University of Utah

About: University of Utah is a education organization based out in Salt Lake City, Utah, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 52894 authors who have published 124076 publications receiving 5265834 citations. The organization is also known as: The U & The University of Utah.

Safety of Anacetrapib in Patients with or at High Risk for Coronary Heart Disease

Abstract: Background Anacetrapib is a cholesteryl ester transfer protein inhibitor that raises high-density lipoprotein (HDL) cholesterol and reduces low-density lipoprotein (LDL) cholesterol. Methods We conducted a randomized, double-blind, placebo-controlled trial to assess the efficacy and safety profile of anacetrapib in patients with coronary heart disease or at high risk for coronary heart disease. Eligible patients who were taking a statin and who had an LDL cholesterol level that was consistent with that recommended in guidelines were assigned to receive 100 mg of anacetrapib or placebo daily for 18 months. The primary end points were the percent change from baseline in LDL cholesterol at 24 weeks (HDL cholesterol level was a secondary end point) and the safety and side-effect profile of anacetrapib through 76 weeks. Cardiovascular events and deaths were prospectively adjudicated. Results A total of 1623 patients underwent randomization. By 24 weeks, the LDL cholesterol level had been reduced from 81 mg per...

Rheology of concentrated suspensions

Abstract: The dependence of the viscosities of highly concentrated suspensions on solids concentrations and particle size distributions is investigated by using an orifice viscometer. Based on the extensive amount of data on pertinent systems, an empirical equation which correlates the relative viscosities of suspensions (or relative moduli of filled polymeric materials) as a function of solids concentrations and particle size distributions is proposed. The equation has a constant which characterizes size distributions of spherical particles and can be determined experimentally without measuring viscosities. For uniform-size spherical particles, it reduces to the well-known Einstein equation at dilute solids concentrations.

“Assume the Position . . . You Fit the Description”: Psychosocial Experiences and Racial Battle Fatigue Among African American Male College Students

Abstract: The present study examines the experiences of 36 Black male students, in focus group interviews, enrolled at Harvard University; Michigan State University; University of California, Berkeley; University of Illinois; and the University of Michigan. Two themes emerged: (a) anti-Black male stereotyping and marginality (or Black misandry), which caused (b) extreme hypersurveillance and control. Respondents experienced racial microaggressions in three domains: (a) campus—academic, (b) campus—social, and (c) campus—public spaces. Black males are stereotyped and placed under increased surveillance by community and local policing tactics on and off campus. Across these domains, Black males were defined as being “out of place” and “fitting the description” of illegitimate nonmembers of the campus community. Students reported psychological stress responses symptomatic of racial battle fatigue (e.g., frustration, shock, anger, disappointment, resentment, anxiety, helplessness, hopelessness, and fear). There was unan...

The multiscale coarse-graining method. I. A rigorous bridge between atomistic and coarse-grained models.

Abstract: Coarse-grained (CG) models provide a computationally efficient method for rapidly investigating the long time- and length-scale processes that play a critical role in many important biological and soft matter processes Recently, Izvekov and Voth introduced a new multiscale coarse-graining (MS-CG) method [J Phys Chem B 109, 2469 (2005); J Chem Phys 123, 134105 (2005)] for determining the effective interactions between CG sites using information from simulations of atomically detailed models The present work develops a formal statistical mechanical framework for the MS-CG method and demonstrates that the variational principle underlying the method may, in principle, be employed to determine the many-body potential of mean force (PMF) that governs the equilibrium distribution of positions of the CG sites for the MS-CG models A CG model that employs such a PMF as a “potential energy function” will generate an equilibrium probability distribution of CG sites that is consistent with the atomically detailed model from which the PMF is derived Consequently, the MS-CG method provides a formal multiscale bridge rigorously connecting the equilibrium ensembles generated with atomistic and CG models The variational principle also suggests a class of practical algorithms for calculating approximations to this many-body PMF that are optimal These algorithms use computer simulation data from the atomically detailed model Finally, important generalizations of the MS-CG method are introduced for treating systems with rigid intramolecular constraints and for developing CG models whose equilibrium momentum distribution is consistent with that of an atomically detailed model

Considerations in the choice of interobserver reliability estimates

Abstract: Two types of interobserver reliability values may be needed in treatment studies in which observers constitute the primary data-acquisition system: trial reliability and the reliability of the composite unit or score which is subsequently analyzed, e.g., daily or weekly session totals. Two approaches to determining interobserver reliability are described: percentage agreement and "correlational" measures of reliability. The interpretation of these estimates, factors affecting their magnitude, and the advantages and limitations of each approach are presented.