Institution
University of Valencia
Education•Valencia, Spain•
About: University of Valencia is a education organization based out in Valencia, Spain. It is known for research contribution in the topics: Population & Neutrino. The organization has 27096 authors who have published 65669 publications receiving 1765689 citations. The organization is also known as: Universitat de València & UV.
Topics: Population, Neutrino, European union, Higgs boson, Lepton
Papers published on a yearly basis
Papers
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TL;DR: This critical review examines the design of enclosed, primarily bicyclic cryptands as hosts for anions, with a small scattering of higher polyhedra when deemed appropriate to the discussion.
Abstract: The design of supramolecular hosts for anions began with simple diaza bicycles, named katapinands, and has evolved over the last 40 years to a number of elegantly designed receptors capable of binding many different anions. About the same time the term cryptand appeared in reference to another bicyclic compound that was selective for alkaline-earth ions. Since the first report these simple bicycles, a vast arena of hosts has appeared, including acyclic, monocyclic, and other multicyclic supramolecular receptors. Studies of these systems have revealed considerable information about anion coordination chemistry, including the fact that many of these complexes mimic their transition-metal corollaries in terms of coordination numbers. However, for anions interactions occur via H-bonding most often, rather than the coordinate covalent or dative bonds observed in transition-metal coordination. This critical review examines the design of enclosed, primarily bicyclic cryptands as hosts for anions, with a small scattering of higher polyhedra when deemed appropriate to the discussion. In order to show the development (evolution) of the field, key examples of early work will be noted and compared with more recent developments (136 references).
271 citations
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Boston Children's Hospital1, Istituto Giannina Gaslini2, Shaare Zedek Medical Center3, Utrecht University4, University of California, San Diego5, Great Ormond Street Hospital for Children NHS Foundation Trust6, University College London7, Hacettepe University8, Radboud University Nijmegen9, University of Valencia10, University of Liège11, University of Paris12, Istanbul University13, University of Lausanne14, University of Hasselt15, Yokohama City University16, Autonomous University of Barcelona17, Semmelweis University18, Tel Aviv University19, University of Brescia20, Novartis21
TL;DR: In this trial, canakinumab was effective in controlling and preventing flares in patients with colchicine‐resistant familial Mediterranean fever, mevalonate kinase deficiency, and TRAPS.
Abstract: Background Familial Mediterranean fever, mevalonate kinase deficiency (also known as the hyperimmunoglobulinemia D syndrome), and the tumor necrosis factor receptor–associated periodic syn...
271 citations
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TL;DR: The proposed BSS-based approach is able to obtain a unified AA signal by exploiting the atrial information present in every ECG lead, which results in an increased robustness with respect to electrode selection and placement.
Abstract: This contribution addresses the extraction of atrial activity (AA) from real electrocardiogram (ECG) recordings of atrial fibrillation (AF). We show the appropriateness of independent component analysis (ICA) to tackle this biomedical challenge when regarded as a blind source separation (BSS) problem. ICA is a statistical tool able to reconstruct the unobservable independent sources of bioelectric activity which generate, through instantaneous linear mixing, a measurable set of signals. The three key hypothesis that make ICA applicable in the present scenario are discussed and validated: 1) AA and ventricular activity (VA) are generated by sources of independent bioelectric activity; 2) AA and VA present non-Gaussian distributions; and 3) the generation of the surface ECG potentials from the cardioelectric sources can be regarded as a narrow-band linear propagation process. To empirically endorse these claims, an ICA algorithm is applied to recordings from seven patients with persistent AF. We demonstrate that the AA source can be identified using a kurtosis-based reordering of the separated signals followed by spectral analysis of the sub-Gaussian sources. In contrast to traditional methods, the proposed BSS-based approach is able to obtain a unified AA signal by exploiting the atrial information present in every ECG lead, which results in an increased robustness with respect to electrode selection and placement.
270 citations
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TL;DR: The components of an e-tongue (automatic sampler, array of chemical sensors, and data processing system) and their most important applications in food analysis in this new century are described.
270 citations
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TL;DR: These findings point to a molecular mechanism in humans by which higher triglycerides and CRP can be coupled with lower plasma glucose concentrations and position GCKR in central pathways regulating both hepatic triglyceride and glucose metabolism.
Abstract: OBJECTIVE Using the genome-wide-association approach, we recently identified the glucokinase regulatory protein gene ( GCKR , rs780094) region as a novel quantitative trait locus for plasma triglyceride concentration in Europeans. Here, we sought to study the association of GCKR variants with metabolic phenotypes including measures of glucose homeostasis, to evaluate the GCKR locus in samples of non-European ancestry, and to fine-map across the associated genomic interval. RESEARCH DESIGN AND METHODS We performed association studies in 12 independent cohorts comprising a total of >45,000 individuals representing several ancestral groups (whites from Northern and Southern Europe, whites from the United States, African Americans from the United States, Hispanics of Caribbean origin, and Chinese, Malays and Asian Indians from Singapore). We conducted genetic fine-mapping across the ∼417 kilobase region of linkage disequilibrium spanning GCKR and 16 other genes on chromosome 2p23 by imputing untyped HapMap SNPs and genotyping 104 SNPs across the associated genomic interval.. RESULTS We provide comprehensive evidence that GCKR rs780094 is associated with opposite effects on fasting plasma triglyceride (p meta =3x10 -56 ) and glucose (p meta =1x10 -13 ) concentrations. In addition, we confirmed recent reports that the same SNP is associated with C-reative protein level (p=5x10 -5 ). Both fine mapping approaches revealed a common missense GCKR variant (rs1260326, Pro446Leu, 34% frequency, r 2 =0.93 with rs780094) as the strongest association signal in the region. CONCLUSIONS- These findings point to a molecular mechanism in humans by which higher triglycerides and C-reactive protein can be coupled with lower plasma glucose concentrations and position GCKR in central pathways regulating both hepatic triglyceride and glucose metabolism.
270 citations
Authors
Showing all 27402 results
Name | H-index | Papers | Citations |
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H. S. Chen | 179 | 2401 | 178529 |
Alvaro Pascual-Leone | 165 | 969 | 98251 |
Sabino Matarrese | 155 | 775 | 123278 |
Subir Sarkar | 149 | 1542 | 144614 |
Carlos Escobar | 148 | 1184 | 95346 |
Marco Costa | 146 | 1458 | 105096 |
Carmen García | 139 | 1503 | 96925 |
Javier Cuevas | 138 | 1689 | 103604 |
M. I. Martínez | 134 | 1251 | 79885 |
Marco Aurelio Diaz | 134 | 1015 | 93580 |
Avelino Corma | 134 | 1049 | 89095 |
Kevin Lannon | 133 | 1652 | 95436 |
Marina Cobal | 132 | 1078 | 85437 |
Mogens Dam | 131 | 1109 | 83717 |
Marcel Vos | 131 | 993 | 85194 |