University of Turin

About: University of Turin is a education organization based out in Turin, Piemonte, Italy. It is known for research contribution in the topics: Population & Cancer. The organization has 29607 authors who have published 77952 publications receiving 2480900 citations. The organization is also known as: Universita degli Studi di Torino & Università degli Studi di Torino.

Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans.

Abstract: An endogenous ligand for the GH secretagogue-receptor (GHS-R) has been recently purified from rat and human stomach and named Ghrelin. It has been demonstrated that Ghrelin specifically stimulates GH secretion from rat pituitary cells in culture as well as in rats in vivo. In this preliminary study, in 4 normal adults [age (mean+/-SE): 28.6+/-3.5 yr; body mass index (BMI): 22.3+/-2.1 kg/m2] we administered 1.0 microg/kg Ghrelin or GHRH-29 to compare their GH-releasing activities in humans. In all subjects Ghrelin induced a prompt, marked and long-lasting increase in circulating GH levels (peak: 107.9+/-26.1 microg/l; AUC: 6503.1+/-1632.7 microg/l/h). The GH response to Ghrelin was clearly higher (p<0.05) than that after GHRH (peak: 22.3+/-4.5 microg/l; AUC: 1517.5+/-338.4 microg/l/h). In conclusion, this preliminary study shows that Ghrelin exerts a strong stimulatory effect on GH secretion in humans releasing more GH than GHRH.

Intrigue: Personalized recommendation of tourist attractions for desktop and hand held devices

Abstract: This paper presents INTRIGUE, a prototype tourist-information server that presents information about the area around Turin City, Italy, on desktop and hand held devices.This system recommends sightseeing destinations and itineraries by taking into account the preferences of heterogeneous tourist groups (such as families with children or the elderly) and explains the recommendations by addressing the group members' requirements. Moreover, the system provides an interactive agenda for scheduling the tour. The services offered by INTRIGUE rely on user modeling and adaptive hypermedia techniques; furthermore, XML-based technologies support the generation of the user interface and its adaptation to Web browsers and WAP minibrowsers.

Perinatal morbidity and mortality in early-onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE)

Abstract: Objectives Few data exist for counseling and perinatal management of women after an antenatal diagnosis of early-onset fetal growth restriction. Yet, the consequences of preterm delivery and its attendant morbidity for both mother and baby are far reaching. The objective of this study was to describe perinatal morbidity and mortality following early-onset fetal growth restriction based on time of antenatal diagnosis and delivery. Methods We report cohort outcomes for a prospective multicenter randomized management study of fetal growth restriction (Trial of Randomized Umbilical and Fetal Flow in Europe (TRUFFLE)) performed in 20 European perinatal centers between 2005 and 2010. Women with a singleton fetus at 26–32 weeks of gestation, with abdominal circumference 95th percentile, were recruited. The main outcome measure was a composite of fetal or neonatal death or severe morbidity: survival to discharge with severe brain injury, bronchopulmonary dysplasia, proven neonatal sepsis or necrotizing enterocolitis. Results Five-hundred and three of 542 eligible women formed the study group. Mean ± SD gestational age at diagnosis was 29 ± 1.6 weeks and mean ± SD estimated fetal weight was 881 ± 217 g; 12 (2.4%) babies died in utero. Gestational age at delivery was 30.7 ± 2.3 weeks, and birth weight was 1013 ± 321 g. Overall, 81% of deliveries were indicated by fetal condition and 97% were by Cesarean section. Of 491 liveborn babies, outcomes were available for 490 amongst whom there were 27 (5.5%) deaths and 118 (24%) babies suffered severe morbidity. These babies were smaller at birth (867 ± 251 g) and born earlier (29.6 ± 2.0 weeks). Death and severe morbidity were significantly related to gestational age, both at study entry and delivery and also with the presence of maternal hypertensive morbidity. The median time to delivery was 13 days for women without hypertension, 8 days for those with gestational hypertension, 4 days for pre-eclampsia and 3 days for HELLP syndrome. Conclusions Fetal outcome in this study was better than expected from contemporary reports: perinatal death was uncommon (8%) and 70% survived without severe neonatal morbidity. The intervals to delivery, death and severe morbidity were related to the presence and severity of maternal hypertensive conditions. Copyright © 2013 ISUOG. Published by John Wiley & Sons Ltd.

Distinctive thin‐bedded turbidite facies and related depositional environments in the Eocene Hecho Group (South‐central Pyrenees, Spain)

Abstract: The vertical and lateral stratigraphic relations of facies and facies associations, palaeocurrent directions, and geometry and internal organization of associated thick-bedded and coarse-grained bodies of sandstone provide the framework for distinguishing five thin-bedded turbidite facies in the Eocene Hecho Group, south-central Pyrenees, Spain. Each facies is characterized by a number of primary features which are palaeoenvironmental indicators by themselves. These features and their palaeoenvironmental significance are summarized below. 1 The impressive regularity and lateral persistence of bedding and depositional structures, combined with the association of thin hemipelagic intercalations are typical characteristics of the basin plain thin-bedded turbidites. Lateral variations in bed thickness, internal structures, grain size, sand: shale ratio, and amounts of hemipelagic intercalations are present in these sediments, but take place so gradually that they cannot generally be recognized at the scale of even very large exposures. The basin plain facies has a remarkable character of uniformity over great distances and considerable stratigraphic thicknesses. 2 Thickening-upward and/or symmetric cycles with individual thicknesses ranging from a few metres to a few tens of metres are typical of lobe-fringe thin-bedded turbidites. The sediments that comprise the cycles contain small but recognizable variations in bed thickness and sand: shale ratio. The diagnostic cyclic pattern can be detected in relatively small exposures. It should be noted that in absence of coarse-grained and thick-bedded sandstone of the depositional lobes the above cyclic pattern is diagnostic of fan-fringe areas. 3 An extremely irregular bedding pattern with lensing, wedding, and amalgamation of individual beds over very short distances, sharp rippled tops of many beds, and internal depositional structures indicative of mainly tractional processes without substantial fallout, are typical and exclusive characteristics of channelmouth thin-bedded turbidites. 4 Bundles of interbedded thin-bedded sandstone and mudstone as thick as a few metres that are separated in vertical sequences by mudstone units of roughly similar or greater thickness are typical of interchannel thin-bedded turbidites. The most diagnostic feature of this depositional environment is the presence of beds of sandstone filling broad shallow channels as probable crevasse-splays. 5 Thin, thoroughly rippled sandstone beds with marked divergence of the bedding attitude characterize the channel-margin facies. The divergence or expansion in thickness, is consistently toward the channel axis. Small and shallow channels filled with thin-bedded deposits, interpreted here as crevasses cut into channel edges or levees during period of severe overbanking are also characteristic.

Spectroscopic Characterization of Silicalite and Titanium-Silicalite

Abstract: Surface characterization of silicalite and titanium-silicalite is made by combined use of IR and UV-Vis reflectance spectroscopy. The nature of the IR modes and of the electronic transitions associated with framework titanium is discussed in detail. The perturbation caused by the adsorption of small polar molecules (H 2 O, NH 3 , CH 3 OH) on both the IR and UV-Vis spectra is discussed in terms of the formation of six-coordinated complexes by ligand insertion in the Ti(IV) coordination sphere. All the Ti(IV) is accessible to the interaction with the molecules.