Institution
University of Turku
Education•Turku, Finland•
About: University of Turku is a education organization based out in Turku, Finland. It is known for research contribution in the topics: Population & Galaxy. The organization has 16296 authors who have published 45124 publications receiving 1505428 citations. The organization is also known as: Turun yliopisto & Åbo universitet.
Topics: Population, Galaxy, Poison control, Health care, Pregnancy
Papers published on a yearly basis
Papers
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TL;DR: Bond strengths of the luting cement tested on the dental ceramics following surface conditioning methods varied in accordance with the ceramic types, and hydrofluoric acid gel was effective mostly on the ceramic having glassy matrix in their structures.
618 citations
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TL;DR: The development of male germ cells in the seminiferous tubules of the testis involves three main phases: spermatogonial multiplication, meiosis, and spermiogenesis, which follows each other in regular fashion, giving rise to the wave of the seminifierous epithelium in most mammals.
Abstract: The development of male germ cells in the seminiferous tubules of the testis involves three main phases: spermatogonial multiplication, meiosis, and spermiogenesis. In the seminiferous epithelium, cells in these developmental phases are arranged in defined associations or stages. Along the seminiferous tubules, these stages follow each other in regular fashion, giving rise to the wave of the seminiferous epithelium in most mammals. The time interval between the appearance of the same cell association at a given point of the tubule is called the cycle of the seminiferous epithelium. The dependence of spermatogenesis on pituitary FSH and on androgens secreted by Leydig cells in the testicular interstitial tissue is well documented. The somatic components of the seminiferous epithelium, the Sertoli cells, are the primary targets of these hormones. However, the local mechanisms, i.e. how Sertoli cells interact with the germ cells at various stages of the seminiferous epithelial cycle, have remained poorly und...
608 citations
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TL;DR: It is very important to be able to enhance the stability of probiotic bacteria both in old and new applications in order to expand their new uses and also to guarantee minimum effective doses for particular products.
Abstract: Recent advances in probiotic research have finally confirmed the health benefits of some probiotic bacterial strains. In addition to their application to dairy products, probiotic bacteria are now being applied to new food products including fermented cereals, infant formulae and therapeutic foods. It is very important to be able to enhance the stability of probiotic bacteria both in old and new applications in order to expand their new uses and also to guarantee minimum effective doses for particular products.
606 citations
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TL;DR: It is shown that vimentin functionally contributes to EMT and is required for induction of Axl expression, and regulation of breast cancer cell migration in two- and three-dimensional matrices by vimentsin is Axl- dependent and that Axl functional contributes to lung extravasation of breast cancers cells in mice.
Abstract: Epithelial-to-mesenchymal transition (EMT) is a critical event in the progression toward cancer metastasis. The intermediate filament protein vimentin is an important marker of EMT and a requisite regulator of mesenchymal cell migration. However, it is not known how vimentin functionally contributes to cancer cell invasion. Here, we report that ectopic expression of oncogenic H-Ras-V12G and Slug induces vimentin expression and migration in pre-malignant breast epithelial cells. Conversely, vimentin expression is necessary for Slug- or H-Ras-V12G-induced EMT-associated migration. Furthermore, silencing of vimentin in breast epithelial cells results in specific changes in invasiveness-related gene expression including upregulation of RAB25 (small GTPase Rab25) and downregulation of AXL (receptor tyrosine kinase Axl), PLAU (plasminogen activator, urokinase) and ITGB4 (integrin β4-subunit). Importantly, gene expression profiling analyses reveal that vimentin expression correlates positively/negatively with these genes also in multiple breast cancer cell lines and breast cancer patient samples. Focusing on the tyrosine kinase Axl, we show that induction of vimentin by EMT is associated with upregulation of Axl expression and that Axl enhances the migratory activity of pre-malignant breast epithelial cells. Using null and knock-down cells and overexpression models, we also show that regulation of breast cancer cell migration in two- and three-dimensional matrices by vimentin is Axl- dependent and that Axl functionally contributes to lung extravasation of breast cancer cells in mice. In conclusion, our data show that vimentin functionally contributes to EMT and is required for induction of Axl expression. Moreover, these results provide a molecular explanation for vimentin-dependent cancer cell migration during EMT by identifying Axl as a key proximal component in this process.
603 citations
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TL;DR: In this paper, a novel concept in far-field fluorescence microscopy, ground state depletion (GSD), was introduced to overcome the classical diffraction resolution limit. But the concept was not applied to the localization of the outer region of the focus of a scanning fluorescence microscope.
Abstract: We introduce and study a novel concept in farfield fluorescence microscopy fundamentally overcoming the classical diffraction resolution limit. This is accomlished by reducing the spatial extent of the effective focus of a scanning fluorescence microscope. The reduction is achieved by depleting the ground-state energy of the molecules located in the outer region of the focus. Our theoretical study shows that ground-state-depletion fluorescence microscopy has the potential of increasing the resolution of far-field fluorescence microscopy by an order of magnitude which is equivalent to a lateral resolution of 15 NM.
600 citations
Authors
Showing all 16461 results
Name | H-index | Papers | Citations |
---|---|---|---|
Kari Alitalo | 174 | 817 | 114231 |
Mika Kivimäki | 166 | 1515 | 141468 |
Jaakko Kaprio | 163 | 1532 | 126320 |
Veikko Salomaa | 162 | 843 | 135046 |
Markus W. Büchler | 148 | 1545 | 93574 |
Eugene C. Butcher | 146 | 446 | 72849 |
Steven Williams | 144 | 1375 | 86712 |
Terho Lehtimäki | 142 | 1304 | 106981 |
Olli T. Raitakari | 142 | 1232 | 103487 |
Pim Cuijpers | 136 | 982 | 69370 |
Jeroen J. Bax | 132 | 1306 | 74992 |
Sten Orrenius | 130 | 447 | 57445 |
Aarno Palotie | 129 | 711 | 89975 |
Stefan W. Hell | 127 | 577 | 65937 |
Carlos López-Otín | 126 | 494 | 83933 |