma cells in vitro and the growth of and immune response to intracranial SMA-560 gliomas in syngeneic VM/Dk mice in vivo. SD-208 inhibits the growth inhibition of TGF-beta-sensitive CCL64 cells mediated by recombinant TGF-beta1 or TGF-beta2 or of TGF-beta-containing glioma cell supernatant at an EC(50) of 0.1 mumol/L. SD-208 blocks autocrine and paracrine TGF-beta signaling in glioma cells as detected by the phosphorylation of Smad2 or TGF-beta reporter assays and strongly inhibits constitutive and TGF-beta-evoked migration and invasion, but not viability or proliferation. Peripheral blood lymphocytes or purified T cells, cocultured with TGF-beta-releasing LN-308 glioma cells in the presence of SD-208, exhibit enhanced lytic activity against LN-308 targets. The release of interferon gamma and tumor necrosis factor alpha by these immune effector cells is enhanced by SD-208, whereas the release of interleukin 10 is reduced. SD-208 restores the lytic activity of polyclonal natural killer cells against glioma cells in the presence of recombinant TGF-beta or of TGF-beta-containing glioma cell supernatant. The oral bioavailability of SD-208 was verified by demonstrating the inhibition of TGF-beta-induced Smad phosphorylation in spleen and brain. Systemic SD-208 treatment initiated 3 days after the implantation of SMA-560 cells into the brains of syngeneic VM/Dk mice prolongs their median survival from 18.6 to 25.1 days. Histologic analysis revealed no difference in blood vessel formation, proliferation, or apoptosis. However, animals responding to SD-208 showed an increased tumor infiltration by natural killer cells, CD8 T cells, and macrophages. These data define TGF-beta receptor I kinase inhibitors such as SD-208 as promising novel agents for the treatment of human malignant glioma and other conditions associated with pathological TGF-beta activity.

405 citations

Journal ArticleDOI
TL;DR: It is postulate that a decrease in cellular hydration in liver and skeletal muscle triggers the protein catabolic states that accompany various diseases.

405 citations

Journal ArticleDOI
TL;DR: The INTEGRAL Science Data Centre (ISDC) as discussed by the authors provides the IntEGRAL data and means to analyse them to the scientific community and runs a gamma ray burst alert system that provides the position of gamma ray bursts on the sky within seconds to the community.
Abstract: The INTEGRAL Science Data Centre (ISDC) provides the INTEGRAL data and means to analyse them to the scientific community. The ISDC runs a gamma ray burst alert system that provides the position of gamma ray bursts on the sky within seconds to the community. It operates a quick-look analysis of the data within few hours that detects new and unexpected sources as well as it monitors the instruments. The ISDC processes the data through a standard analysis the results of which are provided to the observers together with their data.

405 citations

Journal ArticleDOI
TL;DR: Rotamere and Invertomere synthetisieren in organischen Molekulen geben sich durch die Temperaturabhangigkeit der NMR-Spektren zu erkennen as mentioned in this paper.
Abstract: Rotations- und Inversionsprozesse in organischen Molekulen geben sich durch die Temperaturabhangigkeit der NMR-Spektren zu erkennen. Das Studium der Substituenteneffekte auf die Aktivierungsbarrieren solcher Prozesse gestattet die Aufklarung von Reaktionsmechanismen, ferner lassen sich die Stabilitatsgrenzen von Isomeren ermitteln. Die Kenntnis der Stabilitatsgrenzen ist notwendig, um gezielt stabile Rotamere und Invertomere synthetisieren zu konnen.

405 citations

Journal ArticleDOI
TL;DR: Attentional influences have now been demonstrated throughout visual cortex, and their influence on the processing of visual information is profound, resulting in a neural representation of the visual world that is dominated by the behavioral relevance of the information, rather than designed to provide an accurate and complete description of it.

404 citations


Authors

Showing all 41039 results

NameH-indexPapersCitations
John Q. Trojanowski2261467213948
Lily Yeh Jan16246773655
Monique M.B. Breteler15954693762
Wolfgang Wagner1562342123391
Thomas Meitinger155716108491
Hermann Brenner1511765145655
Amartya Sen149689141907
Bernhard Schölkopf1481092149492
Niels Birbaumer14283577853
Detlef Weigel14251684670
Peter Lang140113698592
Marco Colonna13951271166
António Amorim136147796519
Alexis Brice13587083466
Elias Campo13576185160
Network Information
Related Institutions (5)
Heidelberg University
119.1K papers, 4.6M citations

98% related

Ludwig Maximilian University of Munich
161.5K papers, 5.7M citations

98% related

University of Zurich
124K papers, 5.3M citations

95% related

Technische Universität München
123.4K papers, 4M citations

95% related

Radboud University Nijmegen
83K papers, 3.2M citations

94% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023206
2022854
20214,700
20204,480
20194,045
20183,634