University of Udine

About: University of Udine is a education organization based out in Udine, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 6745 authors who have published 20530 publications receiving 669088 citations. The organization is also known as: Università degli Studi di Udine & Universita degli Studi di Udine.

Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression

Abstract: Morphometric MRI studies suggest decreased hippocampal volumes in currently depressed patients, with conflicting findings for the amygdala. We studied these temporal lobe structures and superior temporal gyrus (STG) in patients with current and remitted major depression. We scanned 31 unmedicated depressed patients (21 currently depressed, 10 remitted) and 31 matched healthy controls with a 3D SPGR sequence in a 1.5 Tesla GE Signa Imaging System. There was a trend towards smaller left amygdala volumes in all depressed patients compared with healthy controls. We found significantly smaller hippocampal volumes bilaterally in currently depressed patients than in remitted patients. Furthermore, we found a statistically significant inverse correlation between length of illness and left hippocampus volumes and right superior temporal gyrus volumes. Our finding of smaller hippocampi in currently depressed patients is consistent with the hypothesis that hypercortisolism could result in hippocampal neurotoxicity in major depression. A smaller hippocampal size may be more characteristic of the depressive state and not be present in remitted patients.

Search for high-mass diboson resonances with boson-tagged jets in proton-proton collisions at √s=8 TeV with the ATLAS detector

Abstract: A search is performed for narrow resonances decaying into WW, WZ, or ZZ boson pairs using 20.3 fb(-1) of proton-proton collision data at a centre-of-mass energy of root s = TeV recorded with the AT ...

Fate of gravitational collapse in semiclassical gravity

Abstract: While the outcome of gravitational collapse in classical general relativity is unquestionably a black hole, up to now no full and complete semiclassical description of black hole formation has been thoroughly investigated. Here we revisit the standard scenario for this process. By analyzing how semiclassical collapse proceeds we show that the very formation of a trapping horizon can be seriously questioned for a large set of, possibly realistic, scenarios. We emphasize that in principle the theoretical framework of semiclassical gravity certainly allows the formation of trapping horizons. What we are questioning here is the more subtle point of whether or not the standard black hole picture is appropriate for describing the end point of realistic collapse. Indeed if semiclassical physics were in some cases to prevent formation of the trapping horizon, then this suggests the possibility of new collapsed objects which can be much less problematic, making it unnecessary to confront the information paradox or the runaway end point problem.

TREAT-AND-EXTEND REGIMENS WITH ANTI-VEGF AGENTS IN RETINAL DISEASES: A Literature Review and Consensus Recommendations

Abstract: PURPOSE A review of treat-and-extend regimens (TERs) with intravitreal anti-vascular endothelial growth factor agents in retinal diseases. METHODS There is a lack of consensus on the definition and optimal application of TER in clinical practice. This article describes the supporting evidence and subsequent development of a generic algorithm for TER dosing with anti-vascular endothelial growth factor agents, considering factors such as criteria for extension. RESULTS A TER algorithm was developed; TER is defined as an individualized proactive dosing regimen usually initiated by monthly injections until a maximal clinical response is observed (frequently determined by optical coherence tomography), followed by increasing intervals between injections (and evaluations) depending on disease activity. The TER regimen has emerged as an effective approach to tailoring the dosing regimen and for reducing treatment burden (visits and injections) compared with fixed monthly dosing or monthly visits with optical coherence tomography-guided regimens (as-needed or pro re nata). It is also considered a suitable approach in many retinal diseases managed with intravitreal anti-vascular endothelial growth factor therapy, given that all eyes differ in the need for repeat injections. CONCLUSION It is hoped that this practical review and TER algorithm will be of benefit to health care professionals interested in the management of retinal diseases.