Showing papers by "University of Veterinary Science published in 1967"

Some characteristic features of the biotransport of the cytostatic agent 1,6‐dibromo‐1,6‐dideoxy‐dulcitol

Abstract: Aspects of the biological transport of cytostatically active 1,6-dibromo-1,6-dideoxydulcitol (DBD) were studied using 82Br-labelled material on dogs and Yoshida tumorbearing rats. Thirty-five per cent of the DBD dose was excreted in the urine within 12 hours. Besides unchanged DBD, metabolites containing C-Br bonds could also be detected in the urine. In vivo, the 50% decomposition time of the C-Br bonds in DBD is about 5 to 6 hours. One hour after administration of DBD, more than 50% of the persisting dose had entered the cells. Accumulation of the drug in the tumor tissue could not be demonstrated. A fraction of the dose enters the enterohepatic circulation.