Institution
University of Valencia
Education•Valencia, Spain•
About: University of Valencia is a education organization based out in Valencia, Spain. It is known for research contribution in the topics: Population & Neutrino. The organization has 27096 authors who have published 65669 publications receiving 1765689 citations. The organization is also known as: Universitat de València & UV.
Topics: Population, Neutrino, European union, Higgs boson, Lepton
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TL;DR: A role for HMA5 is proposed in Cu compartmentalization and detoxification and a regulatory role for the plant-specific domain of the CCH Cu chaperone is suggested.
Abstract: *† ‡ § Summary Since copper (Cu) is essential in key physiological oxidation reactions, organisms have developed strategies for handling Cu while avoiding its potentially toxic effects. Among the tools that have evolved to cope with Cu is a network of Cu homeostasis factors such as Cu-transporting P-type ATPases that play a key role in transmembrane Cu transport. In this work we present the functional characterization of an Arabidopsis Cutransporting P-type ATPase, denoted heavy metal ATPase 5 (HMA5), and its interaction with Arabidopsis metallochaperones. HMA5 is primarily expressed in roots, and is strongly and specifically induced by Cu in whole plants. We have identified and characterized plants carrying two independent T-DNA insertion alleles, hma5-1 and hma5-2. Both mutants are hypersensitive to Cu but not to other metals such as iron, zinc or cadmium. Interestingly, root tips from Cu-treated hma5 mutants exhibit a wave-like phenotype at early stages and later on main root growth completely arrests whereas lateral roots emerge near the crown. Accordingly, these lines accumulate Cu in roots to a greater extent than wild-type plants under Cu excess. Finally, yeast two-hybrid experiments demonstrate that the metal-binding domains of HMA5 interact with Arabidopsis ATX1-like Cu chaperones, and suggest a regulatory role for the plant-specific domain of the CCH Cu chaperone. Based on these findings, we propose a role for HMA5 in Cu compartmentalization and detoxification.
283 citations
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TL;DR: Ecotoxicological risk assessment through RQs showed that organophosphorus and azol presented high risk for algae; organoph phosphorus, benzimidazoles, carbamates, juvenile hormone mimic and other pesticides for daphnia, and organphosphorus, azol and juvenile hormone mimics for fish.
283 citations
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TL;DR: Treatment with certain antioxidants, such as sulphur-containing antioxidants, vitamins C and E or the Ginkgo biloba extract EGb 761, protects against the age-associated oxidative damage to mtDNA and oxidation of mitochondrial glutathione and prevents changes in mitochondrial morphology and function associated with aging of the brain and liver.
Abstract: In the eighties, Miquel and Fleming suggested that mitochondria play a key role in cellular aging. Mitochondria, and specially mitochondrial DNA (mtDNA), are major targets of free radical attack. At present, it is well established that mitochondrial deficits accumulate upon aging due to oxidative damage. Thus, oxidative lesions to mtDNA accumulate with age in human and rodent tissues. Furthermore, levels of oxidative damage to mtDNA are several times higher than those of nuclear DNA. Mitochondrial size increases whereas mitochondrial membrane potential decreases with age in brain and liver.Recently, we have shown that treatment with certain antioxidants, such as sulphur-containing antioxidants, vitamins C and E or the Ginkgo biloba extract EGb 761, protects against the age-associated oxidative damage to mtDNA and oxidation of mitochondrial glutathione. Moreover, the extract EGb 761 also prevents changes in mitochondrial morphology and function associated with aging of the brain and liver. Thus, mitochondr...
282 citations
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TL;DR: In this paper, a split-window equation is derived by linearization of Planck's function and atmospheric trasmittance, which depends on atmospheric water vapor, viewing angle, and channel surface emissivities.
282 citations
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TL;DR: In this article, the authors compared the efficiency, productivity and differences in technology of different European and US banking systems for the year 1992, using a non-parametric approach together with the Malmquist index.
282 citations
Authors
Showing all 27402 results
Name | H-index | Papers | Citations |
---|---|---|---|
H. S. Chen | 179 | 2401 | 178529 |
Alvaro Pascual-Leone | 165 | 969 | 98251 |
Sabino Matarrese | 155 | 775 | 123278 |
Subir Sarkar | 149 | 1542 | 144614 |
Carlos Escobar | 148 | 1184 | 95346 |
Marco Costa | 146 | 1458 | 105096 |
Carmen García | 139 | 1503 | 96925 |
Javier Cuevas | 138 | 1689 | 103604 |
M. I. Martínez | 134 | 1251 | 79885 |
Marco Aurelio Diaz | 134 | 1015 | 93580 |
Avelino Corma | 134 | 1049 | 89095 |
Kevin Lannon | 133 | 1652 | 95436 |
Marina Cobal | 132 | 1078 | 85437 |
Mogens Dam | 131 | 1109 | 83717 |
Marcel Vos | 131 | 993 | 85194 |