Institution
University of Udine
Education•Udine, Italy•
About: University of Udine is a education organization based out in Udine, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 6745 authors who have published 20530 publications receiving 669088 citations. The organization is also known as: Università degli Studi di Udine & Universita degli Studi di Udine.
Topics: Population, Large Hadron Collider, Transplantation, Lepton, Higgs boson
Papers published on a yearly basis
Papers
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TL;DR: The data recorded by these instruments during their first and second observing runs are described, including the gravitational-wave strain arrays, released as time series sampled at 16384 Hz.
320 citations
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TL;DR: GapFiller, starting from a sufficiently high short reads coverage, is able to produce high coverages of accurate longer sequences (from 300 bp up to 3500 bp) and turned out to be a powerful criterion to guarantee contigs' correctness.
Abstract: Background
Next Generation Sequencing technologies are able to provide high genome coverages at a relatively low cost. However, due to limited reads' length (from 30 bp up to 200 bp), specific bioinformatics problems have become even more difficult to solve. De novo assembly with short reads, for example, is more complicated at least for two reasons: first, the overall amount of "noisy" data to cope with increased and, second, as the reads' length decreases the number of unsolvable repeats grows. Our work's aim is to go at the root of the problem by providing a pre-processing tool capable to produce (in-silico) longer and highly accurate sequences from a collection of Next Generation Sequencing reads.
318 citations
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TL;DR: The finding of the clinical efficacy of selective B cell blockade indicates that B cells play a critical role in rheumatoid synovitis, at least in a subset of patients.
Abstract: Objective
The pathogenetic role of B cells in rheumatoid arthritis (RA) is under debate, but it is currently believed to be marginal. The availability of selective anti–B cell treatment provides a unique opportunity to clarify this issue. This study was undertaken to investigate the effects of B cell blockade in the treatment of refractory RA, and to evaluate the implications with regard to the role of B cells in the disease.
Methods
Five female patients with active, evolving erosive RA were treated with rituximab, an anti-CD20 chimeric monoclonal antibody. All 5 patients had been nonresponders to combination therapy with methotrexate plus cyclosporin A. Two of the 5 had also failed to respond to anti–tumor necrosis factor α therapy. All of these treatments were discontinued 1 month before institution of anti-CD20 therapy.
Results
Marked clinical improvement was observed in 2 patients (American College of Rheumatology 70% response [ACR70] and ACR50, respectively), starting at the end of the second month after institution of anti-CD20 therapy (month 2) and lasting until month 10 in 1 patient (articular relapse) and month 12 in the other (last followup). ACR20 response was observed in 2 additional patients, lasting until month 5 and month 7, respectively (articular relapse in both). Decrease or normalization of serum C-reactive protein and rheumatoid factor levels were observed in these patients. In contrast, patient 3 had no response to the treatment. RA synovitis and evolving erosive damage were decreased in patients exhibiting a major response, as demonstrated by imaging studies.
Conclusion
Our finding of the clinical efficacy of selective B cell blockade indicates that B cells play a critical role in rheumatoid synovitis, at least in a subset of patients. Qualitative or quantitative differences in B cell commitment in RA pathobiology might have a function in the different responses observed.
317 citations
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TL;DR: The methods employed in the ATLAS experiment to correct for the impact of pile-up on jet energy and jet shapes, and for the presence of spurious additional jets, are described, with a primary focus on the large 20.3 kg-1 data sample.
Abstract: The large rate of multiple simultaneous protonproton interactions, or pile-up, generated by the Large Hadron Collider in Run 1 required the development of many new techniques to mitigate the advers ...
316 citations
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TL;DR: The most common paraganglioma of the head and neck is the carotid body tumor followed by the jugulo-tympanic and vagal varieties, and other rare sites where this tumor may occur include; the larynx, sinonasal chambers and orbit.
310 citations
Authors
Showing all 6857 results
Name | H-index | Papers | Citations |
---|---|---|---|
M.-Marsel Mesulam | 150 | 558 | 90772 |
Francesco Longo | 142 | 745 | 89859 |
Georges Aad | 135 | 1121 | 88811 |
Bobby Samir Acharya | 133 | 1121 | 100545 |
G. Della Ricca | 133 | 1598 | 92678 |
Marina Cobal | 132 | 1078 | 85437 |
Fernando Barreiro | 130 | 1082 | 83413 |
Saverio D'Auria | 129 | 1142 | 83684 |
Jean-Francois Grivaz | 128 | 1322 | 97758 |
Evgeny Starchenko | 128 | 864 | 75913 |
Muhammad Alhroob | 127 | 880 | 71982 |
Michele Pinamonti | 126 | 846 | 69328 |
Reisaburo Tanaka | 126 | 967 | 69849 |
Kerim Suruliz | 126 | 795 | 69456 |
Kate Shaw | 125 | 841 | 70087 |