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Institution

University of Utah

EducationSalt Lake City, Utah, United States
About: University of Utah is a education organization based out in Salt Lake City, Utah, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 52894 authors who have published 124076 publications receiving 5265834 citations. The organization is also known as: The U & The University of Utah.


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Journal ArticleDOI
TL;DR: It is reported that in glomeruli of rats made diabetic there is a slow, progressive increase in the expression of transforming growth factor beta (TGF- beta) mRNA and TGF-beta protein, which implicate TGF -beta in the pathogenesis of diabetic nephropathy.
Abstract: Diabetes is now the most common cause of progressive kidney failure leading to dialysis or transplantation. The central pathological feature of diabetic nephropathy is accumulation of extracellular matrix within the glomeruli. The factors in the diabetic milieu responsible for extracellular matrix accumulation are not understood. Here we report that in glomeruli of rats made diabetic there is a slow, progressive increase in the expression of transforming growth factor beta (TGF-beta) mRNA and TGF-beta protein. A key action of TGF-beta is induction of extracellular matrix production, and specific matrix proteins known to be induced by TGF-beta were increased in diabetic rat glomeruli. These proteins include an alternatively spliced form of fibronectin, tenascin, and the proteoglycan biglycan. TGF-beta has not previously been implicated in the matrix accumulation that occurs in the diabetic kidney. Glomeruli from humans with diabetic nephropathy also showed a striking increase in immunoreactive TGF-beta protein and deposition of the special form of fibronectin, whereas glomeruli from normal subjects or from individuals with other glomerular diseases (where extracellular matrix accumulation is not a feature) were negative or barely positive. These results implicate TGF-beta in the pathogenesis of diabetic nephropathy.

823 citations

Journal ArticleDOI
TL;DR: Almost 11 years of follow-up showed that the efficacy of Imatinib persisted over time and that long‐term administration of imatinib was not associated with unacceptable cumulative or late toxic effects.
Abstract: BackgroundImatinib, a selective BCR-ABL1 kinase inhibitor, improved the prognosis for patients with chronic myeloid leukemia (CML). We conducted efficacy and safety analyses on the basis of more than 10 years of follow-up in patients with CML who were treated with imatinib as initial therapy. MethodsIn this open-label, multicenter trial with crossover design, we randomly assigned patients with newly diagnosed CML in the chronic phase to receive either imatinib or interferon alfa plus cytarabine. Long-term analyses included overall survival, response to treatment, and serious adverse events. ResultsThe median follow-up was 10.9 years. Given the high rate of crossover among patients who had been randomly assigned to receive interferon alfa plus cytarabine (65.6%) and the short duration of therapy before crossover in these patients (median, 0.8 years), the current analyses focused on patients who had been randomly assigned to receive imatinib. Among the patients in the imatinib group, the estimated overall s...

823 citations

Journal ArticleDOI
TL;DR: In this paper, the evolution of integrated virus genomes (prophages) is analyzed using nucleotide sequence analysis, and it is shown that some prophages can lie in residence for very long times, perhaps millions of years, and that recombination events have occurred between related Prophages that reside at different locations in a bacterium's genome.
Abstract: Epigraph There is something fascinating about science. One gets such wholesale returns of conjecture out of such a trifling investment of fact. Mark Twain 1883 Life on the Mississippi Summary Bacterial genome nucleotide sequences are being completed at a rapid and increasing rate. Integrated virus genomes (prophages) are common in such genomes. Fifty-one of the 82 such genomes published to date carry prophages, and these contain 230 recognizable putative prophages. Prophages can constitute as much as 10–20% of a bacterium's genome and are major contributors to differences between individuals within species. Many of these prophages appear to be defective and are in a state of mutational decay. Prophages, including defective ones, can contribute important biological properties to their bacterial hosts. Therefore, if we are to comprehend bacterial genomes fully, it is essential that we are able to recognize accurately and understand their prophages from nucleotide sequence analysis. Analysis of the evolution of prophages can shed light on the evolution of both bacteriophages and their hosts. Comparison of the Rac prophages in the sequenced genomes of three Escherichia coli strains and the Pnm prophages in two Neisseria meningitidis strains suggests that some prophages can lie in residence for very long times, perhaps millions of years, and that recombination events have occurred between related prophages that reside at different locations in a bacterium's genome. In addition, many genes in defective prophages remain functional, so a significant portion of the temperate bacteriophage gene pool resides in prophages.

822 citations

Journal ArticleDOI
11 Apr 1991-Nature
TL;DR: Gene targeting in mouse embryo-derived stem cells has been used to disrupt the homeobox gene hox-1.5, and homozygotes are athymic, aparathyroid, have reduced thyroid and submaxillary tissue and exhibit a wide range of throat abnormalities.
Abstract: Gene targeting in mouse embryo-derived stem cells has been used to disrupt the homeobox gene hox-1.5. Mice heterozygous at the hox-1.5 locus appear normal, whereas hox-1.5-/hox-1.5- mice die at or shortly after birth. These homozygotes are athymic, aparathyroid, have reduced thyroid and submaxillary tissue and exhibit a wide range of throat abnormalities. In addition, they often feature defects of the heart and arteries as well as craniofacial abnormalities. These deficiencies are remarkably similar to the pathology of the human congenital disorder DiGeorge's syndrome.

820 citations

Journal ArticleDOI
19 Mar 2004-Cell
TL;DR: It is shown that Norrin and Fz4 function as a ligand-receptor pair that plays a central role in vascular development in the eye and ear, and it is indicated that ligands unrelated to Wnts can act through Fz receptors.

818 citations


Authors

Showing all 53431 results

NameH-indexPapersCitations
Bert Vogelstein247757332094
George M. Whitesides2401739269833
Hongjie Dai197570182579
Robert M. Califf1961561167961
Frank E. Speizer193636135891
Yusuke Nakamura1792076160313
David L. Kaplan1771944146082
Marc G. Caron17367499802
George M. Church172900120514
Steven P. Gygi172704129173
Lily Yeh Jan16246773655
Tobin J. Marks1591621111604
David W. Bates1591239116698
Alfred L. Goldberg15647488296
Charles M. Perou156573202951
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023203
2022769
20217,363
20207,015
20196,309
20185,651