University of Udine

About: University of Udine is a education organization based out in Udine, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 6745 authors who have published 20530 publications receiving 669088 citations. The organization is also known as: Università degli Studi di Udine & Universita degli Studi di Udine.

Proteins as biomarkers of oxidative/nitrosative stress in diseases: The contribution of redox proteomics

Abstract: I. Introduction 00 II. Reactive Oxygen and Nitrogen Species 00 III. Biological Markers of Oxidative/Nitrosative Stress 00 IV. Oxidative/Nitrosative Stress and Protein Modifications 00 A. Oxidative/Nitrosative Modification of Protein Thiols 00 B. Oxidative/Nitrosative Modification of Tyrosine 00 C. Oxidative Modification of Methionine 00 D. Protein Carbonylation 00 E. Oxidative Modification of Histidine and Tryptophan 00 V. MS Approaches for the Molecular Characterization of Oxidatively/Nitrosatively Modified Proteins 00 A. Analysis of Oxidized/Nitrosated Products of Protein Thiols 00 B. Analysis of Oxidized/Nitrated Products of Tyrosine Residues 00 C. Analysis of Oxidized Products of Methionine Residues 00 D. Analysis of Protein Carbonylation Products 00 E. Analysis of Oxidized Products of Tryptophan Residues 00 F. Analysis of Oxidized Products of Histidine Residues 00 VI. Proteomic Strategies for the Identification of ROS/RNS Targets in Complex Protein Mixtures 00 VII. Selected Human Diseases Associated with Oxidative/Nitrosative Stress 00 A. Acute (Adult) Respiratory Distress Syndrome 00 B. Alzheimer's Disease 00 C. Amyotrophic Lateral Sclerosis 00 D. Asthma 00 E. Atherosclerosis 00 F. Chronic Obstructive Pulmonary Diseases 00 G. Diabetes Mellitus 00 H. HIV Infection 00 I. Preeclampsia 00 J. Rheumatoid Arthritis 00 K. Transmissible Spongiform Encephalopathies 00 VIII. Oxidatively Modified Proteins in Human Diseases 00 IX. Concluding Remarks and Future Perspectives 00 Acknowledgments 00 Abbreviations 00 References 00 Reactive oxygen species (ROS) and reactive nitrogen species (RNS) contribute to the pathogenesis and/or progression of several human diseases. Proteins are important molecular signposts of oxidative/nitrosative damage. However, it is generally unresolved whether the presence of oxidatively/nitrosatively modified proteins has a causal role or simply reflects secondary epiphenomena. Only direct identification and characterization of the modified protein(s) in a given pathophysiological condition can decipher the potential roles played by ROS/RNS-induced protein modifications. During the last few years, mass spectrometry (MS)-based technologies have contributed in a significant way to foster a better understanding of disease processes. The study of oxidative/nitrosative modifications, investigated by redox proteomics, is contributing to establish a relationship between pathological hallmarks of disease and protein structural and functional abnormalities. MS-based technologies promise a contribution in a new era of molecular medicine, especially in the discovery of diagnostic biomarkers of oxidative/nitrosative stress, enabling early detection of diseases. Indeed, identification and characterization of oxidatively/nitrosatively modified proteins in human diseases has just begun. © 2004 Wiley Periodicals, Inc., Mass Spec Rev

Performance of the ATLAS Trigger System in 2010

Abstract: Proton-proton collisions at root s = 7 TeV and heavy ion collisions at root(NN)-N-s = 2.76 TeV were produced by the LHC and recorded using the ATLAS experiment's trigger system in 2010. The LHC is designed with a maximum bunch crossing rate of 40 MHz and the ATLAS trigger system is designed to record approximately 200 of these per second. The trigger system selects events by rapidly identifying signatures of muon, electron, photon, tau lepton, jet, and B meson candidates, as well as using global event signatures, such as missing transverse energy. An overview of the ATLAS trigger system, the evolution of the system during 2010 and the performance of the trigger system components and selections based on the 2010 collision data are shown. A brief outline of plans for the trigger system in 2011 is presented.

Review on iron availability in soil: interaction of Fe minerals, plants, and microbes

Abstract: Purpose The rationale of this paper is to review the state of the art regarding the biotic and abiotic reactions that can influence Fe availability in soils. In soil, the management-induced change from oxic to anoxic environment results in temporal and spatial variations of redox reactions, which, in turn, affect the Fe dynamics and Fe mineral constituents. Measuring the Fe forms in organic complexes and the interaction between bacteria and Fe is a major challenge in getting a better quantitative understanding of the dynamics of Fe in complex soil ecosystems.

Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √=s=8 TeV with the ATLAS detector

Abstract: Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb(-1) of root s = 8 TeV data collected in 2012 ...

Fluid challenges in intensive care: the FENICE study: A global inception cohort study

Abstract: Background Fluid challenges (FCs) are one of the most commonly used therapies in critically ill patients and represent the cornerstone of hemodynamic management in intensive care units. There are clear benefits and harms from fluid therapy. Limited data on the indication, type, amount and rate of an FC in critically ill patients exist in the literature. The primary aim was to evaluate how physicians conduct FCs in terms of type, volume, and rate of given fluid; the secondary aim was to evaluate variables used to trigger an FC and to compare the proportion of patients receiving further fluid administration based on the response to the FC.