University of Utah

About: University of Utah is a education organization based out in Salt Lake City, Utah, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 52894 authors who have published 124076 publications receiving 5265834 citations. The organization is also known as: The U & The University of Utah.

A genome-wide view of the spectrum of spontaneous mutations in yeast

Abstract: The mutation process ultimately defines the genetic features of all populations and, hence, has a bearing on a wide range of issues involving evolutionary genetics, inheritance, and genetic disorders, including the predisposition to cancer. Nevertheless, formidable technical barriers have constrained our understanding of the rate at which mutations arise and the molecular spectrum of their effects. Here, we report on the use of complete-genome sequencing in the characterization of spontaneously arising mutations in the yeast Saccharomyces cerevisiae. Our results confirm some findings previously obtained by indirect methods but also yield numerous unexpected findings, in particular a very high rate of point mutation and skewed distribution of base-substitution types in the mitochondrion, a very high rate of segmental duplication and deletion in the nuclear genome, and substantial deviations in the mutational profile among various model organisms.

Timing of Elective Repeat Cesarean Delivery at Term and Neonatal Outcomes

Abstract: BACKGROUND Because of increased rates of respiratory complications, elective cesarean delivery is discouraged before 39 weeks of gestation unless there is evidence of fetal lung maturity. We assessed associations between elective cesarean delivery at term (37 weeks of gestation or longer) but before 39 weeks of gestation and neonatal outcomes. METHODS We studied a cohort of consecutive patients undergoing repeat cesarean sections performed at 19 centers of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network from 1999 through 2002. Women with viable singleton pregnancies delivered electively (i.e., before the onset of labor and without any recognized indications for delivery before 39 weeks of gestation) were included. The primary outcome was the composite of neonatal death and any of several adverse events, including respiratory complications, treated hypoglycemia, newborn sepsis, and admission to the neonatal intensive care unit (ICU). RESULTS Of 24,077 repeat cesarean deliveries at term, 13,258 were performed electively; of these, 35.8% were performed before 39 completed weeks of gestation (6.3% at 37 weeks and 29.5% at 38 weeks) and 49.1% at 39 weeks of gestation. One neonatal death occurred. As compared with births at 39 weeks, births at 37 weeks and at 38 weeks were associated with an increased risk of the primary outcome (adjusted odds ratio for births at 37 weeks, 2.1; 95% confidence interval [CI], 1.7 to 2.5; adjusted odds ratio for births at 38 weeks, 1.5; 95% CI, 1.3 to 1.7; P for trend <0.001). The rates of adverse respiratory outcomes, mechanical ventilation, newborn sepsis, hypoglycemia, admission to the neonatal ICU, and hospitalization for 5 days or more were increased by a factor of 1.8 to 4.2 for births at 37 weeks and 1.3 to 2.1 for births at 38 weeks. CONCLUSIONS Elective repeat cesarean delivery before 39 weeks of gestation is common and is associated with respiratory and other adverse neonatal outcomes.

Wave-equation traveltime inversion

Abstract: This paper presents a new traveltime inversion method based on the wave equation. In this new method, designated as wave-equation traveltime inversion (WT), seismograms are computed by any full-wave forward modeling method (we use a finite-difference method). The velocity model is perturbed until the traveltimes from the synthetic seismograms are best fitted to the observed traveltimes in a least squares sense. A gradient optimization method is used and the formula for the Frechet derivative (perturbation of traveltimes with respect to velocity) is derived directly from the wave equation. No traveltime picking or ray tracing is necessary, and there are no high frequency assumptions about the data. Body wave, diffraction, reflection and head wave traveltimes can be incorporated into the inversion. In the high-frequency limit, WT inversion reduces to ray-based traveltime tomography. It can also be shown that WT inversion is approximately equivalent to full-wave inversion when the starting velocity model is 'close' to the actual model.Numerical simulations show that WT inversion succeeds for models with up to 80 percent velocity contrasts compared to the failure of full-wave inversion for some models with no more than 10 percent velocity contrast. We also show that the WT method succeeds in inverting a layered velocity model where a shooting ray-tracing method fails to compute the correct first arrival times. The disadvantage of the WT method is that it appears to provide less model resolution compared to full-wave inversion, but this problem can be remedied by a hybrid traveltime + full-wave inversion method (Luo and Schuster, 1989).

Clarifying adverse drug events: a clinician's guide to terminology, documentation, and reporting

Abstract: Adverse drug events cause substantial morbidity and mortality, yet they remain underappreciated and misunderstood. The terminology to describe errors and patient harm associated with medications causes much confusion. This article uses the case study of a patient with multiple adverse drug events to clarify key terms, such as adverse event, adverse drug reaction, adverse drug event, medication error, and side effect. The case discussion illustrates clinical approaches to analyzing the causal connection between a suspect drug and an adverse event. Examples and rationale for meaningful documentation of adverse drug events are provided, along with an outline of the types of events that should be reported to regulatory agencies.