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Institution

University of Udine

EducationUdine, Italy
About: University of Udine is a education organization based out in Udine, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 6745 authors who have published 20530 publications receiving 669088 citations. The organization is also known as: Università degli Studi di Udine & Universita degli Studi di Udine.


Papers
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Journal ArticleDOI
TL;DR: Reactive oxygen species accumulation in the BM is an upstream consequence of ovariectomy that leads to bone loss by activating T cells through enhanced activity of BM dendritic cells, and these findings suggest that the CD80/CD28 pathway may represent a therapeutic target for postmenopausal bone loss.
Abstract: Increased production of tumor necrosis factor α (TNF) in the bone marrow (BM) in response to both oxidative stress and T cell activation contributes to the bone loss induced by estrogen deficiency, but it is presently unknown whether oxidative stress causes bone loss through T cells. Here we show that ovariectomy causes an accumulation in the BM of reactive oxygen species, which leads to increased production of TNF by activated T cells through up-regulation of the costimulatory molecule CD80 on dendritic cells. Accordingly, bone loss is prevented by treatment of ovariectomized mice with either antioxidants or CTLA4-Ig, an inhibitor of the CD80/CD28 pathway. In summary, reactive oxygen species accumulation in the BM is an upstream consequence of ovariectomy that leads to bone loss by activating T cells through enhanced activity of BM dendritic cells, and these findings suggest that the CD80/CD28 pathway may represent a therapeutic target for postmenopausal bone loss.

132 citations

Journal ArticleDOI
TL;DR: From the multivariate analysis, congestive heart failure, stroke, prosthetic valve infection, S. aureus, and health care-associated acquisition were independently associated with increased in-hospital mortality, while surgery was associated with decreased mortality.
Abstract: The characteristics of patients with infective endocarditis (IE) vary significantly by region of the world. The aim of this study was to evaluate the contemporary epidemiology, characteristics, and outcome of IE in a large, nationwide cohort of Italian patients. We conducted a prospective, observational study at 24 medical centers in Italy, including all the consecutive patients with a definite or possible diagnosis of IE (modified Duke criteria) admitted from January 2004 through December 2009. A number of clinical variables were collected through an electronic case report form and analyzed to comprehensively delineate the features of IE. We report the data on patients with definite IE. A total of 1,082 patients with definite IE were included. Of these, 753 (69.6 %) patients had infection on a native valve, 277 (25.6 %) on a prosthetic valve, and 52 (4.8 %) on an implantable electronic device. Overall, community-acquired (69.2 %) was more common than nosocomial (6.2 %) or non-nosocomial (24.6 %) health care-associated IE. Staphylococcus aureus was the most common pathogen (22.0 %). In-hospital mortality was 15.1 %. From the multivariate analysis, congestive heart failure (CHF), stroke, prosthetic valve infection, S. aureus, and health care-associated acquisition were independently associated with increased in-hospital mortality, while surgery was associated with decreased mortality. The current mortality of IE remains high, and is mainly due to its complications, such as CHF and stroke.

132 citations

Journal ArticleDOI
Georges Aad1, Brad Abbott2, J. Abdallah3, S. Abdel Khalek4  +3034 moreInstitutions (177)
TL;DR: In this paper, a measurement of the cross section of single top-quark production in the t-channel using 1.04 fb -1 of pp collision data at s=7 TeV recorded with the ATLAS detector at the LHC is presented.

132 citations

Journal ArticleDOI
Jelena Aleksić1, L. A. Antonelli2, P. Antoranz3, Michael Backes4  +156 moreInstitutions (22)
TL;DR: In this paper, the authors reproduce the observed spectral energy density by using the structured jet (spine-layer) model which has previously been adopted to explain the high-energy emission of radio galaxies.
Abstract: The Perseus galaxy cluster was observed by the MAGIC Cherenkov telescope for a total effective time of 24.4 hr during 2008 November and December. The resulting upper limits on the gamma-ray emission above 100 GeV are in the range of 4.6 to 7.5 x 10^{-12} cm^{-2} s^{-1} for spectral indices from -1.5 to -2.5, thereby constraining the emission produced by cosmic rays, dark matter annihilations, and the central radio galaxy NGC1275. Results are compatible with cosmological cluster simulations for the cosmic-ray-induced gamma-ray emission, constraining the average cosmic ray-to-thermal pressure to <4% for the cluster core region (<8% for the entire cluster). Using simplified assumptions adopted in earlier work (a power-law spectrum with an index of -2.1, constant cosmic ray-to-thermal pressure for the peripheral cluster regions while accounting for the adiabatic contraction during the cooling flow formation), we would limit the ratio of cosmic ray-to-thermal energy to E_CR/E_th<3%. The upper limit also translates into a level of gamma-ray emission from possible annihilations of the cluster dark matter (the dominant mass component) that is consistent with boost factors of ~10^4 for the typically expected dark matter annihilation-induced emission. Finally, the upper limits obtained for the gamma-ray emission of the central radio galaxy NGC1275 are consistent with the recent detection by the Fermi-LAT satellite. Due to the extremely large Doppler factors required for the jet, a one-zone synchrotron self-Compton model is implausible in this case. We reproduce the observed spectral energy density by using the structured jet (spine-layer) model which has previously been adopted to explain the high-energy emission of radio galaxies.

132 citations

Journal ArticleDOI
TL;DR: A large survey was carried out in 2008 in Europe to evaluate the efficacy of fenbendazole (FBZ), pyrantel (PYR), ivermectin (IVM) and moxidectin(MOX), i.e. the major anthelmintic molecules used in current practice against cyathostomins affecting horses as discussed by the authors.
Abstract: A large survey was carried out in 2008 in Europe to evaluate the efficacy of fenbendazole (FBZ), pyrantel (PYR), ivermectin (IVM) and moxidectin (MOX), i.e. the major anthelmintic molecules used in current practice against cyathostomins affecting horses. A total of 102 yards and 1704 horses was studied in three countries: 60 yards and 988 horses from Italy, 22 and 396 from the UK, 20 and 320 from Germany. The survey consisted of Faecal Egg Count Reduction Tests (FECRTs) with a faecal egg count reduction (FECR) categorization of (I) resistance present if FECR 90%. The calculation of FECR data was performed employing bootstrap analysis of group arithmetic means. The testing of FBZ on a total of 80 yards resulted in resistance present on more than 80% of the UK and German yards and on significantly fewer in Italy, i.e. in 38% (p < 0.01). PYR, IVM and MOX were tested on a total of 102 yards. For PYR resistance present was found in 25% of the yards with no significant differences between countries. For IVM resistance present was encountered in one Italian and two UK yards (3%), resistance present to MOX was not found in any yard in any country. The results indicate that single and/or multiple drug resistance in equine cyathostomins is present in the three countries, is widespread particularly for FBZ and/or PYR and in one UK yard multiple resistance present was detected to FBZ, PYR and IVM. Macrocylic lactones proved to be the most effective drugs, with some evidence of resistance to IVM and highest activity of MOX, despite a single case of reduced efficacy in Germany. These data call for the development and implementation, among practitioners, owners and managers, of further plans to reduce the expansion of the anthelmintic resistant populations and to use those anthelmintics that remain effective in a manner that preserves their efficacy as long as possible.

132 citations


Authors

Showing all 6857 results

NameH-indexPapersCitations
M.-Marsel Mesulam15055890772
Francesco Longo14274589859
Georges Aad135112188811
Bobby Samir Acharya1331121100545
G. Della Ricca133159892678
Marina Cobal132107885437
Fernando Barreiro130108283413
Saverio D'Auria129114283684
Jean-Francois Grivaz128132297758
Evgeny Starchenko12886475913
Muhammad Alhroob12788071982
Michele Pinamonti12684669328
Reisaburo Tanaka12696769849
Kerim Suruliz12679569456
Kate Shaw12584170087
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202350
2022142
20211,338
20201,388
20191,223
20181,102