Showing papers by "University of Victoria published in 2017"
TL;DR: The InTBIR Participants and Investigators have provided informed consent for the study to take place in Poland.
Abstract: Additional co-authors: Endre Czeiter, Marek Czosnyka, Ramon Diaz-Arrastia, Jens P Dreier, Ann-Christine Duhaime, Ari Ercole, Thomas A van Essen, Valery L Feigin, Guoyi Gao, Joseph Giacino, Laura E Gonzalez-Lara, Russell L Gruen, Deepak Gupta, Jed A Hartings, Sean Hill, Ji-yao Jiang, Naomi Ketharanathan, Erwin J O Kompanje, Linda Lanyon, Steven Laureys, Fiona Lecky, Harvey Levin, Hester F Lingsma, Marc Maegele, Marek Majdan, Geoffrey Manley, Jill Marsteller, Luciana Mascia, Charles McFadyen, Stefania Mondello, Virginia Newcombe, Aarno Palotie, Paul M Parizel, Wilco Peul, James Piercy, Suzanne Polinder, Louis Puybasset, Todd E Rasmussen, Rolf Rossaint, Peter Smielewski, Jeannette Soderberg, Simon J Stanworth, Murray B Stein, Nicole von Steinbuchel, William Stewart, Ewout W Steyerberg, Nino Stocchetti, Anneliese Synnot, Braden Te Ao, Olli Tenovuo, Alice Theadom, Dick Tibboel, Walter Videtta, Kevin K W Wang, W Huw Williams, Kristine Yaffe for the InTBIR Participants and Investigators
1,354 citations
University of Washington1, University of British Columbia2, Stanford University3, University of Guelph4, University of Saskatchewan5, American Museum of Natural History6, University of Victoria7, University of Wyoming8, University of Waterloo9, International Union for Conservation of Nature and Natural Resources10, Oregon State University11, Memorial University of Newfoundland12, Cornell University13, Colorado State University14, Slippery Rock University of Pennsylvania15, Georgia State University16
TL;DR: In this paper, the authors examine the scope and purpose of eighteen subfields of classic, interdisciplinary and applied conservation social sciences and articulates ten distinct contributions that the social sciences can make to understanding and improving conservation.
717 citations
University of Queensland1, University of the Witwatersrand2, University of Bristol3, University of East Anglia4, University of Arizona5, University of Münster6, Max Planck Society7, University of Ottawa8, Istituto Nazionale di Fisica Nucleare9, University of Glasgow10, Innsbruck Medical University11, State University of New York System12, The Institute of Optics13, Polytechnic University of Catalonia14, University of Victoria15, University of Southern California16, University of Oregon17, Purdue University18
TL;DR: In this paper, the key fields within structured light from the perspective of experts in those areas, providing insight into the current state and the challenges their respective fields face, as well as the exciting prospects for the future that are yet to be realized.
Abstract: Structured light refers to the generation and application of custom light fields. As the tools and technology to create and detect structured light have evolved, steadily the applications have begun to emerge. This roadmap touches on the key fields within structured light from the perspective of experts in those areas, providing insight into the current state and the challenges their respective fields face. Collectively the roadmap outlines the venerable nature of structured light research and the exciting prospects for the future that are yet to be realized.
639 citations
TL;DR: Focusing on different kinds of constraints on the controller and the self-dynamics of each individual agent, as well as the coordination schemes, the recent results are categorized into consensus with constraints, event-based consensus, consensus over signed networks, and consensus of heterogeneous agents.
Abstract: In this paper, we mainly review the topics in consensus and coordination of multi-agent systems, which have received a tremendous surge of interest and progressed rapidly in the past few years. Focusing on different kinds of constraints on the controller and the self-dynamics of each individual agent, as well as the coordination schemes, we categorize the recent results into the following directions: consensus with constraints, event-based consensus, consensus over signed networks, and consensus of heterogeneous agents. We also review some applications of the very well developed consensus algorithms to the topics such as economic dispatch problem in smart grid and k -means clustering algorithms.
595 citations
Carnegie Institution for Science1, University of California, Santa Cruz2, Carnegie Learning3, Lawrence Berkeley National Laboratory4, University of California, Berkeley5, Pennsylvania State University6, University of Copenhagen7, Space Telescope Science Institute8, Johns Hopkins University9, California Institute of Technology10, Massachusetts Institute of Technology11, Diego Portales University12, University of Notre Dame13, Joint Institute for Nuclear Astrophysics14, National Autonomous University of Mexico15, University of La Serena16, Herzberg Institute of Astrophysics17, University of Victoria18, Valparaiso University19, Texas A&M University20, Catholic University of the North21, Millennium Institute22, University of Sydney23
TL;DR: In this paper, the authors present ultraviolet, optical, and infrared light curves of SSS17a extending from 10.9 hours to 18 days post-merger, showing that the late-time light curve indicates that SSS 17a produced at least 0.05 solar masses of heavy elements, demonstrating that neutron star mergers play a role in rapid neutron capture (r-process) nucleosynthesis in the universe.
Abstract: On 17 August 2017, gravitational waves (GWs) were detected from a binary neutron star merger, GW170817, along with a coincident short gamma-ray burst, GRB 170817A. An optical transient source, Swope Supernova Survey 17a (SSS17a), was subsequently identified as the counterpart of this event. We present ultraviolet, optical, and infrared light curves of SSS17a extending from 10.9 hours to 18 days postmerger. We constrain the radioactively powered transient resulting from the ejection of neutron-rich material. The fast rise of the light curves, subsequent decay, and rapid color evolution are consistent with multiple ejecta components of differing lanthanide abundance. The late-time light curve indicates that SSS17a produced at least ~0.05 solar masses of heavy elements, demonstrating that neutron star mergers play a role in rapid neutron capture (r-process) nucleosynthesis in the universe.
582 citations
University of Paris-Sud1, University of Louisville2, Pierre-and-Marie-Curie University3, University of Bonn4, University of Zurich5, University of Manchester6, University of Warwick7, Aix-Marseille University8, Karlsruhe Institute of Technology9, Wayne State University10, Niigata University11, Nara Women's University12, University of Cambridge13, Ludwig Maximilian University of Munich14, Chinese Academy of Sciences15, University of Bristol16, Jožef Stefan Institute17, Spanish National Research Council18, Imperial College London19, University of Milano-Bicocca20, CERN21, University of Victoria22, École Polytechnique Fédérale de Lausanne23, University of Cincinnati24, Budker Institute of Nuclear Physics25, Novosibirsk State University26, Fermilab27, Graduate University for Advanced Studies28, KEK29, University of Melbourne30, Indiana University31, University of Florida32, University of Ljubljana33
TL;DR: In this article, the authors report world averages of measurements of b-hadron, c-, c-, and tau-lepton properties obtained by the Heavy Flavor Averaging Group (HFAG) using results available through the end of 2011.
Abstract: This article reports world averages of measurements of b-hadron, c-hadron, and tau-lepton properties obtained by the Heavy Flavor Averaging Group (HFAG) using results available through the end of 2011. In some cases results available in the early part of 2012 are included. For the averaging, common input parameters used in the various analyses are adjusted (rescaled) to common values, and known correlations are taken into account. The averages include branching fractions, lifetimes, neutral meson mixing parameters, CP violation parameters, parameters of semileptonic decays and CKM matrix elements.
554 citations
Princeton University1, University of Washington2, International Centre for Theoretical Physics3, INAF4, International School for Advanced Studies5, University of Nottingham6, Space Telescope Science Institute7, University of Victoria8, University of Chile9, University of Copenhagen10, Ohio State University11, Max Planck Society12
TL;DR: In this paper, the free-streaming of warm dark matter (WDM) from Lyman-α flux-power spectra was studied using hydrodynamical simulations.
Abstract: We present new measurements of the free-streaming of warm dark matter (WDM) from Lyman-α flux-power spectra. We use data from the medium resolution, intermediate redshift XQ-100 sample observed with the X-shooter spectrograph (z = 3 – 4.2) and the high-resolution, high-redshift sample used in Viel et al. (2013) obtained with the HIRES/MIKE spectrographs (z = 4.2 - 5.4). Based on further improved modelling of the dependence of the Lyman-α flux-power spectrum on the free-streaming of dark matter, cosmological parameters, as well as the thermal history of the intergalactic medium (IGM) with hydrodynamical simulations, we obtain the following limits, expressed as the equivalent mass of thermal relic WDM particles. The XQ-100 flux power spectrum alone gives a lower limit of 1.4 keV, the re-analysis of the HIRES/MIKE sample gives 4.1 keV while the combined analysis gives our best and significantly strengthened lower limit of 5.3 keV (all 2σ C.L.). The further improvement in the joint analysis is partly due to the fact that the two data sets have different degeneracies between astrophysical and cosmological parameters that are broken when the data sets are combined, and more importantly on chosen priors on the thermal evolution. These results all assume that the temperature evolution of the IGM can be modelled as a power law in redshift. Allowing for a non-smooth evolution of the temperature of the IGM with sudden temperature changes of up to 5000K reduces the lower limit for the combined analysis to 3.5 keV. A WDM with smaller thermal relic masses would require, however, a sudden temperature jump of 5000K or more in the narrow redshift interval z = 4.6 - 4.8, in disagreement with observations of the thermal history based on high-resolution resolution Lyman-α forest data and expectations for photo-heating and cooling in the low density IGM at these redshifts.
510 citations
TL;DR: It is proposed that the discussion section of all primary research articles specify Constraints on Generality (i.e., a “COG” statement) that identify and justify target populations for the reported findings, to change publishing incentives to favor a more cumulative science.
Abstract: Psychological scientists draw inferences about populations based on samples-of people, situations, and stimuli-from those populations. Yet, few papers identify their target populations, and even fewer justify how or why the tested samples are representative of broader populations. A cumulative science depends on accurately characterizing the generality of findings, but current publishing standards do not require authors to constrain their inferences, leaving readers to assume the broadest possible generalizations. We propose that the discussion section of all primary research articles specify Constraints on Generality (i.e., a "COG" statement) that identify and justify target populations for the reported findings. Explicitly defining the target populations will help other researchers to sample from the same populations when conducting a direct replication, and it could encourage follow-up studies that test the boundary conditions of the original finding. Universal adoption of COG statements would change publishing incentives to favor a more cumulative science.
506 citations
TL;DR: This paper presents a short overview of the changes to the trigger and data acquisition systems during the first long shutdown of the LHC and shows the performance of the trigger system and its components based on the 2015 proton–proton collision data.
Abstract: During 2015 the ATLAS experiment recorded 3.8 fb(-1) of proton-proton collision data at a centre-of-mass energy of 13 TeV. The ATLAS trigger system is a crucial component of the experiment, respons ...
488 citations
University of Melbourne1, Université libre de Bruxelles2, Katholieke Universiteit Leuven3, University of Victoria4, St. Vincent's Health System5, La Trobe University6, Royal Melbourne Hospital7, Netherlands Cancer Institute8, University of California, San Diego9, Vanderbilt University10, Peter MacCallum Cancer Centre11, University of Antwerp12, French Institute of Health and Medical Research13, University of Paris14, Medical University of Vienna15, Cornell University16, University of Texas MD Anderson Cancer Center17, Mayo Clinic18, Royal Brisbane and Women's Hospital19, University of Queensland20, Harvard University21, Novartis22, Indiana University – Purdue University Indianapolis23, Fred Hutchinson Cancer Research Center24, University of Milan25, University of Auvergne26, Kansai Medical University27, Yeshiva University28, Yonsei University29, Rhode Island Hospital30, Brown University31, Curie Institute32, Charité33, Yale University34, University of British Columbia35, Garvan Institute of Medical Research36, Université Paris-Saclay37, Autonomous University of Madrid38, University of Ottawa39, National Institutes of Health40, New York University41, University of Adelaide42, Stanford University43, Anschutz Medical Campus44, University of Padua45, European Organisation for Research and Treatment of Cancer46, Medical University of Graz47, Hoffmann-La Roche48, Genentech49, MedImmune50, Merck & Co.51, Memorial Sloan Kettering Cancer Center52
TL;DR: Standardization of TIL assessment will help clinicians, researchers and pathologists to conclusively evaluate the utility of this simple biomarker in the current era of immunotherapy.
Abstract: Assessment of the immune response to tumors is growing in importance as the prognostic implications of this response are increasingly recognized, and as immunotherapies are evaluated and implemented in different tumor types. However, many different approaches can be used to assess and describe the immune response, which limits efforts at implementation as a routine clinical biomarker. In part 1 of this review, we have proposed a standardized methodology to assess tumor-infiltrating lymphocytes (TILs) in solid tumors, based on the International Immuno-Oncology Biomarkers Working Group guidelines for invasive breast carcinoma. In part 2 of this review, we discuss the available evidence for the prognostic and predictive value of TILs in common solid tumors, including carcinomas of the lung, gastrointestinal tract, genitourinary system, gynecologic system, and head and neck, as well as primary brain tumors, mesothelioma and melanoma. The particularities and different emphases in TIL assessment in different tumor types are discussed. The standardized methodology we propose can be adapted to different tumor types and may be used as a standard against which other approaches can be compared. Standardization of TIL assessment will help clinicians, researchers and pathologists to conclusively evaluate the utility of this simple biomarker in the current era of immunotherapy.
477 citations
Posted Content•
TL;DR: The white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in Dark Matter" held at University of Maryland on March 23-25, 2017.
Abstract: This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in Dark Matter" held at University of Maryland on March 23-25, 2017.
TL;DR: PA research should continue to examine the mechanisms causing health outcomes, the dose that can lead to clinically relevant changes in health status, the scope and validity of PA surveillance and innovative behaviour change techniques, while improving the reach and duration of PA interventions.
Abstract: Objective: To provide a broad overview of the state of physical activity (PA) research in the form of (1) definitions of PA, (2) health benefits, (3) prevalence, (4) correlates and (5) interventions.Design: A high-level overview of published reviews of the literature.Results: Regular PA is an effective primary and secondary preventative strategy against at least 25 chronic medical conditions with risk reduction typically in the 20–30% range. While approximately 75% of adults meet recommended PA guidelines, the prevalence is slightly lower for women compared to men, and considerably lower for youth, older adults and those in higher income countries. Motivation, self-efficacy and self-regulation remain consistent correlates of PA. Interventions show PA changes in the small effect size range for adults and youth but the heterogeneity is considerable across studies. Only a few (aggregate of behavioural regulation strategies, supervision, high frequency of contact) reliable moderators of intervention success w...
TL;DR: Topological cell clustering is established as a well-performing calorimeter signal definition for jet and missing transverse momentum reconstruction in ATLAS and is exploited to apply a local energy calibration and corrections depending on the nature of the cluster.
Abstract: The reconstruction of the signal from hadrons and jets emerging from the proton–proton collisions at the Large Hadron Collider (LHC) and entering the ATLAS calorimeters is based on a three-dimensional topological clustering of individual calorimeter cell signals. The cluster formation follows cell signal-significance patterns generated by electromagnetic and hadronic showers. In this, the clustering algorithm implicitly performs a topological noise suppression by removing cells with insignificant signals which are not in close proximity to cells with significant signals. The resulting topological cell clusters have shape and location information, which is exploited to apply a local energy calibration and corrections depending on the nature of the cluster. Topological cell clustering is established as a well-performing calorimeter signal definition for jet and missing transverse momentum reconstruction in ATLAS.
TL;DR: The results advance the understanding of how suicidal Ideation changes over short periods and provide a novel method of improving the short-term prediction of suicidal ideation.
Abstract: Two studies examined 2 important but previously unanswered questions about the experience of suicidal ideation: (a) How does suicidal ideation vary over short periods of time?, and (b) To what degree do risk factors for suicidal ideation vary over short periods and are such changes associated with changes in suicidal ideation? Participants in Study 1 were 54 adults who had attempted suicide in the previous year and completed 28 days of ecological momentary assessment (EMA; average of 2.51 assessments per day; 2,891 unique assessments). Participants in Study 2 were 36 adult psychiatric inpatients admitted for suicide risk who completed EMA throughout their time in the hospital (average stay of 10.32 days; average 2.48 assessments per day; 649 unique assessments). These studies revealed 2 key findings: (a) For nearly all participants, suicidal ideation varied dramatically over the course of most days: more than 1-quarter (Study 1 = 29%; Study 2 = 28%) of all ratings of suicidal ideation were a standard deviation above or below the previous response from a few hours earlier and nearly all (Study 1 = 94.1%; Study 2 = 100%) participants had at least 1 instance of intensity of suicidal ideation changing by a standard deviation or more from 1 response to the next. (b) Across both studies, well-known risk factors for suicidal ideation such as hopelessness, burdensomeness, and loneliness also varied considerably over just a few hours and correlated with suicidal ideation, but were limited in predicting short-term change in suicidal ideation. These studies represent the most fine-grained examination of suicidal ideation ever conducted. The results advance the understanding of how suicidal ideation changes over short periods and provide a novel method of improving the short-term prediction of suicidal ideation. (PsycINFO Database Record
University of Melbourne1, Université libre de Bruxelles2, Katholieke Universiteit Leuven3, St. Vincent's Health System4, La Trobe University5, Royal Melbourne Hospital6, Netherlands Cancer Institute7, University of California, San Diego8, Vanderbilt University9, Peter MacCallum Cancer Centre10, University of Paris11, French Institute of Health and Medical Research12, Medical University of Vienna13, Cornell University14, University of Texas MD Anderson Cancer Center15, Mayo Clinic16, Royal Brisbane and Women's Hospital17, University of Queensland18, Harvard University19, Novartis20, Indiana University – Purdue University Indianapolis21, Fred Hutchinson Cancer Research Center22, University of Milan23, University of Auvergne24, Kansai Medical University25, Yeshiva University26, Yonsei University27, Rhode Island Hospital28, Brown University29, Curie Institute30, Charité31, Yale University32, University of British Columbia33, University of Victoria34, Garvan Institute of Medical Research35, Université Paris-Saclay36, Autonomous University of Madrid37, University of Ottawa38, National Institutes of Health39, New York University40, University of Adelaide41, Stanford University42, Anschutz Medical Campus43, University of Padua44, European Organisation for Research and Treatment of Cancer45, Medical University of Graz46, Hoffmann-La Roche47, Genentech48, MedImmune49, Merck & Co.50, Memorial Sloan Kettering Cancer Center51
TL;DR: In this paper, a standardized methodology to assess tumor-infiltrating lymphocytes (TILs) in solid tumors on hematoxylin and eosin sections, in both primary and metastatic settings, was proposed.
Abstract: Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can provide important prognostic information in diverse solid tumor types, and may also be of value in predicting response to treatments. However, implementation as a routine clinical biomarker has not yet been achieved. As successful use of immune checkpoint inhibitors and other forms of immunotherapy become a clinical reality, the need for widely applicable, accessible, and reliable immunooncology biomarkers is clear. In part 1 of this review we briefly discuss the host immune response to tumors and different approaches to TIL assessment. We propose a standardized methodology to assess TILs in solid tumors on hematoxylin and eosin sections, in both primary and metastatic settings, based on the International Immuno-Oncology Biomarker Working Group guidelines for TIL assessment in invasive breast carcinoma. A review of the literature regarding the value of TIL assessment in different solid tumor types follows in part 2. The method we propose is reproducible, affordable, easily applied, and has demonstrated prognostic and predictive significance in invasive breast carcinoma. This standardized methodology may be used as a reference against which other methods are compared, and should be evaluated for clinical validity and utility. Standardization of TIL assessment will help to improve consistency and reproducibility in this field, enrich both the quality and quantity of comparable evidence, and help to thoroughly evaluate the utility of TILs assessment in this era of immunotherapy.
TL;DR: Among adults with RCDI, FMT via oral capsules was not inferior to delivery by colonoscopy for preventing recurrent infection over 12 weeks and treatment with oral capsules may be an effective approach to treating RCDi.
Abstract: Importance Fecal microbiota transplantation (FMT) is effective in preventing recurrentClostridium difficileinfection (RCDI). However, it is not known whether clinical efficacy differs by route of delivery. Objective To determine whether FMT by oral capsule is noninferior to colonoscopy delivery in efficacy. Design, Setting, and Participants Noninferiority, unblinded, randomized trial conducted in 3 academic centers in Alberta, Canada. A total of 116 adult patients with RCDI were enrolled between October 2014 and September 2016, with follow-up to December 2016. The noninferiority margin was 15%. Interventions Participants were randomly assigned to FMT by capsule or by colonoscopy at a 1:1 ratio. Main Outcomes and Measures The primary outcome was the proportion of patients without RCDI 12 weeks after FMT. Secondary outcomes included (1) serious and minor adverse events, (2) changes in quality of life by the 36-Item Short Form Survey on a scale of 0 (worst possible quality of life) to 100 (best quality of life), and (3) patient perception on a scale of 1 (not at all unpleasant) to 10 (extremely unpleasant) and satisfaction on a scale of 1 (best) to 10 (worst). Results Among 116 patients randomized (mean [SD] age, 58 [19] years; 79 women [68%]), 105 (91%) completed the trial, with 57 patients randomized to the capsule group and 59 to the colonoscopy group. In per-protocol analysis, prevention of RCDI after a single treatment was achieved in 96.2% in both the capsule group (51/53) and the colonoscopy group (50/52) (difference, 0%; 1-sided 95% CI, −6.1% to infinity;P Conclusions and Relevance Among adults with RCDI, FMT via oral capsules was not inferior to delivery by colonoscopy for preventing recurrent infection over 12 weeks. Treatment with oral capsules may be an effective approach to treating RCDI. Trial Registration clinicaltrials.gov Identifier:NCT02254811
Harvard University1, University of Victoria2, University of Chicago3, Ben-Gurion University of the Negev4, University of St Andrews5, Australian National University6, Williams College7, Curtin University8, University of Adelaide9, Oregon State University10, Institut de recherche pour le développement11, Université Paris-Saclay12, Smithsonian Institution13, Santa Fe Institute14, University of Birmingham15, University of Reading16, Wheaton College (Massachusetts)17, McGill University18, Institut de Physique du Globe de Paris19, University of California, Riverside20, Princeton University21, University of Saskatchewan22, University at Albany, SUNY23, Trinity College, Dublin24, Karlsruhe Institute of Technology25, Lamont–Doherty Earth Observatory26, University of Washington27
TL;DR: Modeling shows that the small thermal inertia of a globally frozen surface reverses the annual mean tropical atmospheric circulation, producing an equatorial desert and net snow and frost accumulation elsewhere, and that the evolutionary legacy of Snowball Earth is perceptible in fossils and living organisms.
Abstract: Geological evidence indicates that grounded ice sheets reached sea level at all latitudes during two long-lived Cryogenian (58 and ≥5 My) glaciations. Combined uranium-lead and rhenium-osmium dating suggests that the older (Sturtian) glacial onset and both terminations were globally synchronous. Geochemical data imply that CO2 was 102 PAL (present atmospheric level) at the younger termination, consistent with a global ice cover. Sturtian glaciation followed breakup of a tropical supercontinent, and its onset coincided with the equatorial emplacement of a large igneous province. Modeling shows that the small thermal inertia of a globally frozen surface reverses the annual mean tropical atmospheric circulation, producing an equatorial desert and net snow and frost accumulation elsewhere. Oceanic ice thickens, forming a sea glacier that flows gravitationally toward the equator, sustained by the hydrologic cycle and by basal freezing and melting. Tropical ice sheets flow faster as CO2 rises but lose mass and become sensitive to orbital changes. Equatorial dust accumulation engenders supraglacial oligotrophic meltwater ecosystems, favorable for cyanobacteria and certain eukaryotes. Meltwater flushing through cracks enables organic burial and submarine deposition of airborne volcanic ash. The subglacial ocean is turbulent and well mixed, in response to geothermal heating and heat loss through the ice cover, increasing with latitude. Terminal carbonate deposits, unique to Cryogenian glaciations, are products of intense weathering and ocean stratification. Whole-ocean warming and collapsing peripheral bulges allow marine coastal flooding to continue long after ice-sheet disappearance. The evolutionary legacy of Snowball Earth is perceptible in fossils and living organisms.
TL;DR: A holistic view of surface reconstruction is considered, which shows a detailed characterization of the field, highlights similarities between diverse reconstruction techniques and provides directions for future work in surface reconstruction.
Abstract: The area of surface reconstruction has seen substantial progress in the past two decades. The traditional problem addressed by surface reconstruction is to recover the digital representation of a physical shape that has been scanned, where the scanned data contain a wide variety of defects. While much of the earlier work has been focused on reconstructing a piece-wise smooth representation of the original shape, recent work has taken on more specialized priors to address significantly challenging data imperfections, where the reconstruction can take on different representations-not necessarily the explicit geometry. We survey the field of surface reconstruction, and provide a categorization with respect to priors, data imperfections and reconstruction output. By considering a holistic view of surface reconstruction, we show a detailed characterization of the field, highlight similarities between diverse reconstruction techniques and provide directions for future work in surface reconstruction.
TL;DR: Both long-acting regimens met primary criteria for comparability in viral suppression relative to the oral comparator group and the primary analysis used a Bayesian approach to evaluate the hypothesis that the proportion with viral suppression for each long- acting regimen is not worse than the oral regimen proportion.
TL;DR: This primer article focuses on the basic reproduction number, ℛ0, for infectious diseases, and other reproduction numbers related to ℚ0 that are useful in guiding control strategies and theoretical ideas are applied to models that are formulated.
TL;DR: This paper reviewed essential features of subjective cognitive decline associated with preclinical AD and current measurement approaches, highlighting challenges in harmonizing study findings across settings, and examined the role of self-and informant-reports in SCD and various psychological, medical, and demographic factors that influence the self-report of cognition.
Abstract: Older adults with subjective cognitive decline (SCD) in the absence of objective neuropsychological dysfunction are increasingly viewed as at risk for non-normative cognitive decline and eventual progression to Alzheimer's disease (AD) dementia. The past decade has witnessed tremendous growth in research on SCD, which may reflect the recognition of SCD as the earliest symptomatic manifestation of AD. Yet methodological challenges associated with establishing common assessment and classification procedures hamper the construct. This article reviews essential features of SCD associated with preclinical AD and current measurement approaches, highlighting challenges in harmonizing study findings across settings. We consider the relation of SCD to important variables and outcomes (e.g., AD biomarkers, clinical progression). We also examine the role of self- and informant-reports in SCD and various psychological, medical, and demographic factors that influence the self-report of cognition. We conclude with a di...
ETH Zurich1, University of Ulm2, Vrije Universiteit Brussel3, Royal Museum for Central Africa4, University of Coimbra5, University of Helsinki6, University of Victoria7, University of Innsbruck8, University of Milan9, Czech University of Life Sciences Prague10, Spanish National Research Council11, Swiss Federal Institute for Forest, Snow and Landscape Research12, Institut national de la recherche agronomique13, Laval University14, University of Ljubljana15, United States Geological Survey16, Ben-Gurion University of the Negev17, Center for International Forestry Research18, Technical University of Berlin19, Dresden University of Technology20, University of Kansas21, University of Arkansas22, Max Planck Society23, National Museum of Natural History24, Desert Botanical Garden25, Humboldt State University26, Sukachev Institute of Forest27, National Scientific and Technical Research Council28, National University of Comahue29, Agricultural Research Organization, Volcani Center30, Wageningen University and Research Centre31, Naturalis32, Pablo de Olavide University33, Autonomous University of Barcelona34, University of Lisbon35, Mediterranean University36, Technical University of Madrid37, University of Western Sydney38, University of Debrecen39, Natural Resources Canada40, American Hotel & Lodging Educational Institute41, University of Cyprus42, University of Patras43, Open University of Cyprus44, University of Colorado Boulder45, Northern Arizona University46, University of Novi Sad47, European Forest Institute48, Estonian University of Life Sciences49, University of Alberta50, University of Minnesota51, University of Forestry, Sofia52
TL;DR: The results imply that growth-based mortality algorithms may be a powerful tool for predicting gymnosperm mortality induced by chronic stress, but not necessarily so for angiosperms and in case of intense drought or bark-beetle outbreaks.
Abstract: Tree mortality is a key factor influencing forest functions and dynamics, but our understanding of the mechanisms
leading to mortality and the associated changes in tree growth rates are still limited. We compiled a new pan-conti-
nental tree-ring width database from sites where both dead and living trees were sampled (2970 dead and 4224 living
trees from 190 sites, including 36 species), and compared early and recent growth rates between trees that died and
those that survived a given mortality event. We observed a decrease in radial growth before death in ca. 84% of the
mortality events. The extent and duration of these reductions were highly variable (1–100 years in 96% of events) due
to the complex interactions among study species and the source(s) of mortality. Strong and long-lasting declines were
found for gymnosperms, shade- and drought-tolerant species, and trees that died from competition. Angiosperms
and trees that died due to biotic attacks (especially bark-beetles) typically showed relatively small and short-term
growth reductions. Our analysis did not highlight any universal trade-off between early growth and tree longevity
within a species, although this result may also reflect high variability in sampling design among sites. The intersite
and interspecific variability in growth patterns before mortality provides valuable information on the nature of the
mortality process, which is consistent with our understanding of the physiological mechanisms leading to mortality.
Abrupt changes in growth immediately before death can be associated with generalized hydraulic failure and/or
bark-beetle attack, while long-term decrease in growth may be associated with a gradual decline in hydraulic performance coupled with depletion in carbon reserves. Our results imply that growth-based mortality algorithms may be
a powerful tool for predicting gymnosperm mortality induced by chronic stress, but not necessarily so for angiosperms and in case of intense drought or bark-beetle outbreaks.
Beta1, Albert Einstein College of Medicine2, The Graduate Center, CUNY3, Brigham and Women's Hospital4, University of Melbourne5, Florey Institute of Neuroscience and Mental Health6, Pierre-and-Marie-Curie University7, Ludwig Maximilian University of Munich8, AXA9, University Medical Center Freiburg10, New York University11, Indiana University12, VU University Medical Center13, University of Victoria14, University of Pittsburgh15, University of Bonn16
TL;DR: In this article, the Subjective Cognitive Decline Initiative (SCD-I) published research criteria in the context of preclinical AD, with the aim of harmonization of SCD measurement across studies to enhance comparability and generalizability across studies.
Abstract: Introduction Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. Methods Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly. Results Topics included SCD inclusion and exclusion criteria, together with the informant's role in defining SCD presence and the impact of demographic factors. Discussion Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are proposed, to enhance comparability and generalizability across studies.
McMaster University1, University of Calgary2, Geneva College3, University of Oslo4, Aarhus University Hospital5, University of Oxford6, University of Western Ontario7, University of Toronto8, McGill University9, Dalhousie University10, Columbia University11, Katholieke Universiteit Leuven12, Aarhus University13, University of Hong Kong14, Henry Ford Hospital15, Post Graduate Institute of Medical Education and Research16, Mayo Clinic17, Shanghai Jiao Tong University18, University of California19, University of New Mexico20, Universidade de Pernambuco21, University of Sheffield22, University of Pisa23, Yale University24, University of Victoria25, Harvard University26, University of Florence27
TL;DR: The current state of the art in the diagnosis and management ofPHPT is presented and the Canadian Position paper on PHPT is updated and an overview of the impact of PHPT on the skeleton and other target organs is presented.
Abstract: The purpose of this review is to assess the most recent evidence in the management of primary hyperparathyroidism (PHPT) and provide updated recommendations for its evaluation, diagnosis and treatment. A Medline search of "Hyperparathyroidism. Primary" was conducted and the literature with the highest levels of evidence were reviewed and used to formulate recommendations. PHPT is a common endocrine disorder usually discovered by routine biochemical screening. PHPT is defined as hypercalcemia with increased or inappropriately normal plasma parathyroid hormone (PTH). It is most commonly seen after the age of 50 years, with women predominating by three to fourfold. In countries with routine multichannel screening, PHPT is identified earlier and may be asymptomatic. Where biochemical testing is not routine, PHPT is more likely to present with skeletal complications, or nephrolithiasis. Parathyroidectomy (PTx) is indicated for those with symptomatic disease. For asymptomatic patients, recent guidelines have recommended criteria for surgery, however PTx can also be considered in those who do not meet criteria, and prefer surgery. Non-surgical therapies are available when surgery is not appropriate. This review presents the current state of the art in the diagnosis and management of PHPT and updates the Canadian Position paper on PHPT. An overview of the impact of PHPT on the skeleton and other target organs is presented with international consensus. Differences in the international presentation of this condition are also summarized.
TL;DR: Limits on the coupling strength of A^{'} to e^{+}e^{-} in the mass range m_{A^{'}}≤8 GeV are set, which exclude the values of the A^' coupling suggested by thedark-photon interpretation of the muon (g-2)_{μ} anomaly, as well as a broad range of parameters for the dark-sector models.
Abstract: We search for single-photon events in 53 fb^{-1} of e^{+}e^{-} collision data collected with the BABAR detector at the PEP-II B-Factory. We look for events with a single high-energy photon and a large missing momentum and energy, consistent with production of a spin-1 particle A^{'} through the process e^{+}e^{-}→γA^{'}; A^{'}→invisible. Such particles, referred to as "dark photons," are motivated by theories applying a U(1) gauge symmetry to dark matter. We find no evidence for such processes and set 90% confidence level upper limits on the coupling strength of A^{'} to e^{+}e^{-} in the mass range m_{A^{'}}≤8 GeV. In particular, our limits exclude the values of the A^{'} coupling suggested by the dark-photon interpretation of the muon (g-2)_{μ} anomaly, as well as a broad range of parameters for the dark-sector models.
TL;DR: In this paper, a systematic review of the literature on theory building in management around the five key elements of a good story is presented, namely conflict, character, setting, sequence, and plot and arc.
TL;DR: In this article, a search for new resonant and non-resonant high-mass phenomena in dielectron and dimuon fi nal states was conducted using 36 : 1 fb(-1) of proton-proton collision data.
Abstract: A search is conducted for new resonant and non-resonant high-mass phenomena in dielectron and dimuon fi nal states. The search uses 36 : 1 fb(-1) of proton-proton collision data, collected at root ...
Carnegie Institution for Science1, University of California, Santa Cruz2, Carnegie Learning3, Lawrence Berkeley National Laboratory4, University of California, Berkeley5, Pennsylvania State University6, University of Copenhagen7, Johns Hopkins University8, Space Telescope Science Institute9, California Institute of Technology10, Diego Portales University11, Massachusetts Institute of Technology12, Joint Institute for Nuclear Astrophysics13, University of Notre Dame14, National Autonomous University of Mexico15, University of La Serena16, Herzberg Institute of Astrophysics17, University of Victoria18, Valparaiso University19, Texas A&M University20, Catholic University of the North21, Millennium Institute22, University of Sydney23
TL;DR: The late-time light curve indicates that SSS17a produced at least ~0.05 solar masses of heavy elements, demonstrating that neutron star mergers play a role in rapid neutron capture (r-process) nucleosynthesis in the universe.
Abstract: On 2017 August 17, gravitational waves were detected from a binary neutron star merger, GW170817, along with a coincident short gamma-ray burst, GRB170817A. An optical transient source, Swope Supernova Survey 17a (SSS17a), was subsequently identified as the counterpart of this event. We present ultraviolet, optical and infrared light curves of SSS17a extending from 10.9 hours to 18 days post-merger. We constrain the radioactively-powered transient resulting from the ejection of neutron-rich material. The fast rise of the light curves, subsequent decay, and rapid color evolution are consistent with multiple ejecta components of differing lanthanide abundance. The late-time light curve indicates that SSS17a produced at least ~0.05 solar masses of heavy elements, demonstrating that neutron star mergers play a role in r-process nucleosynthesis in the Universe.
TL;DR: Non‐invasive strategies such as caloric restriction, physical exercise, and environmental enrichment have been shown to counteract many of the age‐induced alterations in hippocampal signalling, structure, and function, and such approaches may have therapeutic value in counteracting the deleterious effects of aging and protecting the brain against age‐associated neurodegenerative processes.
International Union for Conservation of Nature and Natural Resources1, University of Washington2, University of British Columbia3, University of Guelph4, University of Saskatchewan5, American Museum of Natural History6, University of Waterloo7, Oregon State University8, Cornell University9, Colorado State University10, Slippery Rock University of Pennsylvania11, University of Victoria12, Memorial University of Newfoundland13, Georgia State University14
TL;DR: Mainstreaming the conservation social sciences will facilitate the uptake of the full range of insights and contributions from these fields into conservation policy and practice and enable more ecologically effective and socially just conservation.
Abstract: Despite broad recognition of the value of social sciences and increasingly vocal calls for better engagement with the human element of conservation, the conservation social sciences remain misunderstood and underutilized in practice. The conservation social sciences can provide unique and important contributions to society's understanding of the relationships between humans and nature and to improving conservation practice and outcomes. There are 4 barriers—ideological, institutional, knowledge, and capacity—to meaningful integration of the social sciences into conservation. We provide practical guidance on overcoming these barriers to mainstream the social sciences in conservation science, practice, and policy. Broadly, we recommend fostering knowledge on the scope and contributions of the social sciences to conservation, including social scientists from the inception of interdisciplinary research projects, incorporating social science research and insights during all stages of conservation planning and implementation, building social science capacity at all scales in conservation organizations and agencies, and promoting engagement with the social sciences in and through global conservation policy-influencing organizations. Conservation social scientists, too, need to be willing to engage with natural science knowledge and to communicate insights and recommendations clearly. We urge the conservation community to move beyond superficial engagement with the conservation social sciences. A more inclusive and integrative conservation science—one that includes the natural and social sciences—will enable more ecologically effective and socially just conservation. Better collaboration among social scientists, natural scientists, practitioners, and policy makers will facilitate a renewed and more robust conservation. Mainstreaming the conservation social sciences will facilitate the uptake of the full range of insights and contributions from these fields into conservation policy and practice.