Institution
University of Turku
Education•Turku, Finland•
About: University of Turku is a education organization based out in Turku, Finland. It is known for research contribution in the topics: Population & Galaxy. The organization has 16296 authors who have published 45124 publications receiving 1505428 citations. The organization is also known as: Turun yliopisto & Åbo universitet.
Topics: Population, Galaxy, Poison control, Health care, Pregnancy
Papers published on a yearly basis
Papers
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TL;DR: The results present rhinoviruses as important inducers of wheezing even in infancy and call for reevaluation of the role of rhinOViruses in the development of asthma.
Abstract: Background: Although known as common causes of upper respiratory infections, rhinoviruses, enteroviruses, and corona-viruses are poorly studied as inducers of wheezing in infants, and their possible role in the development of childhood asthma has not been investigated. Objective: The purposes of this study were to assess the occurrence of RV, enterovirus, and coronavirus infections in wheezing infants and to evaluate the association of these viral findings with early school-age asthma. Methods: In 1999, outcome in relation to asthma was studied in 82 of 100 initially recruited children who had been hospitalized for wheezing in infancy during the period 1992-1993. In 2000, etiologic viral studies regarding the index episode of wheezing were supplemented by rhinovirus, enterovirus, and coronavirus detection by RT-PCR from frozen nasopharyngeal aspirates in 81 of the children for whom adequate samples were available. Of these children, 66 had participated in the follow-up in 1999. Results: Rhinoviruses were identified in 27 (33%) of the 81 children, enteroviruses in 10 (12%), and coronaviruses in none. Rhinoviruses were present as single viral findings in 22 (81%) of the 27 rhinovirus-positive cases, and rhinovirus infections were associated with the presence of atopic dermatitis in infancy. Enteroviruses were commonly encountered in mixed infections and had no association with atopy. As single viral findings, rhinoviruses were associated with the development of asthma ( P = .047; odds ratio, 4.14; 95% CI, 1.02-16.77 versus rhinovirus-negative cases [by logistic regression adjusted for age, sex, and atopic dermatitis on entry)]. Conclusion: Our results present rhinoviruses as important inducers of wheezing even in infancy. The association with atopy and subsequent asthma calls for reevaluation of the role of rhinoviruses in the development of asthma. (J Allergy Clin Immunol 2003;111:66-71.)
406 citations
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TL;DR: The development and testing of the Nurse Competence Scale is described, an instrument with which the level of nurse competence can be assessed in different hospital work environments and the results provide strong evidence of the reliability and validity of the nurse competence Scale.
Abstract: Background. Self-assessment assists nurses to maintain and improve their practice by identifying their strengths and areas that may need to be further developed. Professional competence profiles encourage them to take an active part in the learning process of continuing education. Although competence recognition offers a way to motivate practising nurses to produce quality care, few measuring tools are available for this purpose.
Aim. This paper describes the development and testing of the Nurse Competence Scale, an instrument with which the level of nurse competence can be assessed in different hospital work environments.
Methods. The categories of the Nurse Competence Scale were derived from Benner's From Novice to Expert competency framework. A seven-step approach, including literature review and six expert groups, was used to identify and validate the indicators of nurse competence. After a pilot test, psychometric testing of the Nurse Competence Scale (content, construct and concurrent validity, and internal consistency) was undertaken with 498 nurses. The 73-item scale consists of seven categories, with responses on a visual analogy scale format. The frequency of using competencies was additionally tested with a four-point scale.
Results. Self-assessed overall scores indicated a high level of competence across categories. The Nurse Competence Scale data were normally distributed. The higher the frequency of using competencies, the higher was the self-assessed level of competence. Age and length of work experience had a positive but not very strong correlation with level of competence. According to the item analysis, the categories of the Nurse Competence Scale showed good internal consistency.
Conclusion. The results provide strong evidence of the reliability and validity of the Nurse Competence Scale.
406 citations
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TL;DR: A web application is implemented that uses key functions of R‐package SynergyFinder, and provides not only the flexibility of using multiple synergy scoring models, but also a user‐friendly interface for visualizing the drug combination landscapes in an interactive manner.
Abstract: Summary Rational design of drug combinations has become a promising strategy to tackle the drug sensitivity and resistance problem in cancer treatment. To systematically evaluate the pre-clinical significance of pairwise drug combinations, functional screening assays that probe combination effects in a dose-response matrix assay are commonly used. To facilitate the analysis of such drug combination experiments, we implemented a web application that uses key functions of R-package SynergyFinder, and provides not only the flexibility of using multiple synergy scoring models, but also a user-friendly interface for visualizing the drug combination landscapes in an interactive manner. Availability and implementation The SynergyFinder web application is freely accessible at https://synergyfinder.fimm.fi ; The R-package and its source-code are freely available at http://bioconductor.org/packages/release/bioc/html/synergyfinder.html . Contact jing.tang@helsinki.fi.
405 citations
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Ali Amin Al Olama1, Zsofia Kote-Jarai, Sonja I. Berndt2, David V. Conti3 +176 more•Institutions (53)
TL;DR: These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.
Abstract: Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of > 10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10(-8); 15 variants were identified among men of European ancestry, 7 were identified in multi-ancestry analyses and 1 was associated with early-onset prostate cancer. These 23 variants, in combination with known prostate cancer risk variants, explain 33% of the familial risk for this disease in European-ancestry populations. These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.
404 citations
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Erasmus University Rotterdam1, King's College London2, Johns Hopkins University3, National Institutes of Health4, National University of Singapore5, Hong Kong Polytechnic University6, University of Mainz7, QIMR Berghofer Medical Research Institute8, University of Melbourne9, University of Western Australia10, Singapore National Eye Center11, University of Bristol12, University of Tampere13, University of Toronto14, Capital Medical University15, Heidelberg University16, University of Jyväskylä17, University of Helsinki18, The Chinese University of Hong Kong19, Flinders University20, University of Wisconsin-Madison21, University of Tartu22, Agency for Science, Technology and Research23, Technische Universität München24, Duke University25, University of Turku26, National Research Council27, University College London28, Imperial College London29, University of Sydney30, Case Western Reserve University31, Royal Netherlands Academy of Arts and Sciences32, University of Edinburgh33, University of Split34, University of Zagreb35, Royal Edinburgh Hospital36, Moorfields Eye Hospital37, University of Pennsylvania38
TL;DR: The CREAM consortium conducted genome-wide meta-analyses, which identified 16 new loci for refractive error in individuals of European ancestry and 8 were shared with Asians, and identified 8 additional associated loci.
Abstract: Refractive error is the most common eye disorder worldwide and is a prominent cause of blindness Myopia affects over 30% of Western populations and up to 80% of Asians The CREAM consortium conducted genome-wide meta-analyses, including 37,382 individuals from 27 studies of European ancestry and 8,376 from 5 Asian cohorts We identified 16 new loci for refractive error in individuals of European ancestry, of which 8 were shared with Asians Combined analysis identified 8 additional associated loci The new loci include candidate genes with functions in neurotransmission (GRIA4), ion transport (KCNQ5), retinoic acid metabolism (RDH5), extracellular matrix remodeling (LAMA2 and BMP2) and eye development (SIX6 and PRSS56) We also confirmed previously reported associations with GJD2 and RASGRF1 Risk score analysis using associated SNPs showed a tenfold increased risk of myopia for individuals carrying the highest genetic load Our results, based on a large meta-analysis across independent multiancestry studies, considerably advance understanding of the mechanisms involved in refractive error and myopia
404 citations
Authors
Showing all 16461 results
Name | H-index | Papers | Citations |
---|---|---|---|
Kari Alitalo | 174 | 817 | 114231 |
Mika Kivimäki | 166 | 1515 | 141468 |
Jaakko Kaprio | 163 | 1532 | 126320 |
Veikko Salomaa | 162 | 843 | 135046 |
Markus W. Büchler | 148 | 1545 | 93574 |
Eugene C. Butcher | 146 | 446 | 72849 |
Steven Williams | 144 | 1375 | 86712 |
Terho Lehtimäki | 142 | 1304 | 106981 |
Olli T. Raitakari | 142 | 1232 | 103487 |
Pim Cuijpers | 136 | 982 | 69370 |
Jeroen J. Bax | 132 | 1306 | 74992 |
Sten Orrenius | 130 | 447 | 57445 |
Aarno Palotie | 129 | 711 | 89975 |
Stefan W. Hell | 127 | 577 | 65937 |
Carlos López-Otín | 126 | 494 | 83933 |