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Institution

University of Turin

EducationTurin, Piemonte, Italy
About: University of Turin is a education organization based out in Turin, Piemonte, Italy. It is known for research contribution in the topics: Population & Cancer. The organization has 29607 authors who have published 77952 publications receiving 2480900 citations. The organization is also known as: Universita degli Studi di Torino & Università degli Studi di Torino.


Papers
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Journal ArticleDOI
TL;DR: Results of this consensus paper illustrate how theory and empirical research have converged to produce a composite picture of brain topography, physiology, and function that establishes the role of the cerebellum in many aspects of emotional processing.
Abstract: Over the past three decades, insights into the role of the cerebellum in emotional processing have substantially increased. Indeed, methodological refinements in cerebellar lesion studies and major technological advancements in the field of neuroscience are in particular responsible to an exponential growth of knowledge on the topic. It is timely to review the available data and to critically evaluate the current status of the role of the cerebellum in emotion and related domains. The main aim of this article is to present an overview of current facts and ongoing debates relating to clinical, neuroimaging, and neurophysiological findings on the role of the cerebellum in key aspects of emotion. Experts in the field of cerebellar research discuss the range of cerebellar contributions to emotion in nine topics. Topics include the role of the cerebellum in perception and recognition, forwarding and encoding of emotional information, and the experience and regulation of emotional states in relation to motor, cognitive, and social behaviors. In addition, perspectives including cerebellar involvement in emotional learning, pain, emotional aspects of speech, and neuropsychiatric aspects of the cerebellum in mood disorders are briefly discussed. Results of this consensus paper illustrate how theory and empirical research have converged to produce a composite picture of brain topography, physiology, and function that establishes the role of the cerebellum in many aspects of emotional processing.

356 citations

Journal ArticleDOI
TL;DR: Significant OS differences were observed in oligometastatic patients stratified according to type of metastatic presentation, and N status, and this risk classification scheme is proposed to be used in guiding selection of patients for clinical trials of ablative treatment.

356 citations

Journal ArticleDOI
11 Jul 2013-Nature
TL;DR: It is shown that formation of PI(3,4)P2 by class II phosphatidylinositol-3-kinase C2α (PI(3)K C2 α) spatiotemporally controls clathrin-mediated endocytosis and unravels a novel discrete function of PI (3, 4)P 2 in a central cell physiological process.
Abstract: Phosphoinositides serve crucial roles in cell physiology, ranging from cell signalling to membrane traffic. Among the seven eukaryotic phosphoinositides the best studied species is phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2), which is concentrated at the plasma membrane where, among other functions, it is required for the nucleation of endocytic clathrin-coated pits. No phosphatidylinositol other than PI(4,5)P2 has been implicated in clathrin-mediated endocytosis, whereas the subsequent endosomal stages of the endocytic pathway are dominated by phosphatidylinositol-3-phosphates(PI(3)P). How phosphatidylinositol conversion from PI(4,5)P2-positive endocytic intermediates to PI(3)P-containing endosomes is achieved is unclear. Here we show that formation of phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2) by class II phosphatidylinositol-3-kinase C2α (PI(3)K C2α) spatiotemporally controls clathrin-mediated endocytosis. Depletion of PI(3,4)P2 or PI(3)K C2α impairs the maturation of late-stage clathrin-coated pits before fission. Timed formation of PI(3,4)P2 by PI(3)K C2α is required for selective enrichment of the BAR domain protein SNX9 at late-stage endocytic intermediates. These findings provide a mechanistic framework for the role of PI(3,4)P2 in endocytosis and unravel a novel discrete function of PI(3,4)P2 in a central cell physiological process.

356 citations

Journal ArticleDOI
TL;DR: In this paper, the authors used Italian local government data to test for fiscal interaction arising from yardstick competition and found positive spatial auto-correlation in local tax rates of jurisdictions where the mayors run for re-election in uncertain contests, while interaction is absent where either mayors face a term limit or are backed by large majorities.

356 citations

Journal ArticleDOI
TL;DR: This study provides the first demonstration of specific GHS binding sites, other than GHS-R1, in breast cancer.
Abstract: The family of GH secretagogues (GHS) includes synthetic peptidyl (hexarelin) and nonpeptidyl (MK-0677) molecules possessing specific receptors in the pituitary and central nervous system as well as in peripheral tissues, including the heart and some endocrine organs. A gastric-derived peptide, named ghrelin, has recently been proposed as the natural ligand of the GHS receptors (GHS-Rs). The presence of specific GHS-Rs has now been investigated in nontumoral and neoplastic human breast tissue using a radioiodinated peptidyl GHS ([125I]-Tyr-Ala-hexarelin) as ligand. Specific binding sites for GHS were detected in membranes from several types of breast carcinomas, whereas a negligible binding was found in fibroadenomas and mammary parenchyma. The highest binding activity was found in well-differentiated (G1) invasive breast carcinomas and was progressively reduced in moderately (G2) to poorly (G3) differentiated tumors.[ 125I]-Tyr-Ala-hexarelin bound to tumor membranes was displaced by different unlabeled GH...

356 citations


Authors

Showing all 30045 results

NameH-indexPapersCitations
Michael Grätzel2481423303599
Lewis C. Cantley196748169037
Kenneth C. Anderson1781138126072
Elio Riboli1581136110499
Giacomo Bruno1581687124368
Silvia Franceschi1551340112504
Thomas E. Starzl150162591704
Paolo Boffetta148145593876
Marco Costa1461458105096
Pier Paolo Pandolfi14652988334
Andrew Ivanov142181297390
Chiara Mariotti141142698157
Tomas Ganz14148073316
Jean-Pierre Changeux13867276462
Dong-Chul Son138137098686
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023202
2022623
20215,733
20205,428
20194,544
20184,233