Showing papers by "University of Valencia published in 2009"

Common variants conferring risk of schizophrenia

Abstract: Schizophrenia is a complex disorder, caused by both genetic and environmental factors and their interactions. Research on pathogenesis has traditionally focused on neurotransmitter systems in the brain, particularly those involving dopamine. Schizophrenia has been considered a separate disease for over a century, but in the absence of clear biological markers, diagnosis has historically been based on signs and symptoms. A fundamental message emerging from genome-wide association studies of copy number variations (CNVs) associated with the disease is that its genetic basis does not necessarily conform to classical nosological disease boundaries. Certain CNVs confer not only high relative risk of schizophrenia but also of other psychiatric disorders. The structural variations associated with schizophrenia can involve several genes and the phenotypic syndromes, or the 'genomic disorders', have not yet been characterized. Single nucleotide polymorphism (SNP)-based genome-wide association studies with the potential to implicate individual genes in complex diseases may reveal underlying biological pathways. Here we combined SNP data from several large genome-wide scans and followed up the most significant association signals. We found significant association with several markers spanning the major histocompatibility complex (MHC) region on chromosome 6p21.3-22.1, a marker located upstream of the neurogranin gene (NRGN) on 11q24.2 and a marker in intron four of transcription factor 4 (TCF4) on 18q21.2. Our findings implicating the MHC region are consistent with an immune component to schizophrenia risk, whereas the association with NRGN and TCF4 points to perturbation of pathways involved in brain development, memory and cognition.

Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document.

Abstract: Abbreviations ACE: angiotensin-converting enzyme; BP: blood pressure; DBP: diastolic blood pressure; eGFR: estimated glomerular filtration rate; ESC: European Society of Cardiology; ESH: European Society of Hypertension; ET: endothelin; IMT: carotid intima-media thickness; JNC: Joint National Commit

Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics.

Abstract: Metaplastic breast cancers (MBC) are aggressive, chemoresistant tumors characterized by lineage plasticity. To advance understanding of their pathogenesis and relatedness to other breast cancer subtypes, 28 MBCs were compared with common breast cancers using comparative genomic hybridization, transcriptional profiling, and reverse-phase protein arrays and by sequencing for common breast cancer mutations. MBCs showed unique DNA copy number aberrations compared with common breast cancers. PIK3CA mutations were detected in 9 of 19 MBCs (47.4%) versus 80 of 232 hormone receptor-positive cancers (34.5%; P = 0.32), 17 of 75 HER-2-positive samples (22.7%; P = 0.04), 20 of 240 basal-like cancers (8.3%; P < 0.0001), and 0 of 14 claudin-low tumors (P = 0.004). Of 7 phosphatidylinositol 3-kinase/AKT pathway phosphorylation sites, 6 were more highly phosphorylated in MBCs than in other breast tumor subtypes. The majority of MBCs displayed mRNA profiles different from those of the most common, including basal-like cancers. By transcriptional profiling, MBCs and the recently identified claudin-low breast cancer subset constitute related receptor-negative subgroups characterized by low expression of GATA3-regulated genes and of genes responsible for cell-cell adhesion with enrichment for markers linked to stem cell function and epithelial-to-mesenchymal transition (EMT). In contrast to other breast cancers, claudin-low tumors and most MBCs showed a significant similarity to a "tumorigenic" signature defined using CD44(+)/CD24(-) breast tumor-initiating stem cell-like cells. MBCs and claudin-low tumors are thus enriched in EMT and stem cell-like features, and may arise from an earlier, more chemoresistant breast epithelial precursor than basal-like or luminal cancers. PIK3CA mutations, EMT, and stem cell-like characteristics likely contribute to the poor outcomes of MBC and suggest novel therapeutic targets.

Local Metamaterial-Based Waveguides in Gaps Between Parallel Metal Plates

Abstract: This letter presents a new metamaterial-based waveguide technology referred to as ridge gap waveguides. The main advantages of the ridge gap waveguides compared to hollow waveguides are that they are planar and much cheaper to manufacture, in particular at high frequencies such as for millimeter and sub- millimeter waves. The latter is due to the fact that there are no mechanical joints across which electric currents must float. The gap waveguides have lower losses than microstrip lines, and they are completely shielded by metal so no additional packaging is needed, in contrast to the severe packaging problems associated with microstrip circuits. The gap waveguides are realized in a narrow gap between two parallel metal plates by using a texture or multilayer structure on one of the surfaces. The waves follow metal ridges in the textured surface. All wave propagation in other directions is prohibited (in cutoff) by realizing a high surface impedance (ideally a perfect magnetic conductor) in the textured surface at both sides of all ridges. Thereby, cavity resonances do not appear either within the band of operation. The present letter introduces the gap waveguide and presents some initial simulated results.

Management of high blood pressure in children and adolescents: recommendations of the European Society of Hypertension

Abstract: Hypertension in children and adolescents has gained ground in cardiovascular medicine, thanks to the progress made in several areas of pathophysiological and clinical research. These guidelines represent a consensus among specialists involved in the detection and control of high blood pressure in children and adolescents. The guidelines synthesize a considerable amount of scientific data and clinical experience and represent best clinical wisdom upon which physicians, nurses and families should base their decisions. They call attention to the burden of hypertension in children and adolescents, and its contribution to the current epidemic of cardiovascular disease, these guidelines should encourage public policy makers, to develop a global effort to improve identification and treatment of high blood pressure among children and adolescents.

Horizontal visibility graphs: Exact results for random time series

Abstract: networks. This procedure allows us to apply methods of complex network theory for characterizing time series. In this work we present the horizontal visibility algorithm, a geometrically simpler and analytically solvable version of our former algorithm, focusing on the mapping of random series series of independent identically distributed random variables. After presenting some properties of the algorithm, we present exact results on the topological properties of graphs associated with random series, namely, the degree distribution, the clustering coefficient, and the mean path length. We show that the horizontal visibility algorithm stands as a simple method to discriminate randomness in time series since any random series maps to a graph with an exponential degree distribution of the shape Pk=1 /32 /3 k2 , independent of the probability distribution from which the series was generated. Accordingly, visibility graphs with other Pk are related to nonrandom series. Numerical simulations confirm the accuracy of the theorems for finite series. In a second part, we show that the method is able to distinguish chaotic series from independent and identically distributed i.i.d. theory, studying the following situations: i noise-free low-dimensional chaotic series, ii low-dimensional noisy chaotic series, even in the presence of large amounts of noise, and iii high-dimensional chaotic series coupled map lattice, without needs for additional techniques such as surrogate data or noise reduction methods. Finally, heuristic arguments are given to explain the topological properties of chaotic series, and several sequences that are conjectured to be random are analyzed.

Chapter 2. Fasciola, lymnaeids and human fascioliasis, with a global overview on disease transmission, epidemiology, evolutionary genetics, molecular epidemiology and control.

Abstract: Fascioliasis, caused by liver fluke species of the genus Fasciola, has always been well recognized because of its high veterinary impact but it has been among the most neglected diseases for decades with regard to human infection. However, the increasing importance of human fascioliasis worldwide has re‐launched interest in fascioliasis. From the 1990s, many new concepts have been developed regarding human fascioliasis and these have furnished a new baseline for the human disease that is very different to a simple extrapolation from fascioliasis in livestock. Studies have shown that human fascioliasis presents marked heterogeneity, including different epidemiological situations and transmission patterns in different endemic areas. This heterogeneity, added to the present emergence/re‐emergence of the disease both in humans and animals in many regions, confirms a worrying global scenario. The huge negative impact of fascioliasis on human communities demands rapid action. When analyzing how better to define control measures for endemic areas differing at such a level, it would be useful to have genetic markers that could distinguish each type of transmission pattern and epidemiological situation. Accordingly, this chapter covers aspects of aetiology, geographical distribution, epidemiology, transmission and control in order to obtain a solid baseline for the interpretation of future results. The origins and geographical spread of F. hepatica and F. gigantica in both the ruminant pre‐domestication times and the livestock post‐domestication period are analyzed. Paleontological, archaeological and historical records, as well as genetic data on recent dispersal of livestock species, are taken into account to establish an evolutionary framework for the two fasciolids across all continents. Emphasis is given to the distributional overlap of both species and the roles of transportation, transhumance and trade in the different overlap situations. Areas with only one Fasciola spp. are distinguished from local and zonal overlaps in areas where both fasciolids co‐exist. Genetic techniques applied to liver flukes in recent years that are useful to elucidate the genetic characteristics of the two fasciolids are reviewed. The intra‐specific and inter‐specific variabilities of ‘pure’ F. hepatica and ‘pure’ F. gigantica were ascertained by means of complete sequences of ribosomal deoxyribonucleic acid (rDNA) internal transcribed spacer (ITS)‐2 and ITS‐1 and mitochondrial deoxyribonucleic acid (mtDNA) cox1 and nad1 from areas with only one fasciolid species. Fasciolid sequences of the same markers scattered in the literature are reviewed. The definitive haplotypes established appear to fit the proposed global evolutionary scenario. Problems posed by fasciolid cross‐breeding, introgression and hybridization in overlap areas are analyzed. Nuclear rDNA appears to correlate with adult fluke characteristics and fasciolid/lymnaeid specificity, whereas mtDNA does not. However, flukes sometimes appear so intermediate that they cannot be ascribed to either F. hepatica‐like or F. gigantica‐like forms and snail specificity may be opposite to the one deduced from the adult morphotype. The phenotypic characteristics of adults and eggs of ‘pure’ F. hepatica and F. gigantica, as well as of intermediate forms in overlap areas, are compared, with emphasis on the definitive host influence on egg size in humans. Knowledge is sufficient to support F. hepatica and F. gigantica as two valid species, which recently diverged by adaptation to different pecoran and lymnaeid hosts in areas with differing environmental characteristics. Their phenotypic differences and ancient pre‐domestication origins involve a broad geographical area that largely exceeds the typical, more local scenarios known for sub‐species units. Phenomena such as abnormal ploidy and aspermic parthenogenesis in hybrids suggest that their separate evolution in pre‐domestication times allowed them to achieve almost total genetic isolation. Recent sequencing results suggest that present assumptions on fasciolid‐lymnaeid specificity might be wrong. The crucial role of lymnaeids in fascioliasis transmission, epidemiology and control was the reason for launching a worldwide lymnaeid molecular characterization initiative. This initiative has already furnished useful results on several continents. A standardized methodology for fasciolids and lymnaeids is proposed herein in order that future work is undertaken on a comparable basis. A complete understanding of molecular epidemiology is expected to help greatly in designing global actions and local interventions for control of fascioliasis.

MOJAVE: Monitoring of Jets in Active Galactic Nuclei with VLBA Experiments. VI. Kinematics Analysis of a Complete Sample of Blazar Jets

Abstract: We discuss the jet kinematics of a complete flux-density-limited sample of 135 radio-loud active galactic nuclei (AGNs) resulting from a 13 year program to investigate the structure and evolution of parsec-scale jet phenomena. Our analysis is based on new 2 cm Very Long Baseline Array (VLBA) images obtained between 2002 and 2007, but includes our previously published observations made at the same wavelength, and is supplemented by VLBA archive data. In all, we have used 2424 images spanning the years 1994-2007 to study and determine the motions of 526 separate jet features in 127 jets. The data quality and temporal coverage (a median of 15 epochs per source) of this complete AGN jet sample represent a significant advance over previous kinematics surveys. In all but five AGNs, the jets appear one-sided, most likely the result of differential Doppler boosting. In general, the observed motions are directed along the jet ridge line, outward from the optically thick core feature. We directly observe changes in speed and/or direction in one third of the well-sampled jet components in our survey. While there is some spread in the apparent speeds of separate features within an individual jet, the dispersion is about three times smaller than the overall dispersion of speeds among all jets. This supports the idea that there is a characteristic flow that describes each jet, which we have characterized by the fastest observed component speed. The observed maximum speed distribution is peaked at ~10c, with a tail that extends out to ~50c. This requires a distribution of intrinsic Lorentz factors in the parent population that range up to ~50. We also note the presence of some rare low-pattern speeds or even stationary features in otherwise rapidly flowing jets that may be the result of standing re-collimation shocks, and/or a complex geometry and highly favorable Doppler factor.

Quantifying the heart of darkness with GHALO – a multibillion particle simulation of a galactic halo

Abstract: We perform a series of simulations of a Galactic mass dark matter halo at different resolutions: our largest uses over 3 billion particles and has a mass resolution of 1000 M⊙. We quantify the structural properties of the inner dark matter distribution and study how they depend on numerical resolution. We can measure the density profile to a distance of 120 pc (0.05 per cent of Rvir), where the logarithmic slope is −0.8 and −1.4 at (0.5 per cent of Rvir). We propose a new two-parameter fitting function that has a linearly varying logarithmic density gradient over the resolved radii which fits the GHALO and VL2 density profiles extremely well. Convergence in the halo shape is achieved at roughly three times the convergence radius for the density profile at which point the halo becomes more spherical due to numerical resolution. The six-dimensional phase-space profile is dominated by the presence of the substructures and does not follow a power law, except in the central few kpc which is devoid of substructure even at this resolution. The quantity, ρ/σ3, which is often used as a proxy for the six-dimensional phase-space density should be used with caution.

Revision of the Single-Channel Algorithm for Land Surface Temperature Retrieval From Landsat Thermal-Infrared Data

Abstract: This paper presents a revision, an update, and an extension of the generalized single-channel (SC) algorithm developed by Jimenez-Munoz and Sobrino (2003), which was particularized to the thermal-infrared (TIR) channel (band 6) located in the Landsat-5 Thematic Mapper (TM) sensor. The SC algorithm relies on the concept of atmospheric functions (AFs) which are dependent on atmospheric transmissivity and upwelling and downwelling atmospheric radiances. These AFs are fitted versus the atmospheric water vapor content for operational purposes. In this paper, we present updated fits using MODTRAN 4 radiative transfer code, and we also extend the application of the SC algorithm to the TIR channel of the TM sensor onboard the Landsat-4 platform and the enhanced TM plus sensor onboard the Landsat-7 platform. Five different atmospheric sounding databases have been considered to create simulated data used for retrieving AFs and to test the algorithm. The test from independent simulated data provided root mean square error (rmse) values below 1 K in most cases when atmospheric water vapor content is lower than 2 g middotcm-2. For values higher than 3 g middotcm-2, errors are not acceptable, as what occurs with other SC algorithms. Results were also tested using a land surface temperature map obtained from one Landsat-5 image acquired over an agricultural area using inversion of the radiative transfer equation and the atmospheric profile measured in situ at the sensor overpass time. The comparison with this ldquoground-truthrdquo map provided an rmse of 1.5 K.

Mononuclear Lanthanide Single Molecule Magnets Based on the Polyoxometalates [Ln(W5O18)2]9− and [Ln(β2-SiW11O39)2]13−(LnIII = Tb, Dy, Ho, Er, Tm, and Yb)

Abstract: The first two families of polyoxometalate-based single-molecule magnets (SMMs) are reported here. Compounds of the general formula [Ln(W5O18)2]9− (LnIII = Tb, Dy, Ho, and Er) and [Ln(SiW11O39)2]13− (LnIII = Tb, Dy, Ho, Er, Tm, and Yb) have been magnetically characterized with static and dynamic measurements. Slow relaxation of the magnetization, typically associated with SMM-like behavior, was observed for [Ln(W5O18)2]9− (LnIII = Ho and Er) and [Ln(SiW11O39)2]13− (LnIII = Dy, Ho, Er, and Yb). Among them, only the [Er(W5O18)2]9− derivative exhibited such a behavior above 2 K with an energy barrier for the reversal of the magnetization of 55 K. For a deep understanding of the appearance of slow relaxation of the magnetization in these types of mononuclear complexes, the ligand-field parameters and the splitting of the J ground-state multiplet of the lanthanide ions have been also estimated.

Bidirectional chemo-switching of spin state in a microporous framework.

Abstract: The ins and outs of spin: Using the microporous coordination polymer {Fe(pz)[Pt(CN)(4)]} (1, pz=pyrazine), incorporating spin-crossover subunits, two-directional magnetic chemo-switching is achieved at room temperature. In situ magnetic measurements following guest vapor injection show that most guest molecules transform 1 from the low-spin (LS) state to the high-spin (HS) state, whereas CS(2) uniquely causes the reverse HS-to-LS transition.

AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer

Abstract: Dysregulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway occurs frequently in human cancer. PTEN tumor suppressor or PIK3CA oncogene mutations both direct PI3K-dependent tumorigenesis largely through activation of the AKT/PKB kinase. However, here we show through phosphoprotein profiling and functional genomic studies that many PIK3CA mutant cancer cell lines and human breast tumors exhibit only minimal AKT activation and a diminished reliance on AKT for anchorage-independent growth. Instead, these cells retain robust PDK1 activation and membrane localization and exhibit dependency on the PDK1 substrate SGK3. SGK3 undergoes PI3K- and PDK1-dependent activation in PIK3CA mutant cancer cells. Thus, PI3K may promote cancer through both AKT-dependent and AKT-independent mechanisms. Knowledge of differential PI3K/PDK1 signaling could inform rational therapeutics in cancers harboring PIK3CA mutations.

Understanding the mechanism of polar Diels–Alder reactions

Abstract: A good correlation between the activation energy and the polar character of Diels–Alder reactions measured as the charge transfer at the transition state structure has been found. This electronic parameter controls the reaction rate to an even greater extent than other recognized structural features. The proposed polar mechanism, which is characterized by the electrophilic/nucleophilic interactions at the transition state structure, can be easily predicted by analyzing the electrophilicity/nucleophilicity indices defined within the conceptual density functional theory. Due to the significance of the polarity of the reaction, Diels–Alder reactions should be classified as non-polar (N), polar (P), and ionic (I).

Preterm resuscitation with low oxygen causes less oxidative stress, inflammation, and chronic lung disease.

Abstract: OBJECTIVE The goal was to reduce adverse pulmonary adverse outcomes, oxidative stress, and inflammation in neonates of 24 to 28 weeks of gestation initially resuscitated with fractions of inspired oxygen of 30% or 90%. METHODS Randomized assignment to receive 30% (N = 37) or 90% (N = 41) oxygen was performed. Targeted oxygen saturation values were 75% at 5 minutes and 85% at 10 minutes. Blood oxidized glutathione (GSSG)/reduced glutathione ratio and urinary o-tyrosine, 8-oxo-dihydroxyguanosine, and isoprostane levels, isofuran elimination, and plasma interleukin 8 and tumor necrosis factor alpha levels were determined. RESULTS The low-oxygen group needed fewer days of oxygen supplementation (6 vs 22 days; P < .01) and fewer days of mechanical ventilation (13 vs 27 days; P < .01) and had a lower incidence of bronchopulmonary dysplasia at discharge (15.4% vs 31.7%; P < .05). GSSG/reduced glutathione x 100 ratios at day 1 and 3 were significantly higher in the high-oxygen group (day 1: high-oxygen group: 13.36 +/- 5.25; low-oxygen group: 8.46 +/- 3.87; P < .01; day 3: high-oxygen group: 8.87 +/- 4.40; low-oxygen group: 6.97 +/- 3.11; P < .05). Urinary markers of oxidative stress were increased significantly in the high-oxygen group, compared with the low-oxygen group, in the first week after birth. GSSG levels on day 3 and urinary isofuran, o-tyrosine, and 8-hydroxy-2'-deoxyguanosine levels on day 7 were correlated significantly with development of chronic lung disease. CONCLUSIONS Resuscitation of preterm neonates with 30% oxygen causes less oxidative stress, inflammation, need for oxygen, and risk of bronchopulmonary dysplasia.

The Heliospheric Imagers Onboard the STEREO Mission

Abstract: Mounted on the sides of two widely separated spacecraft, the two Heliospheric Imager (HI) instruments onboard NASA’s STEREO mission view, for the first time, the space between the Sun and Earth. These instruments are wide-angle visible-light imagers that incorporate sufficient baffling to eliminate scattered light to the extent that the passage of solar coronal mass ejections (CMEs) through the heliosphere can be detected. Each HI instrument comprises two cameras, HI-1 and HI-2, which have 20° and 70° fields of view and are off-pointed from the Sun direction by 14.0° and 53.7°, respectively, with their optical axes aligned in the ecliptic plane. This arrangement provides coverage over solar elongation angles from 4.0° to 88.7° at the viewpoints of the two spacecraft, thereby allowing the observation of Earth-directed CMEs along the Sun – Earth line to the vicinity of the Earth and beyond. Given the two separated platforms, this also presents the first opportunity to view the structure and evolution of CMEs in three dimensions. The STEREO spacecraft were launched from Cape Canaveral Air Force Base in late October 2006, and the HI instruments have been performing scientific observations since early 2007. The design, development, manufacture, and calibration of these unique instruments are reviewed in this paper. Mission operations, including the initial commissioning phase and the science operations phase, are described. Data processing and analysis procedures are briefly discussed, and ground-test results and in-orbit observations are used to demonstrate that the performance of the instruments meets the original scientific requirements.

Yukawa Alignment in the Two-Higgs-Doublet Model

Abstract: In multi-Higgs-doublet models the alignment in flavor space of the relevant Yukawa matrices guarantees the absence of tree-level flavor-changing couplings of the neutral scalar fields. We analyze the consequences of this condition within the two-Higgs-doublet model and show that it leads to a generic Yukawa structure which contains as particular cases all known specific implementations of the model based on ${\mathcal{Z}}_{2}$ symmetries. All possible freedom in the Yukawa sector gets parametrized in terms of three complex couplings ${\ensuremath{\varsigma}}_{f}$. In spite of having flavor conservation in the neutral scalar couplings, the phases of these three parameters represent potential new sources of $CP$ violation.

Prevalence of corneal astigmatism before cataract surgery.

Abstract: Purpose To analyze the prevalence and presentation patterns of corneal astigmatism in cataract surgery candidates. Setting University of Valencia, Valencia, Spain. Methods Refractive and keratometric values were measured before surgery in patients having cataract extraction. Descriptive statistics of refractive and keratometric cylinder data were analyzed and correlated by age ranges. Results Refractive and keratometric data from 4540 eyes of 2415 patients (mean age 60.59 years ± 9.87 [SD]; range 32 to 87 years) differed significantly when the patients were divided into 10-year subsets. There was a trend toward less negative corneal astigmatism values, except the steepest corneal radius and the J 45 vector component, in older groups (Kruskal-Wallis, P Conclusions Corneal astigmatism less than 1.25 D was present in most cataract surgery candidates; it was higher in about 22%, with slight differences between the various age ranges. This information is useful for intraocular lens (IOL) manufacturers to evaluate which age ranges concentrate the parameters most frequently needed in sphere and cylinder powers and for surgeons to evaluate which IOLs provide the most effective power range.

Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells

Abstract: Epigenetic mechanisms that maintain neurogenesis throughout adult life remain poorly understood. Trithorax group (trxG) and Polycomb group (PcG) gene products are part of an evolutionarily conserved chromatin remodelling system that activate or silence gene expression, respectively. Although PcG member Bmi1 has been shown to be required for postnatal neural stem cell self-renewal, the role of trxG genes remains unknown. Here we show that the trxG member Mll1 (mixed-lineage leukaemia 1) is required for neurogenesis in the mouse postnatal brain. Mll1-deficient subventricular zone neural stem cells survive, proliferate and efficiently differentiate into glial lineages; however, neuronal differentiation is severely impaired. In Mll1-deficient cells, early proneural Mash1 (also known as Ascl1) and gliogenic Olig2 expression are preserved, but Dlx2, a key downstream regulator of subventricular zone neurogenesis, is not expressed. Overexpression of Dlx2 can rescue neurogenesis in Mll1-deficient cells. Chromatin immunoprecipitation demonstrates that Dlx2 is a direct target of MLL in subventricular zone cells. In differentiating wild-type subventricular zone cells, Mash1, Olig2 and Dlx2 loci have high levels of histone 3 trimethylated at lysine 4 (H3K4me3), consistent with their transcription. In contrast, in Mll1-deficient subventricular zone cells, chromatin at Dlx2 is bivalently marked by both H3K4me3 and histone 3 trimethylated at lysine 27 (H3K27me3), and the Dlx2 gene fails to properly activate. These data support a model in which Mll1 is required to resolve key silenced bivalent loci in postnatal neural precursors to the actively transcribed state for the induction of neurogenesis, but not for gliogenesis.

Slow dynamics of the magnetization in one-dimensional coordination polymers: single-chain magnets.

Abstract: Slow relaxation of the magnetization (i.e., "magnet-like" behavior) in materials composed of magnetically isolated chains was observed for the first time in 2001. This type of behavior was predicted in the 1960s by Glauber in a chain of ferromagnetically coupled Ising spins (the so-called Glauber dynamics). In 2002, this new class of nanomagnets was named single-chain magnets (SCMs) by analogy to single-molecule magnets that are isolated molecules displaying related superparamagnetic properties. A long-range order occurs only at T = 0 K in any pure one-dimensional (1D) system, and thus such systems remain in their paramagnetic state at any finite temperature. Nevertheless, the combined action of large uniaxial anisotropy and intrachain magnetic interactions between high-spin magnetic units of the 1D arrangement promotes long relaxation times for the magnetization reversal with decreasing temperature, and finally at significantly low temperatures, the material can behave as a magnet. In this Forum Article, we summarize simple theoretical approaches used for understanding typical SCM behavior and some rational synthetic strategies to obtain SCM materials together with representative examples of SCMs previously reported.

High Diversity of the Viral Community from an Antarctic Lake

Abstract: Viruses are the most abundant biological entities and can control microbial communities, but their identity in terrestrial and freshwater Antarctic ecosystems is unknown. The genetic structure of an Antarctic lake viral community revealed unexpected genetic richness distributed across the highest number of viral families that have been found to date in aquatic viral metagenomes. In contrast to other known aquatic viromes, which are dominated by bacteriophage sequences, this Antarctic virus assemblage had a large proportion of sequences related to eukaryotic viruses, including phycodnaviruses and single-stranded DNA (ssDNA) viruses not previously identified in aquatic environments. We also observed that the transition from an ice-covered lake in spring to an open-water lake in summer led to a change from a ssDNA- to a double-stranded DNA-virus-dominated assemblage, possibly reflecting a seasonal shift in host organisms.