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Institution

University of Tübingen

EducationTübingen, Germany
About: University of Tübingen is a education organization based out in Tübingen, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 40555 authors who have published 84108 publications receiving 3015320 citations. The organization is also known as: Eberhard Karls University & Eberhard-Karls-Universität Tübingen.


Papers
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Journal ArticleDOI
TL;DR: Continuous lenalidomide-dexamethasone given until disease progression was associated with a significant improvement in progression-free survival, with an overall survival benefit at the interim analysis, among patients with newly diagnosed multiple myeloma who were ineligible for stem-cell transplantation.
Abstract: Background The combination melphalan–prednisone–thalidomide (MPT) is considered a standard therapy for patients with myeloma who are ineligible for stem-cell transplantation. However, emerging data on the use of lenalidomide and low-dose dexamethasone warrant a prospective comparison of the two approaches. Methods We randomly assigned 1623 patients to lenalidomide and dexamethasone in 28-day cycles until disease progression (535 patients), to the same combination for 72 weeks (18 cycles; 541 patients), or to MPT for 72 weeks (547 patients). The primary end point was progression-free survival with continuous lenalidomide–dexamethasone versus MPT. Results The median progression-free survival was 25.5 months with continuous lenalidomide–dexamethasone, 20.7 months with 18 cycles of lenalidomide–dexamethasone, and 21.2 months with MPT (hazard ratio for the risk of progression or death, 0.72 for continuous lenalidomide–dexamethasone vs. MPT and 0.70 for continuous lenalidomide–dexamethasone vs. 18 cycles of len...

651 citations

Journal ArticleDOI
31 May 2018
TL;DR: The success of MRSA is a consequence of the extensive arsenal of virulence factors produced by S. aureus combined with β-lactam resistance and, for most clones, resistance to other antibiotic classes as discussed by the authors.
Abstract: Since the 1960s, methicillin-resistant Staphylococcus aureus (MRSA) has emerged, disseminated globally and become a leading cause of bacterial infections in both health-care and community settings. However, there is marked geographical variation in MRSA burden owing to several factors, including differences in local infection control practices and pathogen-specific characteristics of the circulating clones. Different MRSA clones have resulted from the independent acquisition of staphylococcal cassette chromosome mec (SCCmec), which contains genes encoding proteins that render the bacterium resistant to most β-lactam antibiotics (such as methicillin), by several S. aureus clones. The success of MRSA is a consequence of the extensive arsenal of virulence factors produced by S. aureus combined with β-lactam resistance and, for most clones, resistance to other antibiotic classes. Clinical manifestations of MRSA range from asymptomatic colonization of the nasal mucosa to mild skin and soft tissue infections to fulminant invasive disease with high mortality. Although treatment options for MRSA are limited, several new antimicrobials are under development. An understanding of colonization dynamics, routes of transmission, risk factors for progression to infection and conditions that promote the emergence of resistance will enable optimization of strategies to effectively control MRSA. Vaccine candidates are also under development and could become an effective prevention measure.

650 citations

Journal ArticleDOI
TL;DR: An evaluation of stressors covering heat, cold, desiccation, oxygen depletion, pathogens and immunomodulatory factors combined with a variety of environmental pollutants revealed that synergistic interactions between the effects of various natural stressors and toxicants are not uncommon phenomena.

649 citations

Journal ArticleDOI
TL;DR: It is concluded that the lateral regions of the cerebellum are critical for the accurate functioning of an internal timing system.
Abstract: In a previous study (Ivry and Keele, in press), cerebellar patients were found to be impaired on both a motor and a perceptual task which required accurate timing. This report presents case study analyses of seven patients with focal lesions in the cerebellum. The lesions were predominantly in the lateral, hemispheric regions for four of the patients. For the remaining three patients, the lesions were centered near the medial zone of the cerebellum. The clinical evaluation of the patients also was in agreement with the different lesion foci: lateral lesions primarily impaired fine motor coordination, especially apparent in movements with the distal extremities and medial lesions primarily disturbed balance and gait. All of the patients were found to have increased variability in performing rhythmic tapping when tapping with an effector (finger or foot) ipsilateral to the lesion in comparison to their performance with a contralateral effector. Separable estimates of a central timekeeper component and an implementation component were derived from the total variability scores following a model developed by Wing and Kristofferson (1973). This analysis indicated that the poor performance of patients with lateral lesions can be attributed to a deficit in the central timing process. In contrast, patients with medial lesions are able to accurately determine when to make a response, but are unable to implement the response at the desired time. A similar dissociation between the lateral and medial regions has been observed on a time perception task in patients with cerebellar atrophy. It is concluded that the lateral regions of the cerebellum are critical for the accurate functioning of an internal timing system.

649 citations

Book ChapterDOI
10 Jul 2008
TL;DR: The effectiveness of the proposed method for learning and discrimination of malware behavior is demonstrated, especially in detecting novel instances of malware families previously not recognized by commercial anti-virus software.
Abstract: Malicious software in form of Internet worms, computer viruses, and Trojan horses poses a major threat to the security of networked systems. The diversity and amount of its variants severely undermine the effectiveness of classical signature-based detection. Yet variants of malware families share typical behavioral patternsreflecting its origin and purpose. We aim to exploit these shared patterns for classification of malware and propose a method for learning and discrimination of malware behavior. Our method proceeds in three stages: (a) behavior of collected malware is monitored in a sandbox environment, (b) based on a corpus of malware labeled by an anti-virus scanner a malware behavior classifieris trained using learning techniques and (c) discriminative features of the behavior models are ranked for explanation of classification decisions. Experiments with different heterogeneous test data collected over several months using honeypots demonstrate the effectiveness of our method, especially in detecting novelinstances of malware families previously not recognized by commercial anti-virus software.

648 citations


Authors

Showing all 41039 results

NameH-indexPapersCitations
John Q. Trojanowski2261467213948
Lily Yeh Jan16246773655
Monique M.B. Breteler15954693762
Wolfgang Wagner1562342123391
Thomas Meitinger155716108491
Hermann Brenner1511765145655
Amartya Sen149689141907
Bernhard Schölkopf1481092149492
Niels Birbaumer14283577853
Detlef Weigel14251684670
Peter Lang140113698592
Marco Colonna13951271166
António Amorim136147796519
Alexis Brice13587083466
Elias Campo13576185160
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023206
2022854
20214,700
20204,480
20194,045
20183,634