University of Tübingen

About: University of Tübingen is a education organization based out in Tübingen, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 40555 authors who have published 84108 publications receiving 3015320 citations. The organization is also known as: Eberhard Karls University & Eberhard-Karls-Universität Tübingen.

Genome-wide association studies identify four ER negative-specific breast cancer risk loci

Abstract: Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P = 2.1 × 10(-12) and LGR6, P = 1.4 × 10(-8)), 2p24.1 (P = 4.6 × 10(-8)) and 16q12.2 (FTO, P = 4.0 × 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.

Retinal bipolar cells: elementary building blocks of vision.

Abstract: Retinal bipolar cells are the first 'projection neurons' of the vertebrate visual system — all of the information needed for vision is relayed by this intraretinal connection. Each of the at least 13 distinct types of bipolar cells systematically transforms the photoreceptor input in a different way, thereby generating specific channels that encode stimulus properties, such as polarity, contrast, temporal profile and chromatic composition. As a result, bipolar cell output signals represent elementary 'building blocks' from which the microcircuits of the inner retina derive a feature-oriented description of the visual world.

Platelets secrete stromal cell–derived factor 1α and recruit bone marrow–derived progenitor cells to arterial thrombi in vivo

Abstract: The accumulation of smooth muscle and endothelial cells is essential for remodeling and repair of injured blood vessel walls. Bone marrow–derived progenitor cells have been implicated in vascular repair and remodeling; however, the mechanisms underlying their recruitment to the site of injury remain elusive. Here, using real-time in vivo fluorescence microscopy, we show that platelets provide the critical signal that recruits CD34+ bone marrow cells and c-Kit+ Sca-1+ Lin− bone marrow–derived progenitor cells to sites of vascular injury. Correspondingly, specific inhibition of platelet adhesion virtually abrogated the accumulation of both CD34+ and c-Kit+ Sca-1+ Lin− bone marrow–derived progenitor cells at sites of endothelial disruption. Binding of bone marrow cells to platelets involves both P-selectin and GPIIb integrin on platelets. Unexpectedly, we found that activated platelets secrete the chemokine SDF-1α, thereby supporting further primary adhesion and migration of progenitor cells. These findings establish the platelet as a major player in the initiation of vascular remodeling, a process of fundamental importance for vascular repair and pathological remodeling after vascular injury.

High rates of sea-level rise during the last interglacial period

Abstract: Sea level during the last interglacial stood at least 4 m higher than at present, with evidence of short-term fluctuations of up to 10 m. A new continuous sea level record from the Red Sea and coral ages suggest that during these fluctuations, sea level changes were on the order of 1.6 m per century. The last interglacial period, Marine Isotope Stage (MIS) 5e, was characterized by global mean surface temperatures that were at least 2 ∘C warmer than present1. Mean sea level stood 4–6 m higher than modern sea level2,3,4,5,6,7,8,9,10,11,12,13, with an important contribution from a reduction of the Greenland ice sheet1,14. Although some fossil reef data indicate sea-level fluctuations of up to 10 m around the mean3,4,5,6,7,8,9,11, so far it has not been possible to constrain the duration and rates of change of these shorter-term variations. Here, we use a combination of a continuous high-resolution sea-level record, based on the stable oxygen isotopes of planktonic foraminifera from the central Red Sea15,16,17,18, and age constraints from coral data to estimate rates of sea-level change during MIS-5e. We find average rates of sea-level rise of 1.6 m per century. As global mean temperatures during MIS-5e were comparable to projections for future climate change under the influence of anthropogenic greenhouse-gas emissions19,20, these observed rates of sea-level change inform the ongoing debate about high versus low rates of sea-level rise in the coming century21,22.