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Showing papers by "University of Twente published in 2009"


Journal ArticleDOI
TL;DR: In this article, the Nusselt number and the Reynolds number depend on the Rayleigh number Ra and the Prandtl number Pr, and the thicknesses of the thermal and the kinetic boundary layers scale with Ra and Pr.
Abstract: The progress in our understanding of several aspects of turbulent Rayleigh-Benard convection is reviewed. The focus is on the question of how the Nusselt number and the Reynolds number depend on the Rayleigh number Ra and the Prandtl number Pr, and on how the thicknesses of the thermal and the kinetic boundary layers scale with Ra and Pr. Non-Oberbeck-Boussinesq effects and the dynamics of the large scale convection roll are addressed as well. The review ends with a list of challenges for future research on the turbulent Rayleigh-Benard system.

1,372 citations


Journal ArticleDOI
D. Moody1
TL;DR: A set of principles for designing cognitively effective visual notations: ones that are optimized for human communication and problem solving are defined, which form a design theory, called the Physics of Notations, which focuses on the physical properties of notations rather than their logical properties.
Abstract: Visual notations form an integral part of the language of software engineering (SE). Yet historically, SE researchers and notation designers have ignored or undervalued issues of visual representation. In evaluating and comparing notations, details of visual syntax are rarely discussed. In designing notations, the majority of effort is spent on semantics, with graphical conventions largely an afterthought. Typically, no design rationale, scientific or otherwise, is provided for visual representation choices. While SE has developed mature methods for evaluating and designing semantics, it lacks equivalent methods for visual syntax. This paper defines a set of principles for designing cognitively effective visual notations: ones that are optimized for human communication and problem solving. Together these form a design theory, called the Physics of Notations as it focuses on the physical (perceptual) properties of notations rather than their logical (semantic) properties. The principles were synthesized from theory and empirical evidence from a wide range of fields and rest on an explicit theory of how visual notations communicate. They can be used to evaluate, compare, and improve existing visual notations as well as to construct new ones. The paper identifies serious design flaws in some of the leading SE notations, together with practical suggestions for improving them. It also showcases some examples of visual notation design excellence from SE and other fields.

1,200 citations


Journal ArticleDOI
01 Jan 2009-Brain
TL;DR: Alzheimer's disease patients display a loss of resting-state functional connectivity in lower alpha and beta bands even when a measure insensitive to volume conduction effects is used, and the modelling results suggest that highly connected neural network 'hubs' may be especially at risk in Alzheimer's disease.
Abstract: In this study we examined changes in the large-scale structure of resting-state brain networks in patients with Alzheimer's disease compared with non-demented controls, using concepts from graph theory. Magneto-encephalograms (MEG) were recorded in 18 Alzheimer's disease patients and 18 non-demented control subjects in a no-task, eyes-closed condition. For the main frequency bands, synchronization between all pairs of MEG channels was assessed using a phase lag index (PLI, a synchronization measure insensitive to volume conduction). PLI-weighted connectivity networks were calculated, and characterized by a mean clustering coefficient and path length. Alzheimer's disease patients showed a decrease of mean PLI in the lower alpha and beta band. In the lower alpha band, the clustering coefficient and path length were both decreased in Alzheimer's disease patients. Network changes in the lower alpha band were better explained by a 'Targeted Attack' model than by a 'Random Failure' model. Thus, Alzheimer's disease patients display a loss of resting-state functional connectivity in lower alpha and beta bands even when a measure insensitive to volume conduction effects is used. Moreover, the large-scale structure of lower alpha band functional networks in Alzheimer's disease is more random. The modelling results suggest that highly connected neural network 'hubs' may be especially at risk in Alzheimer's disease.

826 citations


Journal ArticleDOI
TL;DR: If a shift toward a greater contribution of bioenergy to energy supply takes place, the results of this study can be used to select the crops and countries that produce bioenergy in the most water-efficient way.
Abstract: All energy scenarios show a shift toward an increased percentage of renewable energy sources, including biomass. This study gives an overview of water footprints (WFs) of bioenergy from 12 crops that currently contribute the most to global agricultural production: barley, cassava, maize, potato, rapeseed, rice, rye, sorghum, soybean, sugar beet, sugar cane, and wheat. In addition, this study includes jatropha, a suitable energy crop. Since climate and production circumstances differ among regions, calculations have been performed by country. The WF of bioelectricity is smaller than that of biofuels because it is more efficient to use total biomass (e.g., for electricity or heat) than a fraction of the crop (its sugar, starch, or oil content) for biofuel. The WF of bioethanol appears to be smaller than that of biodiesel. For electricity, sugar beet, maize, and sugar cane are the most favorable crops [50 m3/gigajoule (GJ)]. Rapeseed and jatropha, typical energy crops, are disadvantageous (400 m3/GJ). For ethanol, sugar beet, and potato (60 and 100 m3/GJ) are the most advantageous, followed by sugar cane (110 m3/GJ); sorghum (400 m3/GJ) is the most unfavorable. For biodiesel, soybean and rapeseed show to be the most favorable WF (400 m3/GJ); jatropha has an adverse WF (600 m3/GJ). When expressed per L, the WF ranges from 1,400 to 20,000 L of water per L of biofuel. If a shift toward a greater contribution of bioenergy to energy supply takes place, the results of this study can be used to select the crops and countries that produce bioenergy in the most water-efficient way.

708 citations


Journal ArticleDOI
TL;DR: In vitro culturing of chondrocytes in CH-GA43/PA10 hydrogels revealed that after 2 weeks the cells were viable and retained their round shape, indicating thatCH-GA/PA hydrogel are promising as an artificial extracellular matrix for cartilage tissue engineering.

419 citations


Journal ArticleDOI
TL;DR: In this paper, the authors assess the water footprint of different primary energy carriers derived from biomass expressed as the amount of water consumed to produce a unit of energy (m3/GJ).

418 citations


Journal ArticleDOI
TL;DR: In this article, a set of experiments using different amounts of phase change materials (PCM) in self-compacting concrete mixes is presented, and it is shown that increasing PCM amounts lead to lower thermal conductivity and increased heat capacity, which significantly improve the thermal performance of concrete and therefore save energy.
Abstract: In order to come to a sustainable built environment the construction industry requires new energy saving concepts. One concept is to use Phase Change Materials (PCM), which have the ability to absorb and to release thermal energy at a specific temperature. This paper presents a set of experiments using different amounts of PCM in self-compacting concrete mixes. The study focuses on the direct mixing of micro-encapsulated PCM with concrete and its influence on the material properties. Therefore, the fresh concrete properties and the hardened properties are investigated. The hardened properties comprise strength tests and a thorough assessment of the thermal properties. It will be shown that increasing PCM amounts lead to lower thermal conductivity and increased heat capacity, which both significantly improve the thermal performance of concrete and therefore save energy. On the other hand a significant loss in strength and micro-structural analysis both indicate that a large part of the capsules is destroyed during the mixing process and releases its paraffin wax filling into the surrounding matrix. However, the compressive strength of our specimens still satisfies the demands of most structural applications.

407 citations


Journal ArticleDOI
TL;DR: In this article, a 2-armed poly(d,l-lactide) macromer with a molecular weight of 0.6 kg/mol or higher was used to construct photo-crosslinked networks.

386 citations


Journal ArticleDOI
TL;DR: The field of design theory and methodologies has a rich collection of research results that has been taught at educational institutions as well as applied to design practices as discussed by the authors, which has a gap between practical and educational usages.

377 citations


Journal ArticleDOI
TL;DR: One might consider sensations of fatigue and exhaustion during disease as a feed-forward mechanism to protect the subject from an excessive depletion of their energy stocks, to enhance the survival of the individual during disease.
Abstract: Physical exercise affects the equilibrium of the internal environment. During exercise the contracting muscles generate force or power and heat. So physical exercise is in fact a form of mechanical energy. This generated energy will deplete the energy stocks within the body. During exercise, metabolites and heat are generated, which affect the steady state of the internal environment. Depending on the form of exercise, sooner or later sensations of fatigue and exhaustion will occur. The physiological role of these sensations is protection of the exercising subject from the deleterious effects of exercise. Because of these sensations the subject will adapt his or her exercise strategy. The relationship between physical exercise and fatigue has been the scope of interest of many researchers for more than a century and is very complex. The exercise intensity, exercise endurance time and type of exercise are all variables that cause different effects within the body systems, which in turn create different types of sensation within the subject's mind during the exercise. Physical exercise affects the biochemical equilibrium within the exercising muscle cells. Among others, inorganic phosphate, protons, lactate and free Mg2+ accumulate within these cells. They directly affect the mechanical machinery of the muscle cell. Furthermore, they negatively affect the different muscle cell organelles that are involved in the transmission of neuronal signals. The muscle metabolites produced and the generated heat of muscle contraction are released into the internal environment, putting stress on its steady state. The tremendous increase in muscle metabolism compared with rest conditions induces an immense increase in muscle blood supply, causing an increase in the blood circulatory system and gas exchange. Nutrients have to be supplied to the exercising muscle, emptying the energy stocks elsewhere in body. Furthermore, the contracting muscle fibres release cytokines, which in their turn create many effects in other organs, including the brain. All these different mechanisms sooner or later create sensations of fatigue and exhaustion in the mind of the exercising subject. The final effect is a reduction or complete cessation of the exercise. Many diseases speed up the depletion of the energy stocks within the body. So diseases amplify the effect of energy stock depletion that accompanies exercise. In addition, many diseases produce a change of mind-set before exercise. These changes of mind-set can create sensations of fatigue and exercise-avoiding behaviour at the onset of an exercise. One might consider these sensations during disease as a feed-forward mechanism to protect the subject from an excessive depletion of their energy stocks, to enhance the survival of the individual during disease.

357 citations


Journal ArticleDOI
TL;DR: It is indicated that participation in online support groups can make a valuable contribution to the empowerment of patients.

Journal ArticleDOI
TL;DR: The contribution of laser speckle contrast techniques to the field of perfusion visualization is presented and the development of the techniques are discussed.
Abstract: When a diffuse object is illuminated with coherent laser light, the backscattered light will form an interference pattern on the detector. This pattern of bright and dark areas is called a speckle pattern. When there is movement in the object, the speckle pattern will change over time. Laser speckle contrast techniques use this change in speckle pattern to visualize tissue perfusion. We present and review the contribution of laser speckle contrast techniques to the field of perfusion visualization and discuss the development of the techniques.

Journal ArticleDOI
TL;DR: Deterministic ferroelastic switching in rhombohedral BiFeO(3) is demonstrated by domain nucleation with a scanning probe and the controlled creation of a ferrotoroidal order parameter is demonstrated.
Abstract: Multiferroic materials showing coupled electric, magnetic and elastic orderings provide a platform to explore complexity and new paradigms for memory and logic devices. Until now, the deterministic control of non-ferroelectric order parameters in multiferroics has been elusive. Here, we demonstrate deterministic ferroelastic switching in rhombohedral BiFeO3 by domain nucleation with a scanning probe. We are able to select among final states that have the same electrostatic energy, but differ dramatically in elastic or magnetic order, by applying voltage to the probe while it is in lateral motion. We also demonstrate the controlled creation of a ferrotoroidal order parameter. The ability to control local elastic, magnetic and torroidal order parameters with an electric field will make it possible to probe local strain and magnetic ordering, and engineer various magnetoelectric, domain-wall-based and strain-coupled devices.

Journal ArticleDOI
TL;DR: A software-defined radio (SDR) receiver with improved robustness to out-of-band interference (OBI) is presented and an accurate multiphase clock generator is presented for a mismatch-robust HR.
Abstract: A software-defined radio (SDR) receiver with improved robustness to out-of-band interference (OBI) is presented. Two main challenges are identified for an OBI-robust SDR receiver: out-of-band nonlinearity and harmonic mixing. Voltage gain at RF is avoided, and instead realized at baseband in combination with low-pass filtering to mitigate blockers and improve out-of-band IIP3. Two alternative ?iterative? harmonic-rejection (HR) techniques are presented to achieve high HR robust to mismatch: a) an analog two-stage polyphase HR concept, which enhances the HR to more than 60 dB; b) a digital adaptive interference cancelling (AIC) technique, which can suppress one dominating harmonic by at least 80 dB. An accurate multiphase clock generator is presented for a mismatch-robust HR. A proof-of-concept receiver is implemented in 65 nm CMOS. Measurements show 34 dB gain, 4 dB NF, and + 3.5 dBm in-band IIP3 while the out-of-band IIP3 is +16 dBm without fine tuning. The measured RF bandwidth is up to 6 GHz and the 8-phase LO works up to 0.9 GHz (master clock up to 7.2 GHz). At 0.8 GHz LO, the analog two-stage polyphase HR achieves a second to sixth order HR > 60 dB over 40 chips, while the digital AIC technique achieves HR > 80 dB for the dominating harmonic. The total power consumption is 50 mA from a 1.2 V supply.

Journal ArticleDOI
TL;DR: Improvement of hydrodynamics and reduction of the spacer shadow effect directly result in a significant increase in power output of the RED process, and values almost double the values currently obtained can be realized, which brings RED close to economical viability.
Abstract: Reverse electrodialysis (RED) is a nonpolluting sustainable technology that converts the free energy of mixing of two solutions with different salinity directly into electrical energy. Although the theoretical potential is high, the practical power output obtained is limited yet due to concentration polarization phenomena and spacer shadow effects. In this work we combine theoretical calculations with direct current and alternating current experimental stack characterization methods to quantify the contribution of concentration polarization phenomena, spacer shadow effects and stack resistance in RED under different hydrodynamic conditions in a temperature range from 10 to 40 °C to show the practical potential of RED. Concentration polarization phenomena play an important role and their influence can be minimized by optimal stack hydrodynamics. Improved spacer designs and new spacer concepts offer extensive room to reduce the spacer shadow effect and to further increase the practical power output. Improvement of hydrodynamics and reduction of the spacer shadow effect directly result in a significant increase in power output of the RED process, and values almost double the values currently obtained can be realized, which brings RED close to economical viability.

Proceedings ArticleDOI
19 Jul 2009
TL;DR: Generic methods for placing photos uploaded to Flickr on the World map use the textual annotations provided by the users to predict the single most probable location where the image was taken to achieve at least twice the precision of the state-of-the-art reported in the literature.
Abstract: In this paper we investigate generic methods for placing photos uploaded to Flickr on the World map. As primary input for our methods we use the textual annotations provided by the users to predict the single most probable location where the image was taken. Central to our approach is a language model based entirely on the annotations provided by users. We define extensions to improve over the language model using tag-based smoothing and cell-based smoothing, and leveraging spatial ambiguity. Further we demonstrate how to incorporate GeoNames\footnote{http://www.geonames.org visited May 2009}, a large external database of locations. For varying levels of granularity, we are able to place images on a map with at least twice the precision of the state-of-the-art reported in the literature.

Journal ArticleDOI
TL;DR: Results did reveal that age had a negative effect on selecting irrelevant search results, and lower levels of education and aging seem to contribute to the amount of experienced operational and formal skill related problems.

Journal ArticleDOI
TL;DR: In this paper, the degradation process of nitric oxide (NO) under laboratory conditions is studied using a test setup for measuring the performance of photocatalytic active concrete products.

Journal ArticleDOI
TL;DR: This paper presents a 2.2-GHz low jitter sub-sampling based PLL that uses a phase-detector/charge-pump (PD/CP) that sub-samples the VCO output with the reference clock that guarantees correct frequency locking without degenerating jitter performance when in lock.
Abstract: This paper presents a 2.2-GHz low jitter sub-sampling based PLL. It uses a phase-detector/charge-pump (PD/CP) that sub-samples the VCO output with the reference clock. In contrast to what happens in a classical PLL, the PD/CP noise is not multiplied by N 2 in this sub-sampling PLL, resulting in a low noise contribution from the PD/CP. Moreover, no frequency divider is needed in the locked state and hence divider noise and power can be eliminated. An added frequency locked loop guarantees correct frequency locking without degenerating jitter performance when in lock. The PLL is implemented in a standard 0.18- ?m CMOS process. It consumes 4.2 mA from a 1.8 V supply and occupies an active area of 0.4 × 0.45 mm2. With a frequency division ratio of 40, the in-band phase noise at 200 kHz offset is measured to be -126 dBc/Hz. The rms PLL output jitter integrated from 10 kHz to 40 MHz is 0.15 ps.

Proceedings ArticleDOI
07 May 2009
TL;DR: This paper analyzes the mutual nesting of practical problems and knowledge problems, derives some methodological guidelines from this for design science researchers, and gives an example of a design science project following this problem nesting.
Abstract: Design science emphasizes the connection between knowledge and practice by showing that we can produce scientific knowledge by designing useful things. However, without further guidelines, aspiring design science researchers tend to identify practical problems with knowledge questions, which may lead to methodologically unsound research designs. To solve a practical problem, the real world is changed to suit human purposes, but to solve a knowledge problem, we acquire knowledge about the world without necessarily changing it. In design science, these two kinds of problems are mutually nested, but this nesting should not blind us for the fact that their problem-solving and solution justification methods are different. This paper analyzes the mutual nesting of practical problems and knowledge problems, derives some methodological guidelines from this for design science researchers, and gives an example of a design science project following this problem nesting.

Journal ArticleDOI
TL;DR: In this paper, the authors view e-HRM as an umbrella term covering the integration of HRM and IT, aimed at creating value for targeted employees and managers, and discuss key issues and new challenges in eHRM research.
Abstract: This introduction has become a reflection on a two-year debate during the e-HRM and HRIS conferences and therefore echoes the latest discussions about e-HRM research and its role within organizations from both HR- and IT-centred studies. We view e-HRM as an umbrella term covering the integration of HRM and IT, aimed at creating value for targeted employees and managers. This editorial discusses key issues and new challenges in e-HRM research.

Journal ArticleDOI
TL;DR: In this article, an intensive study has been performed to understand and tune deep reactive ion etch (DRIE) processes for optimum results with respect to the silicon etch rate, etch profile and mask etch selectivity.
Abstract: An intensive study has been performed to understand and tune deep reactive ion etch (DRIE) processes for optimum results with respect to the silicon etch rate, etch profile and mask etch selectivity (in order of priority) using state-of-the-art dual power source DRIE equipment. The research compares pulsed-mode DRIE processes (e.g. Bosch technique) and mixed-mode DRIE processes (e.g. cryostat technique). In both techniques, an inhibitor is added to fluorine-based plasma to achieve directional etching, which is formed out of an oxide-forming (O2) or a fluorocarbon (FC) gas (C4F8 or CHF3). The inhibitor can be introduced together with the etch gas, which is named a mixed-mode DRIE process, or the inhibitor can be added in a time-multiplexed manner, which will be termed a pulsed-mode DRIE process. Next, the most convenient mode of operation found in this study is highlighted including some remarks to ensure proper etching (i.e. step synchronization in pulsed-mode operation and heat control of the wafer). First of all, for the fabrication ...... Enjoy reading . Henri Jansen 18 June 2008

Book ChapterDOI
22 Jun 2009
TL;DR: It is hoped that this survey will make clear that the authors need to design different games than they used to, but that such games can nevertheless be interesting and exciting.
Abstract: In recent years we have seen a rising interest in brain-computer interfacing for human-computer interaction and potential game applications. Until now, however, we have almost only seen attempts where BCI is used to measure the affective state of the user or in neurofeeedback games. There have hardly been any attempts to design BCI games where BCI is considered to be one of the possible input modalities that can be used to control the game. One reason may be that research still follows the paradigms of the traditional, medically oriented, BCI approaches. In this paper we discuss current BCI research from the viewpoint of games and game design. It is hoped that this survey will make clear that we need to design different games than we used to, but that such games can nevertheless be interesting and exciting.

Journal ArticleDOI
20 Apr 2009-Langmuir
TL;DR: In this article, the authors investigate drop impact dynamics on different superhydrophobic surfaces, consisting of regular polymeric micropatterns and rough carbon nanofibers, with similar static contact angles.
Abstract: We experimentally investigate drop impact dynamics onto different superhydrophobic surfaces, consisting of regular polymeric micropatterns and rough carbon nanofibers, with similar static contact angles. The main control parameters are the Weber number We and the roughness of the surface. At small We, i.e., small impact velocity, the impact evolutions are similar for both types of substrates, exhibiting Fakir state, complete bouncing, partial rebouncing, trapping of an air bubble, jetting, and sticky vibrating water balls. At large We, splashing impacts emerge forming several satellite droplets, which are more pronounced for the multiscale rough carbon nanofiber jungles. The results imply that the multiscale surface roughness at nanoscale plays a minor role in the impact events for small We 120 but an important one for large We 120. Finally, we find the effect of ambient air pressure to be negligible in the explored parameter regime We 150.

Journal ArticleDOI
TL;DR: This paper investigated the similarity of the factor structure for self-reported versus supervisor-rated employability for two age groups of workers, and then validated a career success enhancing model of employability across the two groups.

Journal ArticleDOI
TL;DR: Laser Doppler flowmetry is a non-invasive method of measuring microcirculatory blood flow in tissue and the research done so far to overcome limitations is critically assessed.
Abstract: Laser Doppler flowmetry is a non-invasive method of measuring microcirculatory blood flow in tissue. In this review the technique is discussed in detail. The theoretical and experimental developments to improve the technique are reviewed. The limitations of the method are elaborated upon, and the research done so far to overcome these limitations is critically assessed.

Journal ArticleDOI
TL;DR: The outcome of the race for the surface between bacteria and tissue cells is dependent on the number of bacteria present prior to cell seeding, and the number and spread area per cell decreased with increasing density of adhering staphylococci.

Journal ArticleDOI
TL;DR: In this paper, it was shown that TFM can accurately predict the hydrodynamics of Geldart A particles inside bubbling gas-fluidized beds, without any artificial modifications, provided that a sufficiently fine grid size and small time step is used.

Journal ArticleDOI
TL;DR: In this article, the authors derived a Kugel-Khomskii spin-orbital Hamiltonian for the active t2g orbitals of the parent compounds of recently discovered iron-based superconductors.
Abstract: We develop an understanding of the anomalous metal state of the parent compounds of recently discovered iron-based superconductors starting from a strong-coupling viewpoint, including orbital degrees of freedom. On the basis of an intermediate-spin (S=1) state for the Fe2+ ions, we derive a Kugel-Khomskii spin-orbital Hamiltonian for the active t2g orbitals. It turns out to be a highly complex model with frustrated spin and orbital interactions. We compute its classical phase diagrams and provide an understanding for the stability of the various phases by investigating its spin-only and orbital-only limits. The experimentally observed spin-stripe state is found to be stable over a wide regime of physical parameters and can be accompanied by three different types of orbital orders. Of these the orbital-ferro and orbital-stripe orders are particularly interesting since they break the in-plane lattice symmetry—a robust feature of the undoped compounds. We compute the magnetic excitation spectra for the effective spin Hamiltonian, observing a strong reduction in the ordered moment, and point out that the proposed orbital ordering pattern can be measured in resonant x-ray diffraction.

Journal ArticleDOI
TL;DR: It is shown that A‐type lamins have a key role in the maintenance of telomere structure, length and function, and in the stabilization of 53BP1, a component of the DNA damage response (DDR) pathway.
Abstract: A-type lamins are intermediate filament proteins that provide a scaffold for protein complexes regulating nuclear structure and function. Mutations in the LMNA gene are linked to a variety of degenerative disorders termed laminopathies, whereas changes in the expression of lamins are associated with tumourigenesis. The molecular pathways affected by alterations of A-type lamins and how they contribute to disease are poorly understood. Here, we show that A-type lamins have a key role in the maintenance of telomere structure, length and function, and in the stabilization of 53BP1, a component of the DNA damage response (DDR) pathway. Loss of A-type lamins alters the nuclear distribution of telomeres and results in telomere shortening, defects in telomeric heterochromatin, and increased genomic instability. In addition, A-type lamins are necessary for the processing of dysfunctional telomeres by non-homologous end joining, putatively through stabilization of 53BP1. This study shows new functions for A-type lamins in the maintenance of genomic integrity, and suggests that alterations of telomere biology and defects in DDR contribute to the pathogenesis of lamin-related diseases.