Institution
University of Udine
Education•Udine, Italy•
About: University of Udine is a education organization based out in Udine, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 6745 authors who have published 20530 publications receiving 669088 citations. The organization is also known as: Università degli Studi di Udine & Universita degli Studi di Udine.
Topics: Population, Large Hadron Collider, Transplantation, Lepton, Higgs boson
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TL;DR: Transcripts of many NBS-LRR-encoding and related genes were defined, most were present at low levels and exhibited tissue-specific expression patterns, and no obvious correlation between expression pattern, phylogenetic relationship or genomic location was studied.
Abstract: Nucleotide binding site-leucine rich repeat (NBS-LRR)-encoding genes comprise the largest class of plant disease resistance genes. The 149 NBS-LRR-encoding genes and the 58 related genes that do not encode LRRs represent approximately 0.8% of all ORFs so far annotated in Arabidopsis ecotype Col-0. Despite their prevalence in the genome and functional importance, there was little information regarding expression of these genes. We analyzed the expression patterns of ~170 NBS-LRR-encoding and related genes in Arabidopsis Col-0 using multiple analytical approaches: expressed sequenced tag (EST) representation, massively parallel signature sequencing (MPSS), microarray analysis, rapid amplification of cDNA ends (RACE) PCR, and gene trap lines. Most of these genes were expressed at low levels with a variety of tissue specificities. Expression was detected by at least one approach for all but 10 of these genes. The expression of some but not the majority of NBS-LRR-encoding and related genes was affected by salicylic acid (SA) treatment; the response to SA varied among different accessions. An analysis of previously published microarray data indicated that ten NBS-LRR-encoding and related genes exhibited increased expression in wild-type Landsberg erecta (Ler) after flagellin treatment. Several of these ten genes also showed altered expression after SA treatment, consistent with the regulation of R gene expression during defense responses and overlap between the basal defense response and salicylic acid signaling pathways. Enhancer trap analysis indicated that neither jasmonic acid nor benzothiadiazole (BTH), a salicylic acid analog, induced detectable expression of the five NBS-LRR-encoding genes and one TIR-NBS-encoding gene tested; however, BTH did induce detectable expression of the other TIR-NBS-encoding gene analyzed. Evidence for alternative mRNA polyadenylation sites was observed for many of the tested genes. Evidence for alternative splicing was found for at least 12 genes, 11 of which encode TIR-NBS-LRR proteins. There was no obvious correlation between expression pattern, phylogenetic relationship or genomic location of the NBS-LRR-encoding and related genes studied. Transcripts of many NBS-LRR-encoding and related genes were defined. Most were present at low levels and exhibited tissue-specific expression patterns. Expression data are consistent with most Arabidopsis NBS-LRR-encoding and related genes functioning in plant defense responses but do not preclude other biological roles.
173 citations
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TL;DR: The overall risk of NHL in patients with CS is about 35 times higher than in the general population (12 times higher if nonaggressive lymphomas are excluded), and the presence of CS did not significantly affect the treatment of newly diagnosed lymphomas.
Abstract: fied as nonaggressive in 31 cases (53%), aggressive in 20 (34%), and mucosa-associated lymphoid tissue lymphomas in 6 (10%); 2 cases were unclassifiable The median timefromthediagnosisofCStotheclinicalonsetofNHL was626years(range,081-24years)Theclinicalcourse and response to chemotherapy in the patients with CS who had NHL were similar to those usually described in patients with NHL without CS; the course of the CS only marginally benefited from chemotherapy Conclusions: The overall risk of NHL in patients with CS is about 35 times higher than in the general population(12timeshigherifnonaggressivelymphomasareexcluded) The presence of CS did not significantly affect the treatment of newly diagnosed lymphomas Arch Intern Med 2005;165:101-105
173 citations
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TL;DR: It is shown that it is possible to obtain an efficient chatter detection system both in terms of accuracy and of robustness against malfunctions and compatible with modern machine tool operation and automation.
172 citations
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TL;DR: The best characterized functions of cyclophilin D in mitochondria are reviewed, i.e. regulation of the permeability transition pore, an inner membrane channel that plays an important role in the execution of cell death.
172 citations
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TL;DR: The whole body of the fish fed diets with the highest crude fat and NFE levels had significantly lower contents of moisture and protein and a higher level of crude fat, while the saturated, monunsaturated and n - 6 polyunsaturated fatty acids of fish muscle significantly decreased while n - 3 PUFA levels significantly increased with increasing dietary fat content.
172 citations
Authors
Showing all 6857 results
Name | H-index | Papers | Citations |
---|---|---|---|
M.-Marsel Mesulam | 150 | 558 | 90772 |
Francesco Longo | 142 | 745 | 89859 |
Georges Aad | 135 | 1121 | 88811 |
Bobby Samir Acharya | 133 | 1121 | 100545 |
G. Della Ricca | 133 | 1598 | 92678 |
Marina Cobal | 132 | 1078 | 85437 |
Fernando Barreiro | 130 | 1082 | 83413 |
Saverio D'Auria | 129 | 1142 | 83684 |
Jean-Francois Grivaz | 128 | 1322 | 97758 |
Evgeny Starchenko | 128 | 864 | 75913 |
Muhammad Alhroob | 127 | 880 | 71982 |
Michele Pinamonti | 126 | 846 | 69328 |
Reisaburo Tanaka | 126 | 967 | 69849 |
Kerim Suruliz | 126 | 795 | 69456 |
Kate Shaw | 125 | 841 | 70087 |