University of Victoria

About: University of Victoria is a education organization based out in Victoria, British Columbia, Canada. It is known for research contribution in the topics: Population & Galaxy. The organization has 14994 authors who have published 41051 publications receiving 1447972 citations. The organization is also known as: Victoria College.

Mutations of the forkhead/winged-helix gene, FKHL7, in patients with Axenfeld-Rieger anomaly.

Abstract: Genetic linkage, genome mismatch scanning, and analysis of patients with alterations of chromosome 6 have indicated that a major locus for development of the anterior segment of the eye, IRID1, is located at 6p25. Abnormalities of this locus lead to glaucoma. FKHL7 (also called "FREAC3"), a member of the forkhead/winged-helix transcription-factor family, has also been mapped to 6p25. DNA sequencing of FKHL7 in five IRID1 families and 16 sporadic patients with anterior-segment defects revealed three mutations: a 10-bp deletion predicted to cause a frameshift and premature protein truncation prior to the FKHL7 forkhead DNA-binding domain, as well as two missense mutations of conserved amino acids within the FKHL7 forkhead domain. Mf1, the murine homologue of FKHL7, is expressed in the developing brain, skeletal system, and eye, consistent with FKHL7 having a role in ocular development. However, mutational screening and genetic-linkage analyses excluded FKHL7 from underlying the anterior-segment disorders in two IRID1 families with linkage to 6p25. Our findings demonstrate that, although mutations of FKHL7 result in anterior-segment defects and glaucoma in some patients, it is probable that at least one more locus involved in the regulation of eye development is also located at 6p25.

Towards Hydrodynamics without an Entropy Current

Abstract: We present a generating functional which describes the equilibrium thermodynamic response of a relativistic system to external sources. A variational principle gives rise to constraints on the response parameters of relativistic hydrodynamics without making use of an entropy current. Our method reproduces and extends results available in the literature. It also provides a technique for efficiently computing $n$-point zero-frequency correlation functions within the hydrodynamic derivative expansion without the need to explicitly solve the equations of hydrodynamics.

Passion in sport: a look at determinants and affective experiences.

Abstract: Based on the Dualistic Model of Passion (Vallerand et al., 2003), a sequence involving the determinants and affective experiences associated with two types of passion (harmonious and obsessive) toward sport was proposed and tested. This sequence posits that high levels of sport valuation and an autonomous personality orientation lead to harmonious passion, whereas high levels of sport valuation and a controlled personality orientation facilitate obsessive passion. In turn, harmonious passion is expected to lead to positive affective experiences in sport but to be either negatively related or unrelated to negative affective experiences. Conversely, obsessive passion is hypothesized to be positively related to negative affective experiences in sport but to be either negatively related or unrelated to positive affective experiences. Results of three studies conducted with recreational and competitive athletes involved in individual and team sports provided support for the proposed integrative sequence. These...

Paradigms of growth in fish.

Abstract: Most fish are indeterminate growers with white muscle making up the majority of the acquired bulk. Within the muscle, the myofibrillar fraction accounts for almost two-thirds of the protein synthetic activity, implying that it is accretion of myofibrillar proteins that makes the single most important contribution to fish growth. Fish muscle growth itself is not linear and occurs through a combination of hyperplasia and hypertrophy in post-juvenile stages. Superimposed on periodicity of growth in length and mass can be other phases governed by lunar, reproductive or circannual cycles. Data on fish growth are discussed in the framework of site-specific muscle abundance, metabolic and functional zonation of muscle, proliferation and differentiation of satellite cells and the contribution of myofibrillar proteins. Hormonal control of muscle growth is described against the backdrop of plasma availability of myogens (insulin, IGF-I, growth hormone), distribution and dynamics of their respective receptors, and their interactions. Important contributions of the ‘supply side’ are discussed with hormones regulating amino acid resorption from the intestine, intestinal growth, liver processing and amino acid uptake by the muscle. Data are also interpreted from metabolic angles, to explain lipolytic and nitrogen-sparing effects of growth hormones, and lipogenic effects of insulin and high protein diets. Finally, special attention is devoted to the multifaceted roles of arginine in fish growth, as precursor, intermediate and hormone secretagogue.