Institution
University of Valencia
Education•Valencia, Spain•
About: University of Valencia is a education organization based out in Valencia, Spain. It is known for research contribution in the topics: Population & Neutrino. The organization has 27096 authors who have published 65669 publications receiving 1765689 citations. The organization is also known as: Universitat de València & UV.
Topics: Population, Neutrino, European union, Higgs boson, Lepton
Papers published on a yearly basis
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Nicholas J Kassebaum1, Ryan M Barber1, Zulfiqar A Bhutta2, Zulfiqar A Bhutta3 +613 more•Institutions (272)
TL;DR: In this article, the authors quantified maternal mortality throughout the world by underlying cause and age from 1990 to 2015 for ages 10-54 years by systematically compiling and processing all available data sources from 186 of 195 countries and territories.
641 citations
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TL;DR: It is demonstrated here the importance of morphogenetic conversions in C. albicans pathogenesis, and an engineered strain in which this developmental transition can be externally modulated both in vitro and in vivo is constructed.
Abstract: It is widely assumed that the ability of Candida albicans to switch between different morphologies is required for pathogenesis. However, most virulence studies have used mutants that are permanently locked into either the yeast or filamentous forms which are avirulent but unsuitable for discerning the role of morphogenetic conversions at the various stages of the infectious process. We have constructed a strain in which this developmental transition can be externally modulated both in vitro and in vivo. This was achieved by placing one copy of the NRG1 gene (a negative regulator of filamentation) under the control of a tetracycline-regulatable promoter. This modified strain was then tested in an animal model of hematogenously disseminated candidiasis. Mice injected with this strain under conditions permitting hyphal development succumbed to the infection, whereas all of the animals injected under conditions that inhibited this transition survived. Importantly, fungal burdens were almost identical in both sets of animals, indicating that, whereas filament formation appears to be required for the mortality resulting from a deep-seated infection, yeast cells play an important role early in the infectious process by extravasating and disseminating to the target organs. Moreover, these infecting Candida yeast cells still retained their pathogenic potential, as demonstrated by allowing this developmental transition to occur at various time points postinfection. We demonstrate here the importance of morphogenetic conversions in C. albicans pathogenesis. This engineered strain should provide a useful tool in unraveling the individual contributions of the yeast and filamentous forms at various stages of the infectious process.
638 citations
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TL;DR: The algorithm described here, called OptQuest/NLP or OQNLP, is a heuristic designed to find global optima for pure and mixed integer nonlinear problems with many constraints and variables, where all problem functions are differentiable with respect to the continuous variables.
Abstract: The algorithm described here, called OptQuest/NLP or OQNLP, is a heuristic designed to find global optima for pure and mixed integer nonlinear problems with many constraints and variables, where all problem functions are differentiable with respect to the continuous variables. It uses OptQuest, a commercial implementation of scatter search developed by OptTek Systems, Inc., to provide starting points for any gradient-based local solver for nonlinear programming (NLP) problems. This solver seeks a local solution from a subset of these points, holding discrete variables fixed. The procedure is motivated by our desire to combine the superior accuracy and feasibility-seeking behavior of gradient-based local NLP solvers with the global optimization abilities of OptQuest. Computational results include 155 smooth NLP and mixed integer nonlinear program (MINLP) problems due to Floudas et al. (1999), most with both linear and nonlinear constraints, coded in the GAMS modeling language. Some are quite large for global optimization, with over 100 variables and 100 constraints. Global solutions to almost all problems are found in a small number of local solver calls, often one or two.
631 citations
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TL;DR: It is indicated that risk variants for psychiatric disorders aggregate in particular biological pathways and that these pathways are frequently shared between disorders.
Abstract: Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple genetic associations with such disorders, but better methods are needed to derive the underlying biological mechanisms that these signals indicate. We sought to identify biological pathways in GWAS data from over 60,000 participants from the Psychiatric Genomics Consortium. We developed an analysis framework to rank pathways that requires only summary statistics. We combined this score across disorders to find common pathways across three adult psychiatric disorders: schizophrenia, major depression and bipolar disorder. Histone methylation processes showed the strongest association, and we also found statistically significant evidence for associations with multiple immune and neuronal signaling pathways and with the postsynaptic density. Our study indicates that risk variants for psychiatric disorders aggregate in particular biological pathways and that these pathways are frequently shared between disorders. Our results confirm known mechanisms and suggest several novel insights into the etiology of psychiatric disorders.
630 citations
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TL;DR: In this article, the authors used the ATLAS detector to detect dijet asymmetry in the collisions of lead ions at the Large Hadron Collider and found that the transverse energies of dijets in opposite hemispheres become systematically more unbalanced with increasing event centrality, leading to a large number of events which contain highly asymmetric di jets.
Abstract: By using the ATLAS detector, observations have been made of a centrality-dependent dijet asymmetry in the collisions of lead ions at the Large Hadron Collider. In a sample of lead-lead events with a per-nucleon center of mass energy of 2.76 TeV, selected with a minimum bias trigger, jets are reconstructed in fine-grained, longitudinally segmented electromagnetic and hadronic calorimeters. The transverse energies of dijets in opposite hemispheres are observed to become systematically more unbalanced with increasing event centrality leading to a large number of events which contain highly asymmetric dijets. This is the first observation of an enhancement of events with such large dijet asymmetries, not observed in proton-proton collisions, which may point to an interpretation in terms of strong jet energy loss in a hot, dense medium.
630 citations
Authors
Showing all 27402 results
Name | H-index | Papers | Citations |
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H. S. Chen | 179 | 2401 | 178529 |
Alvaro Pascual-Leone | 165 | 969 | 98251 |
Sabino Matarrese | 155 | 775 | 123278 |
Subir Sarkar | 149 | 1542 | 144614 |
Carlos Escobar | 148 | 1184 | 95346 |
Marco Costa | 146 | 1458 | 105096 |
Carmen García | 139 | 1503 | 96925 |
Javier Cuevas | 138 | 1689 | 103604 |
M. I. Martínez | 134 | 1251 | 79885 |
Marco Aurelio Diaz | 134 | 1015 | 93580 |
Avelino Corma | 134 | 1049 | 89095 |
Kevin Lannon | 133 | 1652 | 95436 |
Marina Cobal | 132 | 1078 | 85437 |
Mogens Dam | 131 | 1109 | 83717 |
Marcel Vos | 131 | 993 | 85194 |