University of Utah

About: University of Utah is a education organization based out in Salt Lake City, Utah, United States. It is known for research contribution in the topics: Population & Medicine. The organization has 52894 authors who have published 124076 publications receiving 5265834 citations. The organization is also known as: The U & The University of Utah.

Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

Abstract: Inheritance of a defect in a neuronal mechanism that regulates response to auditory stimuli was studied in nine families with multiple cases of schizophrenia. The defect, a decrease in the normal inhibition of the P50 auditory-evoked response to the second of paired stimuli, is associated with attentional disturbances in schizophrenia. Decreased P50 inhibition occurs not only in most schizophrenics, but also in many of their nonschizophrenic relatives, in a distribution consistent with inherited vulnerability for the illness. Neurobiological investigations in both humans and animal models indicated that decreased function of the α7-nicotinic cholinergic receptor could underlie the physiological defect. In the present study, a genome-wide linkage analysis, assuming autosomal dominant transmission, showed that the defect is linked [maximum logarithm of the odds (lod) score = 5.3 with zero recombination] to a dinucleotide polymorphism at chromosome 15q13-14, the site of the α7-nicotinic receptor. Despite many schizophrenics’ extremely heavy nicotine use, nicotinic receptors were not previously thought to be involved in schizophrenia. The linkage data thus provide unique new evidence that the α7-nicotinic receptor gene may be responsible for the inheritance of a pathophysiological aspect of the illness.

Driven to Distraction: Dual-Task Studies of Simulated Driving and Conversing on a Cellular Telephone

Abstract: Dual-task studies assessed the effects of cellular-phone conversations on performance of a simulated driving task. Perfor- mance was not disrupted by listening to radio broadcasts or listening to a book on tape. Nor was it disrupted by a continuous shadowing task using a handheld phone, ruling out, in this case, dual-task inter- pretations associated with holding the phone, listening, or speaking. However, significant interference was observed in a word-generation variant of the shadowing task, and this deficit increased with the diffi- culty of driving. Moreover, unconstrained conversations using either a handheld or a hands-free cell phone resulted in a twofold increase in the failure to detect simulated traffic signals and slower reactions to those signals that were detected. We suggest that cellular-phone use disrupts performance by diverting attention to an engaging cognitive context other than the one immediately associated with driving. crease in the likelihood of getting into an accident, and that this increased risk was comparable to that found for driving with a blood alcohol level above the legal limit. In addition, these authors found no reliable safety advantages for those individuals who used a hands-free cellular device. The authors concluded that the interference associated with cell-phone use was due to attentional factors rather than to pe- ripheral factors such as holding the phone. The field studies of Redelmeier and Tibshirani (1997) establish a correlation between cell-phone use and motor-vehicle accidents, but they do not necessarily imply that use of cell phones causes an increase in accident rates. There may be self-selection factors creating an asso- ciation between cell-phone use and accidents. For example, people who drive and use their cell phone may be more likely to engage in risky behavior, and this increase in risk taking may underlie the corre- lation. Similarly, being in a highly emotional state may increase one's likelihood of driving erratically and may also increase one's likelihood of talking on the cell phone. In order to assess the possible causal rela- tionship between cell-phone use and automobile accidents, carefully controlled experiments, such as the ones described in this report, are needed.

Behavioral Competence among Mothers of Infants in the First Year: The Mediational Role of Maternal Self‐Efficacy

Abstract: This study tests the idea that mothers' self-efficacy beliefs mediate the effects on parenting behavior of variables such as depression, perceptions of infant temperamental difficulty, and social-marital supports. Subjects were 48 clinically depressed and 38 nondepressed mothers observed in interaction with their 3-13-month-old infants (M = 7.35 months). As predicted, maternal self-efficacy beliefs related significantly to maternal behavioral competence independent of the effects of other variables. When the effects of self-efficacy were controlled, parenting competence no longer related significantly to social-marital supports or maternal depression. In addition, maternal self-efficacy correlated significantly with perceptions of infant difficulty after controlling for family demographic variables. These results suggest that maternal self-efficacy mediates relations between maternal competence and other psychosocial variables and may play a crucial role in determining parenting behavior and infant psychosocial risk.