Institution
University of Udine
Education•Udine, Italy•
About: University of Udine is a education organization based out in Udine, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 6745 authors who have published 20530 publications receiving 669088 citations. The organization is also known as: Università degli Studi di Udine & Universita degli Studi di Udine.
Topics: Population, Large Hadron Collider, Transplantation, Lepton, Higgs boson
Papers published on a yearly basis
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TL;DR: All patients meeting the criteria for idiopathic or primary HES should be screened for the FIP1L1-PDGFRα rearrangement, and chronic imatinib treatment at doses as low as 100 mg daily ensures complete and durable responses.
Abstract: Background and Objectives The hypereosinophilic syndrome (HES) may be associated with the fusion of the platelet derived growth factor receptor α ( PDGFR α) gene with the FIP1L1 gene in chromosome 4 coding for a constitutively activated PDGFRα tyrosine kinase. These cases with FIP1L1-PDGFR α rearrangement have been reported to be very sensitive to the tyrosine kinase inhibitor imatinib mesylate.
Design and Methods A prospective multicenter study of idiopathic or primary HES was established in 2001 (Study Protocol Registration no. NCT 0027 6929). One hundred and ninety-six patients were screened, of whom 72 where identified as having idiopathic or primary HES and 63 were treated with imatinib 100 to 400 mg daily.
Results Twenty-seven male patients carried the FIP1L1-PDGFR α rearrangement. All 27 achieved a complete hematologic remission (CHR) and became negative for the fusion transcripts according to reverse transcriptase polymerase chain reaction (RT-PCR) analysis. With a median follow-up of 25 months (15–60 months) all 27 patients remain in CHR and RT-PCR negative, and continue treatment at a dose of 100 to 400 mg daily. In three patients imatinib treatment was discontinued for few months, the fusion transcript became rapidly detectable, and then again undetectable upon treatment reassumption. Thirty-six patients did not carry the rearrangement; of these, five (14%) achieved a CHR, which was lost in all cases after 1 to 15 months.
Interpretation and Conclusions All patients meeting the criteria for idiopathic or primary HES should be screened for the FIP1L1-PDGFR α rearrangement. For all patients with this rearrangement, chronic imatinib treatment at doses as low as 100 mg daily ensures complete and durable responses.
178 citations
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TL;DR: A search for heavy neutral Higgs bosons is performed using the LHC Run 2 data, corresponding to an integrated luminosity of 139 fb^{-1} of proton-proton collisions at sqrt[s]=13TeV recorded with the ATLAS detector.
Abstract: A search for heavy neutral Higgs bosons is performed using the LHC Run 2 data, corresponding to an integrated luminosity of 139 fb^{-1} of proton-proton collisions at sqrt[s]=13 TeV recorded with the ATLAS detector. The search for heavy resonances is performed over the mass range 0.2-2.5 TeV for the τ^{+}τ^{-} decay with at least one τ-lepton decaying into final states with hadrons. The data are in good agreement with the background prediction of the standard model. In the M_{h}^{125} scenario of the minimal supersymmetric standard model, values of tanβ>8 and tanβ>21 are excluded at the 95% confidence level for neutral Higgs boson masses of 1.0 and 1.5 TeV, respectively, where tanβ is the ratio of the vacuum expectation values of the two Higgs doublets.
178 citations
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01 Jan 2010-Microsystem Technologies-micro-and Nanosystems-information Storage and Processing Systems
TL;DR: In this article, the shape of scavengers is optimized to increase the specific power generated per unit of scavenger volume by optimizing shape of the scavengers, and two optimized trapezoidal configurations are identified and analyzed.
Abstract: Compact autonomous power sources are one of the prerequisites for the development of wireless sensor networks. In this work vibration energy harvesting via piezoelectric resonant bimorph beams is studied. The available analytical approaches for the modeling of the coupled electromechanical behavior are critically evaluated and compared with a finite element (FEM) numerical model. The latter is applied to analyze thoroughly the stress and strain states, as well as to evaluate the resulting voltage and charge distributions in the piezoelectric layers. The aim of increasing the specific power generated per unit of scavenger volume is pursued by optimizing the shape of the scavengers. Two optimized trapezoidal configurations are hence identified and analyzed. An experimental set-up for the validation of the proposed numerical model and of the obtained optimized structures is developed. Results of a preliminary experimental assessment, confirming the improved performances of optimized scavengers, are finally given.
177 citations
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TL;DR: The MBOat7 rs641738 T allele is associated with reduced MBOAT7 expression and may predispose to HCC in patients without cirrhosis, suggesting it should be evaluated in future prospective studies aimed at stratifying NAFLD-HCC risk.
Abstract: Nonalcoholic fatty liver disease (NAFLD) represents an emerging cause of hepatocellular carcinoma (HCC), especially in non-cirrhotic individuals. The rs641738 C > T MBOAT7/TMC4 variant predisposes to progressive NAFLD, but the impact on hepatic carcinogenesis is unknown. In Italian NAFLD patients, the rs641738 T allele was associated with NAFLD-HCC (OR 1.65, 1.08–2.55; n = 765), particularly in those without advanced fibrosis (p < 0.001). The risk T allele was linked to 3’-UTR variation in MBOAT7 and to reduced MBOAT7 expression in patients without severe fibrosis. The number of PNPLA3, TM6SF2, and MBOAT7 risk variants was associated with NAFLD-HCC independently of clinical factors (p < 0.001), but did not significantly improve their predictive accuracy. When combining data from an independent UK NAFLD cohort, in the overall cohort of non-cirrhotic patients (n = 913, 41 with HCC) the T allele remained associated with HCC (OR 2.10, 1.33–3.31). Finally, in a combined cohort of non-cirrhotic patients with chronic hepatitis C or alcoholic liver disease (n = 1121), the T allele was independently associated with HCC risk (OR 1.93, 1.07–3.58). In conclusion, the MBOAT7 rs641738 T allele is associated with reduced MBOAT7 expression and may predispose to HCC in patients without cirrhosis, suggesting it should be evaluated in future prospective studies aimed at stratifying NAFLD-HCC risk.
177 citations
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01 Nov 1982-International Journal of Human-computer Studies \/ International Journal of Man-machine Studies
TL;DR: The overall architecture of the goal oriented parsing system, along with the basic features of the parsing algorithm, are illustrated, based on the new concept of hierarchical parsing and is mainly directed by the semantics of the language.
Abstract: In this paper, a novel approach to natural language understanding, called goal oriented parsing, is presented. Such a model of comprehension is embedded in the more general frame of interpersonal communication and is applied to the person-machine interaction task. It is based on the claim that understanding imperative natural language is strongly dependent both on the goal of the speaker and on the nature of the hearer. This assumption has proved appropriate for the design of effective and robust natural language interfaces to artificial systems. This approach is supported by the development of an experimental project, called NLI, for enquiring in Italian a relational data base. NLI is to date running on a PDP 11/34 computer at the University of Udine. In this paper we illustrate the overall architecture of the system, along with the basic features of the parsing algorithm. This is based on the new concept of hierarchical parsing and is mainly directed by the semantics of the language. The role of clarification dialogue to overcome critical situations is discussed as well. The use of goal oriented parsing in dealing with full query text and anaphora is also exploited. Several meaningful examples are presented. Comparisons with related works are outlined and promising directions deserving further investigation are presented.
177 citations
Authors
Showing all 6857 results
Name | H-index | Papers | Citations |
---|---|---|---|
M.-Marsel Mesulam | 150 | 558 | 90772 |
Francesco Longo | 142 | 745 | 89859 |
Georges Aad | 135 | 1121 | 88811 |
Bobby Samir Acharya | 133 | 1121 | 100545 |
G. Della Ricca | 133 | 1598 | 92678 |
Marina Cobal | 132 | 1078 | 85437 |
Fernando Barreiro | 130 | 1082 | 83413 |
Saverio D'Auria | 129 | 1142 | 83684 |
Jean-Francois Grivaz | 128 | 1322 | 97758 |
Evgeny Starchenko | 128 | 864 | 75913 |
Muhammad Alhroob | 127 | 880 | 71982 |
Michele Pinamonti | 126 | 846 | 69328 |
Reisaburo Tanaka | 126 | 967 | 69849 |
Kerim Suruliz | 126 | 795 | 69456 |
Kate Shaw | 125 | 841 | 70087 |