University of Vienna

About: University of Vienna is a education organization based out in Vienna, Austria. It is known for research contribution in the topics: Population & Stars. The organization has 44686 authors who have published 95840 publications receiving 2907492 citations.

The Kepler characterization of the variability among A- and F-type stars I. General overview

Abstract: Context. The Kepler spacecraft is providing time series of photometric data with micromagnitude precision for hundreds of A-F type stars. Aims. We present a first general characterization of the pulsational behaviour of A-F type stars as observed in the Kepler light curves of a sample of 750 candidate A-F type stars, and observationally investigate the relation between γ Doradus (γ Dor), δ Scuti (δ Sct), and hybrid stars. Methods. We compile a database of physical parameters for the sample stars from the literature and new ground-based observations. We analyse the Kepler light curve of each star and extract the pulsational frequencies using different frequency analysis methods. We construct two new observables, “energy ”a nd “efficiency”, related to the driving energy of the pulsation mode and the convective efficiency of the outer convective zone, respectively. Results. We propose three main groups to describe the observed variety in pulsating A-F type stars: γ Dor, δ Sct, and hybrid stars. We assign 63% of our sample to one of the three groups, and identify the remaining part as rotationally modulated/active stars, binaries, stars of different spectral type, or stars that show no clear periodic variability. 23% of the stars (171 stars) are hybrid stars, which is a much higher fraction than what has been observed before. We characterize for the first time a large number of A-F type stars (475 stars) in terms of number of detected frequencies, frequency range, and typical pulsation amplitudes. The majority of hybrid stars show frequencies with all kinds of periodicities within the γ Dor and δ Sct range, also between 5 and 10 d −1 , which is a challenge for the current models. We find indications for the existence of δ Sct and γ Dor stars beyond the edges of the current observational instability strips. The hybrid stars occupy the entire region within the δ Sct and γ Dor instability strips and beyond. Non-variable stars seem to exist within the instability strips. The location of γ Dor and δ Sct classes in the (Teff ,l ogg)-diagram has been extended. We investigate two newly constructed variables, “efficiency ”a nd “energy”, as a means to explore the relation between γ Dor and δ Sct stars. Conclusions. Our results suggest a revision of the current observational instability strips of δ Sct and γ Dor stars and imply an investigation of pulsation mechanisms to supplement the κ mechanism and convective blocking effect to drive hybrid pulsations. Accurate physical parameters for all stars are needed to confirm these findings.

Financial Network Systemic Risk Contributions

Abstract: We propose the realized systemic risk beta as a measure for financial companies’ contribution to systemic risk given network interdependence between firms’ tail risk exposures. Conditional on statistically pre-identified network spillover effects and market and balance sheet information, we define the realized systemic risk beta as the total time-varying marginal effect of a firm’s Value-at-Risk (VaR) on the system’s VaR. Suitable statistical inference reveals a multitude of relevant risk spillover channels and determines companies’ systemic importance in the U.S. financial system. Our approach can be used to monitor companies’ systemic importance allowing for a transparent macroprudential regulation.

Effect of Bafilomycin A1 and Nocodazole on Endocytic Transport in HeLa Cells: Implications for Viral Uncoating and Infection

Abstract: Bafilomycin A1 (baf), a specific inhibitor of vacuolar proton ATPases, is commonly employed to demonstrate the requirement of low endosomal pH for viral uncoating. However, in certain cell types baf also affects the transport of endocytosed material from early to late endocytic compartments. To characterize the endocytic route in HeLa cells that are frequently used to study early events in viral infection, we used 35S-labeled human rhinovirus serotype 2 (HRV2) together with various fluid-phase markers. These virions are taken up via receptor-mediated endocytosis and undergo a conformational change to C-antigenic particles at a pH of <5.6, resulting in release of the genomic RNA and ultimately in infection (E. Prchla, E. Kuechler, D. Blaas, and R. Fuchs, J. Virol. 68:3713-3723, 1994). As revealed by fluorescence microscopy and subcellular fractionation of microsomes by free-flow electrophoresis (FFE), baf arrests the transport of all markers in early endosomes. In contrast, the microtubule-disrupting agent nocodazole was found to inhibit transport by accumulating marker in endosomal carrier vesicles (ECV), a compartment intermediate between early and late endosomes. Accordingly, lysosomal degradation of HRV2 was suppressed, whereas its conformational change and infectivity remained unaffected by this drug. Analysis of the subcellular distribution of HRV2 and fluid-phase markers in the presence of nocodazole by FFE revealed no difference from the control incubation in the absence of nocodazole. ECV and late endosomes thus have identical electrophoretic mobilities, and intraluminal pHs of <5.6 and allow uncoating of HRV2. As bafilomycin not only dissipates the low endosomal pH but also blocks transport from early to late endosomes in HeLa cells, its inhibitory effect on viral infection could in part also be attributed to trapping of virus in early endosomes which might lack components essential for uncoating. Consequently, inhibition of viral uncoating by bafilomycin cannot be taken to indicate a low pH requirement only.

Inducing Human Capital Formation: Migration as a Substitute for Subsidies

Abstract: When productivity is fostered by an individual's own human capital as well as by the economy-wide average level of human capital, individuals under-invest in human capital. The provision of subsidies for the formation of human capital, conditional on the subsidy being self-financed by tax revenues, can bring the economy to its socially optimal level of human capital. Yet a strictly positive probability of migration to a richer country, by raising both the level of human capital formed by optimizing individuals in the home country and the average level of human capital of non-migrants in the country, can enhance welfare and nudge the economy toward the social optimum. Indeed, under a well-controlled, restrictive migration policy the welfare of all workers is higher than in the absence of this policy.

Adjuvant interferon alfa-2a treatment in resected primary stage II cutaneous melanoma. Austrian Malignant Melanoma Cooperative Group.

Abstract: PURPOSEPatients with primary cutaneous melanoma with a Breslow thickness > or = 1.5 mm have only a 30% to 70% probability of survival after surgery, and no adjuvant therapy has so far improved this outcome. Since interferon alfa-2a (IFNalpha2a) exhibits antitumor activity in metastatic melanoma, we investigated whether adjuvant IFNalpha2a diminishes the occurrence of metastases and thus prolongs disease-free survival in melanoma patients after excision of the primary tumor.PATIENTS AND METHODSIn a prospective randomized study, 311 melanoma patients with a Breslow thickness > or = 1.5 mm were assigned to either adjuvant IFNalpha2a treatment (n = 154) or observation (n = 157) after excision of the primary tumor. IFNalpha2a was given daily at a dose of 3 mIU subcutaneously (s.c.) for 3 weeks (induction phase), after which a dose of 3 mIU s.c. three times per week was given over 1 year (maintenance phase).RESULTSProlonged disease-free survival was observed in patients treated with IFNalpha2a versus those who ...