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Institution

University of Turku

EducationTurku, Finland
About: University of Turku is a education organization based out in Turku, Finland. It is known for research contribution in the topics: Population & Galaxy. The organization has 16296 authors who have published 45124 publications receiving 1505428 citations. The organization is also known as: Turun yliopisto & Åbo universitet.


Papers
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Journal ArticleDOI
TL;DR: The present results demonstrate that, following the primary insult, this damage evolves relatively rapidly within the first 4–12 h, and there is no evidence that additional necrotic neurons are recruited after longer recovery periods.
Abstract: In the course of a study on the pathogenesis of neuronal necrosis in severe hypoglycemia, the morphological characteristics reflecting reversible and irreversible neuronal lesions were examined as a function of time following normalization of blood glucose. To that end, closely spaced time intervals were studied in the rat cerebral cortex before, during, and up to 1 year after standardized pure hypoglycemic insults of 30 and 60 min of cerebral isoelectricity.

252 citations

Journal ArticleDOI
Valérie Turcot1, Yingchang Lu2, Yingchang Lu3, Heather M. Highland4  +486 moreInstitutions (129)
TL;DR: Exome-wide analysis identifies rare and low-frequency coding variants associated with body mass index that confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
Abstract: Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. The effect sizes of rare variants are ~10 times larger than those of common variants, with the largest effect observed in carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed ~7 kg more than non-carriers. Pathway analyses based on the variants associated with BMI confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.

252 citations

Journal ArticleDOI
TL;DR: Breast milk contains bifidobacteria and specific B ifidobacterium species that may promote healthy microbiota development that may predispose to disease later in life.
Abstract: Background: The establishment of gut microbiota is a stepwise process contributing to gut development and maturation of the immune system. Aberrant gut microbiota at an early age ma

252 citations

Journal ArticleDOI
TL;DR: Patterns in local species richness result from the action of two opposing forces: declining species pool and decreasing intensity of competition with altitude.
Abstract: Question: What is the relationship between species richness of vascular plants, bryophytes and macrolichens, and two important gradients in the alpine environment, altitude and local topography? Location: Northernmost Fennoscandia, 250-1525 m a.s.l. corresponding to the range between timberline and mountain top. Methods: The vegetation was sampled in six mountain areas. For each 25 vertical metres, the local topographic gradient from wind-blown ridge to snowbed was sampled in quadrats of 0.8 m · 0.8 m. Patterns in species richness were explored using Poisson regression (Generalized Linear Models). Functional groups of species, i.e. evergreen and deciduous dwarfshrubs, forbs, graminoids, mosses, hepatics and lichens were investigated separately. Results: Functional groups showed markedly different patterns with respect to both altitude and topography. Species richness of all vascular plants showed a unimodal relationship with altitude. The same was true for graminoids, forbs and lichens analysed separately, but forb richness peaked at much higher altitudes than total richness. The richness of dwarfshrubs decreased monotonically with altitude, whereas richness of mosses and liverworts showed an increasing trend. Significant interactions between altitude and local topography were present for several groups. The unimodal pattern for total plant species richness was interpreted in terms of local productivity, physical disturbance, trophic interactions, and in terms of species pool effects. Conclusions: Patterns in local species richness result from the action of two opposing forces: declining species pool and decreasing intensity of competition with altitude.

252 citations

Journal ArticleDOI
TL;DR: Findings illustrate that there were several factors influencing the young nurses' intentions and by identifying the factors responsible it could be possible to retain young nurses in the field.

251 citations


Authors

Showing all 16461 results

NameH-indexPapersCitations
Kari Alitalo174817114231
Mika Kivimäki1661515141468
Jaakko Kaprio1631532126320
Veikko Salomaa162843135046
Markus W. Büchler148154593574
Eugene C. Butcher14644672849
Steven Williams144137586712
Terho Lehtimäki1421304106981
Olli T. Raitakari1421232103487
Pim Cuijpers13698269370
Jeroen J. Bax132130674992
Sten Orrenius13044757445
Aarno Palotie12971189975
Stefan W. Hell12757765937
Carlos López-Otín12649483933
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023102
2022290
20212,673
20202,688
20192,407
20182,189