Institution
University of Udine
Education•Udine, Italy•
About: University of Udine is a education organization based out in Udine, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 6745 authors who have published 20530 publications receiving 669088 citations. The organization is also known as: Università degli Studi di Udine & Universita degli Studi di Udine.
Topics: Population, Large Hadron Collider, Transplantation, Lepton, Higgs boson
Papers published on a yearly basis
Papers
More filters
••
TL;DR: A Pin1/mutant p53 axis that conveys oncogenic signals to promote aggressiveness in human cancers is defined and a transcriptional signature associated with poor prognosis in breast cancer and Pin1 overexpression influenced the prognostic value of p53 mutation is identified.
259 citations
••
TL;DR: A short-term incubation study was carried out to investigate the effect of biochar addition to soil on CO 2 emissions, microbial biomass, soil soluble carbon (C) nitrogen (N) and nitrate-nitrogen (NO 3 -N) as discussed by the authors.
259 citations
••
TL;DR: It is demonstrated that vitamin E administration may reduce protein glycosylation in diabetic subjects independently of changes in plasma glucose, an effect that may be due to the inhibition of labile gly cosylation, the first step of the Maillard reaction.
Abstract: Objective This study evaluated the possibility of inhibiting protein glycosylation in vivo with vitamin E. Research Design and Methods Two groups of 10 insulin-requiring diabetic patients, matched for duration of disease and metabolic control, received daily vitamin E supplementation of 1200 and 600 mg, respectively, for 2 mo. A third group of 10 diabetic patients, matched for duration of disease and metabolic control, served as the control group and received placebo. Fasting plasma glucose, mean daily plasma glucose, fasting labile HbA 1 , and glycosylated proteins were measured in the basal state and after 1 and 2 mo of treatment. In addition, hyperglycemic clamp studies were performed in basal state and after 1 mo of vitamin E administration in all patients. Results Glycemic indices did not show any significant changes during the study, whereas fasting labile HbA, and glycosylated proteins decreased significantly after 1 and 2 mo in patients on vitamin E administration. Stable HbA 1 decreased after 2 mo. Mean glycemic incremental area in the hyperglycemic clamp procedure was similar before and after treatment, whereas a significant reduction in mean labile HbA 1 incremental area was found after vitamin E supplementation. A significant difference was also found in both fasting and incremental labile HbA 1 levels, stable HbA 1 , and glycosylated proteins between the two groups of diabetic patients on the two doses of vitamin E; the diabetic patients who received the higher dose of vitamin E showed the greater reduction. No significant changes in these parameters were observed in diabetic patients on placebo administration. Conclusions These results demonstrate that vitamin E administration may reduce protein glycosylation in diabetic subjects independently of changes in plasma glucose, an effect that may be due to the inhibition of labile glycosylation, the first step of the Maillard reaction. Long-term studies will help establish the usefulness of vitamin E administration for the prevention of diabetic complications.
257 citations
••
University of Würzburg1, IFAE2, ETH Zurich3, Complutense University of Madrid4, Autonomous University of Barcelona5, Max Planck Society6, University of Padua7, Technical University of Dortmund8, University of Barcelona9, Yerevan Physics Institute10, University of La Laguna11, Spanish National Research Council12, University of Udine13, University of Siena14, University of California, Davis15, Humboldt University of Berlin16, INAF17, University of Pisa18, Institut de Ciències de l'Espai19
TL;DR: The MAGIC observations were performed for a total of 40 hours during 26 nights, spanning the period between 2006 June and November, and the results from the observations in the very high energy band (VHE; GeV) of the black E = 100 g hole X-ray binary (BHXB) Cygnus X-1 were reported in this article.
Abstract: We report on the results from the observations in the very high energy band ( VHE; GeV) of the black E = 100 g hole X- ray binary ( BHXB) Cygnus X- 1. The observations were performed with the MAGIC telescope, for a total of 40 hr during 26 nights, spanning the period between 2006 June and November. Searches for steady gamma - ray signals yielded no positive result, and upper limits to the integral flux ranging between 1% and 2% of the Crab Nebula flux, depending on the energy, have been established. We also analyzed each observation night independently, obtaining evidence of gamma- ray signals at the 4.0 j significance level ( 3.2 j after trial correction) for 154 minutes of effective on- time ( EOT) on September 24 between 20: 58 and 23: 41 UTC, coinciding with an X- ray flare seen by RXTE, Swift, and INTEGRAL. A search for faster- varying signals within a night resulted in an excess with a significance of 4.9 j ( 4.1 j after trial correction) for 79 minutes EOT between 22: 17 and 23: 41 UTC. The measured excess is compatible with a pointlike source at the position of Cygnus X- 1 and excludes the nearby radio nebula powered by its relativistic jet. The differential energy spectrum is well fitted by an unbroken power law described as dN/(dA dt dE) = ( 2.3 +/- 0.6)* 10 ( E/1TeV). This is the first experimental evidence of VHE emission from a stellar mass black hole and therefore from a confirmed accreting X- ray binary.
257 citations
••
TL;DR: A functional link between proliferation and invasion of tumor cells is provided based on diverse activities of p27 kip1 in different subcellular compartments and high stathmin and low cytoplasmic p27kip1 expression correlate with the metastatic phenotype of human sarcomas in vivo.
256 citations
Authors
Showing all 6857 results
Name | H-index | Papers | Citations |
---|---|---|---|
M.-Marsel Mesulam | 150 | 558 | 90772 |
Francesco Longo | 142 | 745 | 89859 |
Georges Aad | 135 | 1121 | 88811 |
Bobby Samir Acharya | 133 | 1121 | 100545 |
G. Della Ricca | 133 | 1598 | 92678 |
Marina Cobal | 132 | 1078 | 85437 |
Fernando Barreiro | 130 | 1082 | 83413 |
Saverio D'Auria | 129 | 1142 | 83684 |
Jean-Francois Grivaz | 128 | 1322 | 97758 |
Evgeny Starchenko | 128 | 864 | 75913 |
Muhammad Alhroob | 127 | 880 | 71982 |
Michele Pinamonti | 126 | 846 | 69328 |
Reisaburo Tanaka | 126 | 967 | 69849 |
Kerim Suruliz | 126 | 795 | 69456 |
Kate Shaw | 125 | 841 | 70087 |