University of Vermont

About: University of Vermont is a education organization based out in Burlington, Vermont, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 17592 authors who have published 38251 publications receiving 1609874 citations. The organization is also known as: UVM & University of Vermont and State Agricultural College.

The treatment of injuries of the anterior cruciate ligament.

Abstract: The treatment of injuries of the anterior cruciate ligament. R Johnson;B Beynnon;C Nichols;P Renstrom; The Journal of Bone & Joint Surgery

Human health impacts of ecosystem alteration

Abstract: Human activity is rapidly transforming most of Earth’s natural systems How this transformation is impacting human health, whose health is at greatest risk, and the magnitude of the associated disease burden are relatively new subjects within the field of environmental health We discuss what is known about the human health implications of changes in the structure and function of natural systems and propose that these changes are affecting human health in a variety of important waysWe identify several gaps and limitations in the research that has been done to date and propose a more systematic and comprehensive approach to applied research in this field Such efforts could lead to a more robust understanding of the human health impacts of accelerating environmental change and inform decision making in the land-use planning, environmental conservation, and public health policy realms global change | ecosystem services | ecology | planetary boundaries | ecological footprint

Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow

Abstract: Blood flow into the brain is dynamically regulated to satisfy the changing metabolic requirements of neurons, but how this is accomplished has remained unclear. Here we demonstrate a central role for capillary endothelial cells in sensing neural activity and communicating it to upstream arterioles in the form of an electrical vasodilatory signal. We further demonstrate that this signal is initiated by extracellular K+ -a byproduct of neural activity-which activates capillary endothelial cell inward-rectifier K+ (KIR2.1) channels to produce a rapidly propagating retrograde hyperpolarization that causes upstream arteriolar dilation, increasing blood flow into the capillary bed. Our results establish brain capillaries as an active sensory web that converts changes in external K+ into rapid, 'inside-out' electrical signaling to direct blood flow to active brain regions.