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Institution

University of Vermont

EducationBurlington, Vermont, United States
About: University of Vermont is a education organization based out in Burlington, Vermont, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 17592 authors who have published 38251 publications receiving 1609874 citations. The organization is also known as: UVM & University of Vermont and State Agricultural College.


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Journal Article
TL;DR: The data suggest that adults with Eisenmenger syndrome have a more favorable hemodynamic profile and prognosis than adults with primary pulmonary hypertension.
Abstract: BACKGROUND: To date, lung or heart-lung transplantation remains the only definitive treatment for most adults with severe primary pulmonary hypertension or Eisenmenger syndrome Although the hemodynamic derangements and clinical history of adults with severe primary pulmonary hypertension have been well documented, those of adults with Eisenmenger syndrome have not METHODS: We evaluated hemodynamics and nontransplantation survival of 100 adults with severe pulmonary hypertension (34 +/- 9 years, 73 women and 27 men; 57 with primary pulmonary hypertension, 37 with Eisenmenger syndrome, and six with a previously repaired congenital heart defect) followed up by the lung transplant or adult congenital heart services at Washington University RESULTS: Despite a trend toward greater pulmonary artery pressures (107 +/- 20 versus 97 +/- 21 mm Hg, p = 006), patients with Eisenmenger syndrome had greater systemic cardiac indexes (27 +/- 06 versus 22 +/- 08 L/min/m2, p < 005) and lower mean right atrial pressures (5 +/- 2 versus 12 +/- 5 mm Hg, p < 00001) than patients with primary pulmonary hypertension Four (11%) patients with Eisenmenger syndrome died and eight (22%) received transplants during the follow-up interval; 13 (23%) patients with primary pulmonary hypertension died, and 31 (54%) received transplants over the same interval Actuarial survival of patients who did not receive transplants was 97% at 1 year, 89% at 2 years, and 77% at 3 years for patients with Eisenmenger syndrome and 77%, 69%, and 35%, respectively, for patients with primary pulmonary hypertension Data on hemodynamics from a small number of patients with a previously repaired heart defect and severe pulmonary hypertension were similar to those from patients with primary pulmonary hypertension CONCLUSIONS: Our data suggest that adults with Eisenmenger syndrome have a more favorable hemodynamic profile and prognosis than adults with primary pulmonary hypertension

429 citations

Journal ArticleDOI
TL;DR: The safety and activity of ibrutinib in elderly, previously untreated patients with symptomatic chronic lymphocytic leukaemia, or smallymphocytic lymphoma is encouraging, and merits further investigation in phase 3 trials.
Abstract: Summary Background Chemoimmunotherapy has led to improved numbers of patients achieving disease response, and longer overall survival in young patients with chronic lymphocytic leukaemia; however, its application in elderly patients has been restricted by substantial myelosuppression and infection. We aimed to assess safety and activity of ibrutinib, an orally administered covalent inhibitor of Bruton tyrosine kinase (BTK), in treatment-naive patients aged 65 years and older with chronic lymphocytic leukaemia. Methods In our open-label phase 1b/2 trial, we enrolled previously untreated patients at clinical sites in the USA. Eligible patients were aged at least 65 years, and had symptomatic chronic lymphocytic leukaemia or small lymphocytic lymphoma requiring therapy. Patients received 28 day cycles of once-daily ibrutinib 420 mg or ibrutinib 840 mg. The 840 mg dose was discontinued after enrolment had begun because comparable activity of the doses has been shown. The primary endpoint was the safety of the dose-fixed regimen in terms of frequency and severity of adverse events for all patients who received treatment. This study is registered with ClinicalTrials.gov, number NCT01105247. Findings Between May 20, 2010, and Dec 18, 2012, we enrolled 29 patients with chronic lymphocytic leukaemia and two patients with small lymphocytic lymphoma. Median age was 71 years (range 65–84), and 23 (74%) patients were at least 70 years old. Toxicity was mainly of mild-to-moderate severity (grade 1–2). 21 (68%) patients had diarrhoea (grade 1 in 14 [45%] patients, grade 2 in three [10%] patients, and grade 3 in four [13%] patients). 15 (48%) patients developed nausea (grade 1 in 12 [39%] patients and grade 2 in three [10%] patients). Ten (32%) patients developed fatigue (grade 1 in five [16%] patients, grade 2 in four [13%] patients, and grade 3 in one [3%] patient). Three (10%) patients developed grade 3 infections, although no grade 4 or 5 infections occurred. One patient developed grade 3 neutropenia, and one developed grade 4 thrombocytopenia. After a median follow-up of 22·1 months (IQR 18·4–23·2), 22 (71%) of 31 patients achieved an objective response (95% CI 52·0–85·8); four patients (13%) had a complete response, one patient (3%) had a nodular partial response, and 17 (55%) patients had a partial response. Interpretation The safety and activity of ibrutinib in elderly, previously untreated patients with symptomatic chronic lymphocytic leukaemia, or small lymphocytic lymphoma is encouraging, and merits further investigation in phase 3 trials. Funding Pharmacyclics, Leukemia and Lymphoma Society, D Warren Brown Foundation, Mr and Mrs Michael Thomas, Harry Mangurian Foundation, P50 CA140158 to Prof J C Byrd MD.

429 citations

Journal ArticleDOI
30 Dec 2010-Archaea
TL;DR: The methanogens identified in the rumens of cattle and sheep, as well as a number of methane mitigation strategies that have been effective in vivo are described.
Abstract: Methanogens are the only known microorganisms capable of methane production, making them of interest when investigating methane abatement strategies. A number of experiments have been conducted to study the methanogen population in the rumen of cattle and sheep, as well as the relationship that methanogens have with other microorganisms. The rumen methanogen species differ depending on diet and geographical location of the host, as does methanogenesis, which can be reduced by modifying dietary composition, or by supplementation of monensin, lipids, organic acids, or plant compounds within the diet. Other methane abatement strategies that have been investigated are defaunation and vaccines. These mitigation methods target the methanogen population of the rumen directly or indirectly, resulting in varying degrees of efficacy. This paper describes the methanogens identified in the rumens of cattle and sheep, as well as a number of methane mitigation strategies that have been effective in vivo.

428 citations

Journal ArticleDOI
TL;DR: In this article, the authors investigated interactions between cognitive appraisals of, and coping with, stressful life events and their relationship with psychological symptomatology, and found that the "goodness of fit" between appraisal of the controllability of events and the use of problem-and emotion-focused coping was assessed for major life events.
Abstract: The present study investigated interactions between cognitive appraisals of, and coping with, stressful life events and their relationship with psychological symptomatology. Specifically, the “goodness of fit” between appraisals of the controllability of events and the use of problem- and emotion-focused coping was assessed for major life events and daily hassles. In relation to major life events, symptomatology was high when there was a poor fit between appraisals and coping (e.g., trying to change a stressor that was appraised as uncontrollable) and low when there was a good fit between appraisals and coping (e.g., palliating one's emotions when a stressor was perceived as uncontrollable). No effects were found in relation to daily hassles. Results were generally consistent with cognitive-transactional models of stress and coping.

427 citations

Journal ArticleDOI
TL;DR: Akhmediev et al. as mentioned in this paper derived general high-order rogue waves in the nonlinear Schrodinger equation using the bilinear method and showed that the general N − 1 free irreducible complex parameters have the highest peak amplitudes among all rogue waves of the same order.
Abstract: General high-order rogue waves in the nonlinear Schrodinger equation are derived by the bilinear method. These rogue waves are given in terms of determinants whose matrix elements have simple algebraic expressions. It is shown that the general N -th order rogue waves contain N −1 free irreducible complex parameters. In addition, the specific rogue waves obtained by Akhmediev et al. (Akhmediev et al. 2009 Phys. Rev. E 80 , 026601 (doi:10.1103/PhysRevE.80.026601)) correspond to special choices of these free parameters, and they have the highest peak amplitudes among all rogue waves of the same order. If other values of these free parameters are taken, however, these general rogue waves can exhibit other solution dynamics such as arrays of fundamental rogue waves arising at different times and spatial positions and forming interesting patterns.

424 citations


Authors

Showing all 17727 results

NameH-indexPapersCitations
Albert Hofman2672530321405
Ralph B. D'Agostino2261287229636
George Davey Smith2242540248373
Stephen V. Faraone1881427140298
Valentin Fuster1791462185164
Dennis J. Selkoe177607145825
Anders Björklund16576984268
Alfred L. Goldberg15647488296
Christopher P. Cannon1511118108906
Debbie A Lawlor1471114101123
Roger J. Davis147498103478
Andrew S. Levey144600156845
Jonathan G. Seidman13756389782
Yu Huang136149289209
Christine E. Seidman13451967895
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202359
2022177
20211,840
20201,762
20191,653
20181,569