Institution
University of Utah
Education•Salt Lake City, Utah, United States•
About: University of Utah is a education organization based out in Salt Lake City, Utah, United States. It is known for research contribution in the topics: Population & Medicine. The organization has 52894 authors who have published 124076 publications receiving 5265834 citations. The organization is also known as: The U & The University of Utah.
Topics: Population, Medicine, Poison control, Health care, Cancer
Papers published on a yearly basis
Papers
More filters
••
University of Toronto1, Yale University2, Saarland University3, University of Utah4, Oregon Health & Science University5, University of Lyon6, University of Pennsylvania7, Georgia Regents University8, National Institutes of Health9, Harvard University10, Washington University in St. Louis11, Western General Hospital12, University of Bari13, Mayo Clinic14, Johns Hopkins University15, University Health Network16
TL;DR: The goal of this international HHT guidelines process was to develop evidence-informed consensus guidelines regarding the diagnosis of HHT and the prevention of H HT-related complications and treatment of symptomatic disease.
Abstract: Background HHT is an autosomal dominant disease with an estimated prevalence of at least 1/5000 which can frequently be complicated by the presence of clinically significant arteriovenous malformations in the brain, lung, gastrointestinal tract and liver. HHT is under-diagnosed and families may be unaware of the available screening and treatment, leading to unnecessary stroke and life-threatening hemorrhage in children and adults.
Objective The goal of this international HHT guidelines process was to develop evidence-informed consensus guidelines regarding the diagnosis of HHT and the prevention of HHT-related complications and treatment of symptomatic disease.
Methods The overall guidelines process was developed using the AGREE framework, using a systematic search strategy and literature retrieval with incorporation of expert evidence in a structured consensus process where published literature was lacking. The Guidelines Working Group included experts (clinical and genetic) from eleven countries, in all aspects of HHT, guidelines methodologists, health care workers, health care administrators, HHT clinic staff, medical trainees, patient advocacy representatives and patients with HHT. The Working Group determined clinically relevant questions during the pre-conference process. The literature search was conducted using the OVID MEDLINE database, from 1966 to October 2006. The Working Group subsequently convened at the Guidelines Conference to partake in a structured consensus process using the evidence tables generated from the systematic searches.
Results The outcome of the conference was the generation of 33 recommendations for the diagnosis and management of HHT, with at least 80% agreement amongst the expert panel for 30 of the 33 recommendations.
890 citations
••
TL;DR: This study attempts to comprehensively and objectively measure subjective qualities of the urban street environment using ratings from an expert panel to arm researchers with operational definitions they can use to measure the street environment and test for significant associations with walking behaviour.
Abstract: This study attempts to comprehensively and objectively measure subjective qualities of the urban street environment. Using ratings from an expert panel, it was possible to measure five urban design qualities in terms of physical characteristics of streets and their edges: imageability, enclosure, human scale, transparency and complexity. The operational definitions do not always comport with the qualitative definitions, and provide new insights into the nature of these urban design qualities. The immediate purpose of this study is to arm researchers with operational definitions they can use to measure the street environment and test for significant associations with walking behaviour. A validation study is currently underway in New York City. Depending on the outcome of this and other follow-up research, the ultimate purpose would be to inform urban design practice.
890 citations
••
Max Planck Society1, Leibniz Institute for Neurobiology2, Monash University, Clayton campus3, University of Montpellier4, Open University5, Thermo Electron6, German Criminal Police Office7, University of Würzburg8, University of Victoria9, University of Gothenburg10, Royal Canadian Mounted Police11, University of Tasmania12, University of Houston13, University of Mainz14, Paul Scherrer Institute15, Carnegie Institution for Science16, University of Kiel17, University of Greifswald18, University of Edinburgh19, Oregon State University20, Heidelberg University21, Utrecht University22, National Institute of Polar Research23, University of Utah24, Freiberg University of Mining and Technology25, United States Geological Survey26, Chinese Academy of Sciences27, University of Pavia28, University of Tübingen29, University of Lausanne30, Los Alamos National Laboratory31, University of Melbourne32
TL;DR: In this paper, the authors present new analytical data of major and trace elements for the geological MPI-DING glasses KL2-G, ML3B-G and ATHO-G.
Abstract: We present new analytical data of major and trace elements for the geological MPI-DING glasses KL2-G, ML3B-G, StHs6/80-G, GOR128-G, GOR132-G, BM90/21-G, T1-G, and ATHO-G. Different analytical methods were used to obtain a large spectrum of major and trace element data, in particular, EPMA, SIMS, LA-ICPMS, and isotope dilution by TIMS and ICPMS. Altogether, more than 60 qualified geochemical laboratories worldwide contributed to the analyses, allowing us to present new reference and information values and their uncertainties (at 95% confidence level) for up to 74 elements. We complied with the recommendations for the certification of geological reference materials by the International Association of Geoanalysts (IAG). The reference values were derived from the results of 16 independent techniques, including definitive (isotope dilution) and comparative bulk (e.g., INAA, ICPMS, SSMS) and microanalytical (e.g., LA-ICPMS, SIMS, EPMA) methods. Agreement between two or more independent methods and the use of definitive methods provided traceability to the fullest extent possible. We also present new and recently published data for the isotopic compositions of H, B, Li, O, Ca, Sr, Nd, Hf, and Pb. The results were mainly obtained by high-precision bulk techniques, such as TIMS and MC-ICPMS. In addition, LA-ICPMS and SIMS isotope data of B, Li, and Pb are presented.
889 citations
••
TL;DR: The human cDNA and genomic characterization of a new homeobox gene, RIEG, causing Rieger syndrome is reported, providing opportunities for understanding ocular, dental and umbilical development and the pleiotropic interactions of pituitary and limb morphogenesis.
Abstract: Rieger syndrome (REG) is an autosomal–dominant human disorder that includes anomalies of the anterior chamber of the eye, dental hypoplasia and a protuberant umbilicus. We report the human cDNA and genomic characterization of a new homeobox gene, RIEG, causing this disorder. Six mutations in RIEG were found in individuals with the disorder. The cDNA sequence of Rieg, the murine homologue of RIEG, has also been isolated and shows strong homology with the human sequence. In mouse embryos Rieg mRNA localized in the periocular mesenchyme, maxillary and mandibular epithelia, and umbilicus, all consistent with RIEG abnormalities. The gene is also expressed in Rathke's pouch, vitelline vessels and the limb mesenchyme. RIEG characterization provides opportunities for understanding ocular, dental and umbilical development and the pleiotropic interactions of pituitary and limb morphogenesis.
888 citations
••
TL;DR: The previously unrecognized contribution of the lateral retinaculum as a restraint to lateral patellar translation may shed new light on the failures of isolated lateral release for acute lateral dislocation of the patella.
Abstract: The purpose of this investigation was to identify and quantify the soft tissue restraints, both medially and laterally, to lateral patellar translation. These restraints to lateral patellar translation at 20° of knee flexion were tested biomechanically on a universal testing instrument in nine fresh-frozen cadaveric knees. After preconditioning the tissues, the patella of each intact knee was translated laterally to a distance at which a force of 200 N was recorded. This distance was used to translate the patella for the remaining structures to be sectioned. The contribution of each structure to the total restraining force was determined as the percent of the force to restrain the intact specimen by sectioning the restraints in a predetermined order. The contribution of each structure to the restraining force was defined as the difference between the restraining force before and after its sectioning. The medial patellofemoral ligament was found to be the primary restraint to lateral patellar translation a...
886 citations
Authors
Showing all 53431 results
Name | H-index | Papers | Citations |
---|---|---|---|
Bert Vogelstein | 247 | 757 | 332094 |
George M. Whitesides | 240 | 1739 | 269833 |
Hongjie Dai | 197 | 570 | 182579 |
Robert M. Califf | 196 | 1561 | 167961 |
Frank E. Speizer | 193 | 636 | 135891 |
Yusuke Nakamura | 179 | 2076 | 160313 |
David L. Kaplan | 177 | 1944 | 146082 |
Marc G. Caron | 173 | 674 | 99802 |
George M. Church | 172 | 900 | 120514 |
Steven P. Gygi | 172 | 704 | 129173 |
Lily Yeh Jan | 162 | 467 | 73655 |
Tobin J. Marks | 159 | 1621 | 111604 |
David W. Bates | 159 | 1239 | 116698 |
Alfred L. Goldberg | 156 | 474 | 88296 |
Charles M. Perou | 156 | 573 | 202951 |