Institution
University of Valencia
Education•Valencia, Spain•
About: University of Valencia is a education organization based out in Valencia, Spain. It is known for research contribution in the topics: Population & Neutrino. The organization has 27096 authors who have published 65669 publications receiving 1765689 citations. The organization is also known as: Universitat de València & UV.
Topics: Population, Neutrino, European union, Higgs boson, Lepton
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the authors measured the effect of jet suppression in heavy ion collisions at the LHC and provided a direct sensitivity to the physics of jet quenching, using a sample of lead-lead collisions at root S-NN = 2.76 TeV.
239 citations
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TL;DR: The heterogeneity of the rat liver mitochondrial population, from a structural, metabolic and functional and functional (active and non-active mitochondrial population dispersion) point of view could thus be demonstrated by flow-cytometry analysis.
Abstract: Washed and purified rat- or mouse-liver mitochondria exhibiting high membrane integrity and metabolic activity were studied by flow cytometry. The electrophoretic accumulation/redistribution of cationic lipophilic probes, rhodamine 123, safranine O and a cyanine derivative, 3,3'-dihexyloxadicarbocyanine iodide, during the energization process was studied and was consistent with the generation of a negative internal membrane potential. An exception to this was nonylacridine orange which spontaneously bound to the mitochondrial membrane by hydrophobic interactions via its hydrocarbon chain. Energized purified mitochondria stained with potentiometric dyes exhibited both higher fluorescence and population homogeneity than the non-energized or deenergized (nigericin plus valinomycin) mitochondria. By contrast, under non-energized or deenergized conditions, the mitochondrial population exhibited fluorescence intensity heterogeneity related to the residual membrane potential; two subpopulations were evident, one of low fluorescence which may be related to the autofluorescence of the mitochondria (plus non-specific dye binding) and a second population which exhibited high fluorescence. Flow cytometry of the unpurified, simply washed, rat-liver mitochondria stained with rhodamine 123, a classically used dye, provided evidence of their heterogeneity in terms of light-scattering properties and membrane-potential-related fluorescence. One third of the washed mitochondria were found to be non-functional by such assays. The fluorescence of purified rat-liver mitochondria due to the membrane potential built up by endogenous substrates indicates heterogeneity of the mitochondrial population with respect to levels of endogenous substrates. The low-angle light scattering increases upon energization and provides some original information about the shape and modification of the inner mitochondrial conformation accompanying the energization. The heterogeneity of the rat liver mitochondrial population, from a structural, metabolic (existence of endogenous substrates) and functional (active and non-active mitochondrial population dispersion) point of view could thus be demonstrated by flow-cytometry analysis. Two animal models were examined with regard to the alteration of the mitochondrial membrane potential under the effects of drugs (rat-liver mitochondria), and the effects of ammonium toxicity (mouse-liver mitochondria). These results are promising and open new perspectives in the study of mitochondriopathies.
238 citations
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Carleton University1, University of Tennessee2, University of Notre Dame3, University of Milan4, Joint Institute for Nuclear Research5, Peking University6, Aix-Marseille University7, Academia Sinica8, University of Paris-Sud9, Tsinghua University10, Argonne National Laboratory11, University of Science and Technology of China12, Zhejiang University13, Humboldt University of Berlin14, Chinese Academy of Sciences15, University of Hawaii at Manoa16, University of Valencia17, University of Victoria18, University of Barcelona19, Oak Ridge National Laboratory20, University of Savoy21, Wuhan University22, Nankai University23, Central China Normal University24, China Center of Advanced Science and Technology25, Shandong University26, National University of Defense Technology27
TL;DR: In this article, the authors provide detailed discussion on important topics in tau-charm physics that will be explored during the next few years at \bes3. Both theoretical and experimental issues are covered, including extensive reviews of recent theoretical developments and experimental techniques.
Abstract: This physics book provides detailed discussions on important topics in $\tau$-charm physics that will be explored during the next few years at \bes3 . Both theoretical and experimental issues are covered, including extensive reviews of recent theoretical developments and experimental techniques. Among the subjects covered are: innovations in Partial Wave Analysis (PWA), theoretical and experimental techniques for Dalitz-plot analyses, analysis tools to extract absolute branching fractions and measurements of decay constants, form factors, and CP-violation and \DzDzb-oscillation parameters. Programs of QCD studies and near-threshold tau-lepton physics measurements are also discussed.
238 citations
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TL;DR: The efficacy of a treatment for claustrophobia using only Virtual Reality (VR) exposure was examined and the necessity of a theoretical framework for this new medium for exposure therapy is discussed.
238 citations
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TL;DR: Clinicians can use the proposed classification algorithm for differentiating neuropathic, nociceptive, and central sensitization pain for each individual patient with chronic pain.
Abstract: Background: The awareness is growing that central sensitization is of prime importance for the assessment and management of chronic pain, but its classification is challenging clinically since no gold standard method of assessment exists.
Objectives: Designing the first set of classification criteria for the classification of central sensitization pain.
Methods: A body of evidence from original research papers was used by 18 pain experts from 7 different countries to design the first classification criteria for central sensitization pain.
Results: It is proposed that the classification of central sensitization pain entails 2 major steps: the exclusion of neuropathic pain and the differential classification of nociceptive versus central sensitization pain. For the former, the International Association for the Study of Pain diagnostic criteria are available for diagnosing or excluding neuropathic pain. For the latter, clinicians are advised to screen their patients for 3 major classification criteria, and use them to complete the classification algorithm for each individual patient with chronic pain. The first and obligatory criterion entails disproportionate pain, implying that the severity of pain and related reported or perceived disability are disproportionate to the nature and extent of injury or pathology (i.e., tissue damage or structural impairments). The 2 remaining criteria are 1) the presence of diffuse pain distribution, allodynia, and hyperalgesia; and 2) hypersensitivity of senses unrelated to the musculoskeletal system (defined as a score of at least 40 on the Central Sensitization Inventory).
Limitations: Although based on direct and indirect research findings, the classification algorithm requires experimental testing in future studies.
Conclusion: Clinicians can use the proposed classification algorithm for differentiating neuropathic, nociceptive, and central sensitization pain.
Key words: Chronic pain, diagnosis, hypersensitivity, classification, neuropathic pain
238 citations
Authors
Showing all 27402 results
Name | H-index | Papers | Citations |
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H. S. Chen | 179 | 2401 | 178529 |
Alvaro Pascual-Leone | 165 | 969 | 98251 |
Sabino Matarrese | 155 | 775 | 123278 |
Subir Sarkar | 149 | 1542 | 144614 |
Carlos Escobar | 148 | 1184 | 95346 |
Marco Costa | 146 | 1458 | 105096 |
Carmen García | 139 | 1503 | 96925 |
Javier Cuevas | 138 | 1689 | 103604 |
M. I. Martínez | 134 | 1251 | 79885 |
Marco Aurelio Diaz | 134 | 1015 | 93580 |
Avelino Corma | 134 | 1049 | 89095 |
Kevin Lannon | 133 | 1652 | 95436 |
Marina Cobal | 132 | 1078 | 85437 |
Mogens Dam | 131 | 1109 | 83717 |
Marcel Vos | 131 | 993 | 85194 |