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Institution

University of Utah

EducationSalt Lake City, Utah, United States
About: University of Utah is a education organization based out in Salt Lake City, Utah, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 52894 authors who have published 124076 publications receiving 5265834 citations. The organization is also known as: The U & The University of Utah.


Papers
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Journal ArticleDOI
TL;DR: These validated prediction rules identified children at very low risk of clinically-important traumatic brain injuries (ciTBI) for whom CT might be unnecessary and missed neurosurgery in validation populations.

1,304 citations

Journal ArticleDOI
02 May 1997-Cell
TL;DR: A convergence of repression pathways for bHLH-Zip proteins and nuclear receptors is established and suggests this type of regulation may be more widely conserved than previously suspected.

1,303 citations

Journal ArticleDOI
26 Feb 2004-Nature
TL;DR: The injection, transport and detection of spin-polarized carriers using an organic semiconductor as the spacer layer in a spin-valve structure is reported, yielding low-temperature giant magnetoresistance effects as large as 40 per cent.
Abstract: A spin valve is a layered structure of magnetic and non-magnetic (spacer) materials whose electrical resistance depends on the spin state of electrons passing through the device and so can be controlled by an external magnetic field. The discoveries of giant magnetoresistance and tunnelling magnetoresistance in metallic spin valves have revolutionized applications such as magnetic recording and memory, and launched the new field of spin electronics--'spintronics'. Intense research efforts are now devoted to extending these spin-dependent effects to semiconductor materials. But while there have been noteworthy advances in spin injection and detection using inorganic semiconductors, spin-valve devices with semiconducting spacers have not yet been demonstrated. pi-conjugated organic semiconductors may offer a promising alternative approach to semiconductor spintronics, by virtue of their relatively strong electron-phonon coupling and large spin coherence. Here we report the injection, transport and detection of spin-polarized carriers using an organic semiconductor as the spacer layer in a spin-valve structure, yielding low-temperature giant magnetoresistance effects as large as 40 per cent.

1,298 citations

Journal ArticleDOI
13 Apr 2007-Science
TL;DR: The genome sequence of an Indian-origin Macaca mulatta female is determined and compared with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families.
Abstract: The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.

1,297 citations

Journal ArticleDOI
TL;DR: Ceritinib was highly active in patients with advanced, ALK-rearranged NSCLC, including those who had had disease progression during crizotinib treatment, regardless of the presence of resistance mutations in ALK.
Abstract: BackgroundNon–small-cell lung cancer (NSCLC) harboring the anaplastic lymphoma kinase gene (ALK) rearrangement is sensitive to the ALK inhibitor crizotinib, but resistance invariably develops. Ceritinib (LDK378) is a new ALK inhibitor that has shown greater antitumor potency than crizotinib in preclinical studies. MethodsIn this phase 1 study, we administered oral ceritinib in doses of 50 to 750 mg once daily to patients with advanced cancers harboring genetic alterations in ALK. In an expansion phase of the study, patients received the maximum tolerated dose. Patients were assessed to determine the safety, pharmacokinetic properties, and antitumor activity of ceritinib. Tumor biopsies were performed before ceritinib treatment to identify resistance mutations in ALK in a group of patients with NSCLC who had had disease progression during treatment with crizotinib. ResultsA total of 59 patients were enrolled in the dose-escalation phase. The maximum tolerated dose of ceritinib was 750 mg once daily; dose-l...

1,297 citations


Authors

Showing all 53431 results

NameH-indexPapersCitations
Bert Vogelstein247757332094
George M. Whitesides2401739269833
Hongjie Dai197570182579
Robert M. Califf1961561167961
Frank E. Speizer193636135891
Yusuke Nakamura1792076160313
David L. Kaplan1771944146082
Marc G. Caron17367499802
George M. Church172900120514
Steven P. Gygi172704129173
Lily Yeh Jan16246773655
Tobin J. Marks1591621111604
David W. Bates1591239116698
Alfred L. Goldberg15647488296
Charles M. Perou156573202951
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023203
2022769
20217,363
20207,015
20196,309
20185,651