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Institution

University of Valencia

EducationValencia, Spain
About: University of Valencia is a education organization based out in Valencia, Spain. It is known for research contribution in the topics: Population & Neutrino. The organization has 27096 authors who have published 65669 publications receiving 1765689 citations. The organization is also known as: Universitat de València & UV.


Papers
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Journal ArticleDOI
Haidong Wang1, Timothy M. Wolock1, Austin Carter1, Grant Nguyen1  +497 moreInstitutions (214)
TL;DR: This report provides national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015.

522 citations

Journal ArticleDOI
TL;DR: This is the first comprehensive estimation of how economic resources are lost to headache in Europe, and it is hoped that this will help clarify the financial costs of headaches in Europe.
Abstract: Background and purpose: Headache disorders are very common, but their monetary costs in Europe are unknown. We performed the first comprehensive estimation of how economic resources are lost to headache in Europe. Methods: From November 2008 to August 2009, a cross-sectional survey was conducted in eight countries representing 55% of the adult EU population. Participation rates varied between 11% and 59%. In total, 8412 questionnaires contributed to this analysis. Using bottom-up methodology, we estimated direct (medications, outpatient health care, hospitalization and investigations) and indirect (work absenteeism and reduced productivity at work) annual per-person costs. Prevalence data, simultaneously collected and, for migraine, also derived from a systematic review, were used to impute national costs. Results: Mean per-person annual costs were €1222 for migraine (95% CI 1055–1389; indirect costs 93%), €303 for tension-type headache (TTH, 95% CI 230–376; indirect costs 92%), €3561 for medication-overuse headache (MOH, 95% CI 2487–4635; indirect costs 92%), and €253 for other headaches (95% CI 99–407; indirect costs 82%). In the EU, the total annual cost of headache amongst adults aged 18–65 years was calculated, according to our prevalence estimates, at €173 billion, apportioned to migraine (€111 billion; 64%), TTH (€21 billion; 12%), MOH (€37 billion; 21%) and other headaches (€3 billion; 2%). Using the 15% systematic review prevalence of migraine, calculated costs were somewhat lower (migraine €50 billion, all headache €112 billion annually). Conclusions: Headache disorders are prominent health-related drivers of immense economic losses for the EU. This has immediate implications for healthcare policy. Health care for headache can be both improved and cost saving.

521 citations

Journal ArticleDOI
TL;DR: Data from ten European countries show a striking increase and unusual seasonal pattern of norovirus gastroenteritis in 2002 that occurred concurrently with the emergence of a novel genetic variant, raising questions about the biological properties of the variant and the mechanisms for its rapid dissemination.

521 citations

Journal ArticleDOI
TL;DR: The issue of bioavailability of resveratrol is of paramount importance and is determined by its rapid elimination and the fact that its absorption is highly effective, but the first hepatic step leaves little free resver atrol.
Abstract: Plants containing resveratrol have been used effectively in traditional medicine for over 2000 years. It can be found in some plants, fruits, and derivatives, such as red wine. Therefore, it can be administered by either consuming these natural products or intaking nutraceutical pills. Resveratrol exhibits a wide range of beneficial properties, and this may be due to its molecular structure, which endow resveratrol with the ability to bind to many biomolecules. Among these properties its activity as an anticancer agent, a platelet antiaggregation agent, and an antioxidant, as well as its antiaging, antifrailty, anti-inflammatory, antiallergenic, and so forth activities, is worth highlighting. These beneficial biological properties have been extensively studied in humans and animal models, both in vitro and in vivo. The issue of bioavailability of resveratrol is of paramount importance and is determined by its rapid elimination and the fact that its absorption is highly effective, but the first hepatic step leaves little free resveratrol. Clarifying aspects like stability and pharmacokinetics of resveratrol metabolites would be fundamental to understand and apply the therapeutic properties of resveratrol.

519 citations

Journal ArticleDOI
TL;DR: Oxygen radical antioxidant capacity and trolox equivalent antioxidant capacity (TEAC) assays were compared to estimate the total antioxidant capacity of orange juice, milk, and an orange juice-milk beverage as discussed by the authors.

518 citations


Authors

Showing all 27402 results

NameH-indexPapersCitations
H. S. Chen1792401178529
Alvaro Pascual-Leone16596998251
Sabino Matarrese155775123278
Subir Sarkar1491542144614
Carlos Escobar148118495346
Marco Costa1461458105096
Carmen García139150396925
Javier Cuevas1381689103604
M. I. Martínez134125179885
Marco Aurelio Diaz134101593580
Avelino Corma134104989095
Kevin Lannon133165295436
Marina Cobal132107885437
Mogens Dam131110983717
Marcel Vos13199385194
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20251
2023140
2022487
20214,747
20204,696
20193,996