scispace - formally typeset
Search or ask a question
Institution

University of Turku

EducationTurku, Finland
About: University of Turku is a education organization based out in Turku, Finland. It is known for research contribution in the topics: Population & Galaxy. The organization has 16296 authors who have published 45124 publications receiving 1505428 citations. The organization is also known as: Turun yliopisto & Åbo universitet.


Papers
More filters
Journal ArticleDOI
TL;DR: In this article, a randomized, double-blind, placebo-controlled trial (ClinicalTrials.gov no. NCT00167700), 94 preterm infants (gestational age, ≥ 32+ 0 and ≤ 36+ 6 weeks; birth weight, >1500 g) were allocated to receive oral prebiotics (galacto-oligosaccharide and polydextrose mixture, 1:1), a probiotic (Lactobacillus rhamnosus GG, ATCC 53103), or placebo (microcrystalline cellulose
Abstract: Background Simple and safe strategies for the prevention of viral respiratory tract infections (RTIs) are needed. Objective We hypothesized that early prebiotic or probiotic supplementation would reduce the risk of virus-associated RTIs during the first year of life in a cohort of preterm infants. Methods In this randomized, double-blind, placebo-controlled trial (ClinicalTrials.gov no. NCT00167700), 94 preterm infants (gestational age, ≥32 + 0 and ≤36 + 6 weeks; birth weight, >1500 g) treated at Turku University Hospital, Turku, Finland, were allocated to receive oral prebiotics (galacto-oligosaccharide and polydextrose mixture, 1:1), a probiotic ( Lactobacillus rhamnosus GG, ATCC 53103), or placebo (microcrystalline cellulose) between days 3 and 60 of life. The primary outcome was the incidence of clinically defined virus-associated RTI episodes confirmed from nasal swabs by using nucleic acid testing. Secondary outcomes were the severity and duration of RTIs. Results A significantly lower incidence of RTIs was detected in infants receiving prebiotics (rate ratio [RR], 0.24; 95% CI, 0.12-0.49; P P = .022) compared with those receiving placebo. Also, the incidence of rhinovirus-induced episodes, which comprised 80% of all RTI episodes, was found to be significantly lower in the prebiotic (RR, 0.31; 95% CI, 0.14-0.66; P = .003) and probiotic (RR, 0.49; 95% CI, 0.24-1.00; P = .051) groups compared with the placebo group. No differences emerged among the study groups in rhinovirus RNA load during infections, duration of rhinovirus RNA shedding, duration or severity of rhinovirus infections, or occurrence of rhinovirus RNA in asymptomatic infants. Conclusions Gut microbiota modification with specific prebiotics and probiotics might offer a novel and cost-effective means to reduce the risk of rhinovirus infections.

220 citations

Journal ArticleDOI
TL;DR: The results show that TGF-β-elicited induction of MMP-13 expression by gingival fibroblasts is dependent on the activity of p38 MAPK and the presence of functional AP-1 dimers, and suggest a role for M MP-13 in rapid turnover of collagenous matrix during repair of gingivals wounds, which heal with minimal scarring.

219 citations

Journal Article
TL;DR: A peptide sequence with a high degree of specificity for PSA is identified and improved K(m)s and k(cat)s over previously used substrates are determined and it should be possible to use the HSSKLQ peptide as a carrier to target peptide-coupled prodrugs for selective activation within sites of PSA-secreting, metastatic prostate cancer cells and not within the blood or other nonprostatic normal tissues.
Abstract: Prostate-specific antigen (PSA) is a serine protease secreted by both normal prostate glandular cells and prostate cancer cells. The major proteolytic substrates for PSA are the gel-forming proteins in semen, semenogelin (Sg) I and II. On the basis of the PSA cleavage map for Sg I and II, a series of small peptides (i.e., < or = 7 amino acids) was synthesized and coupled at the COOH terminus to 7-amino-4-methyl coumarin. Using these fluorescently tagged substrates, K(m)s and k(cat)s were determined for PSA hydrolysis, and the substrates were also tested for activity against a panel of purified proteases. Previously, a variety of chymotrypsin substrates have been used to assay the enzymatic activity of PSA. The present studies have identified a peptide sequence with a high degree of specificity for PSA (ie., no detectable hydrolysis by chymotrypsin) and improved K(m)s and k(cat)s over previously used substrates. On the basis of these parameters, the best peptide substrate for PSA has the amino acid sequence HSSKLQ. Using PC-82 human prostate cancer xenografts and human prostate tissues, this PSA substrate was used to document that prostate cancer cells secrete enzymatically active PSA into the extracellular fluid but that once in the blood, PSA is not enzymatically active. On the basis of this information, it should be possible to use the HSSKLQ peptide as a carrier to target peptide-coupled prodrugs for selective activation within sites of PSA-secreting, metastatic prostate cancer cells and not within the blood or other nonprostatic normal tissues.

219 citations

Proceedings ArticleDOI
30 Jul 2009
TL;DR: This paper describes an effective way to compute any Boolean function with a small number of memristors, and the length of the corresponding computing sequence is considered.
Abstract: In this paper computation with memristors is studied in terms of how many memristors are needed to perform a given logic operation. It has been shown that memristors are naturally suited for performing implication logic (combination of implication and false operation) instead of Boolean logic. Also, it should be noted that a memristor can be used as both a logic gate and a latch (stateful logic). Being functionally complete, implication logic can be used to compute any Boolean function. However, by performing implication logic with stateful devices, storage of intermediate results requires additional memristors to keep data yet to be used from being written over. This paper describes an effective way to compute any Boolean function with a small number of memristors. Also, the length of the corresponding computing sequence is considered.

219 citations

Journal ArticleDOI
TL;DR: Two distinct and complementary signaling mechanisms mediating induction of M MP-1 and MMP-3 expression in dermal fibroblasts are identified: AP-1-dependent transcriptional activation via the ERK1/2 pathway and AP- 1-independent enhancement via p38α MAPK by mRNA stabilization.

219 citations


Authors

Showing all 16461 results

NameH-indexPapersCitations
Kari Alitalo174817114231
Mika Kivimäki1661515141468
Jaakko Kaprio1631532126320
Veikko Salomaa162843135046
Markus W. Büchler148154593574
Eugene C. Butcher14644672849
Steven Williams144137586712
Terho Lehtimäki1421304106981
Olli T. Raitakari1421232103487
Pim Cuijpers13698269370
Jeroen J. Bax132130674992
Sten Orrenius13044757445
Aarno Palotie12971189975
Stefan W. Hell12757765937
Carlos López-Otín12649483933
Network Information
Related Institutions (5)
University of Helsinki
113.1K papers, 4.6M citations

97% related

Lund University
124.6K papers, 5M citations

96% related

University of Copenhagen
149.7K papers, 5.9M citations

96% related

University of Amsterdam
140.8K papers, 5.9M citations

94% related

University of Manchester
168K papers, 6.4M citations

92% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023102
2022290
20212,673
20202,688
20192,407
20182,189