Institution
University of Vienna
Education•Vienna, Austria•
About: University of Vienna is a education organization based out in Vienna, Austria. It is known for research contribution in the topics: Population & Stars. The organization has 44686 authors who have published 95840 publications receiving 2907492 citations.
Topics: Population, Stars, Galaxy, Transplantation, Crystal structure
Papers published on a yearly basis
Papers
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TL;DR: Both generally agreed and controversial results about the mutational dynamics of microsatellite DNA are reviewed.
Abstract: Within the past decade microsatellites have developed into one of the most popular genetic markers. Despite the widespread use of microsatellite analysis, an integral picture of the mutational dynamics of microsatellite DNA is just beginning to emerge. Here, I review both generally agreed and controversial results about the mutational dynamics of microsatellite DNA.
789 citations
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TL;DR: Cognitive behavioural therapy (CBT) and other variants of behaviour therapy have been sufficiently investigated in controlled studies in patients with anxiety disorders, OCD, and PTSD to support them being recommended either alone or in combination with the above medicines.
Abstract: SummaryIn this report, recommendations for the pharmacological treatment of anxiety and obsessive-compulsive disorders are presented, based on available randomized, placebo-or comparator-controlled
787 citations
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TL;DR: This study provides the first evidence that a histone deacetylase is essential for unrestricted cell proliferation by repressing the expression of selective cell cycle inhibitors.
Abstract: Histone deacetylases (HDACs) modulate chromatin structure and transcription, but little is known about their function in mammalian development. HDAC1 was implicated previously in the repression of genes required for cell proliferation and differentiation. Here we show that targeted disruption of both HDAC1 alleles results in embryonic lethality before E10.5 due to severe proliferation defects and retardation in development. HDAC1‐deficient embryonic stem cells show reduced proliferation rates, which correlate with decreased cyclin‐associated kinase activities and elevated levels of the cyclin‐dependent kinase inhibitors p21 WAF1/CIP1 and p27 KIP1 . Similarly, expression of p21 and p27 is up‐regulated in HDAC1‐null embryos. In addition, loss of HDAC1 leads to significantly reduced overall deacetylase activity, hyperacetylation of a subset of histones H3 and H4 and concomitant changes in other histone modifications. The expression of HDAC2 and HDAC3 is induced in HDAC1‐deficient cells, but cannot compensate for loss of the enzyme, suggesting a unique function for HDAC1. Our study provides the first evidence that a histone deacetylase is essential for unrestricted cell proliferation by repressing the expression of selective cell cycle inhibitors.
786 citations
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University of Kent1, University of Potsdam2, University of Victoria3, Carnegie Mellon University4, Catholic University of Leuven5, Polytechnic University of Milan6, Hasso Plattner Institute7, University of Washington8, West Virginia University9, University of Vienna10, University of Paderborn11, University of Kassel12, Vanderbilt University13, George Mason University14, CA Technologies15, University of Trento16, Ludwig Maximilian University of Munich17, Bell Labs18
TL;DR: In this paper, the authors present the state-of-the-art and identify research challenges when developing, deploying and managing self-adaptive software systems, focusing on four essential topics of selfadaptation: design space for selfadaptive solutions, software engineering processes, from centralized to decentralized control, and practical run-time verification & validation.
Abstract: The goal of this roadmap paper is to summarize the state-of-the-art and identify research challenges when developing, deploying and managing self-adaptive software systems. Instead of dealing with a wide range of topics associated with the field, we focus on four essential topics of self-adaptation: design space for self-adaptive solutions, software engineering processes for self-adaptive systems, from centralized to decentralized control, and practical run-time verification & validation for self-adaptive systems. For each topic, we present an overview, suggest future directions, and focus on selected challenges. This paper complements and extends a previous roadmap on software engineering for self-adaptive systems published in 2009 covering a different set of topics, and reflecting in part on the previous paper. This roadmap is one of the many results of the Dagstuhl Seminar 10431 on Software Engineering for Self-Adaptive Systems, which took place in October 2010.
783 citations
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01 Jan 1999TL;DR: In this paper, the Toda system and the Kac-van Moerbeke system are studied. But the initial value problem is not considered in this paper, as it is in the case of Jacobi operators with periodic coefficients.
Abstract: Jacobi operators: Jacobi operators Foundations of spectral theory for Jacobi operators Qualitative theory of spectra Oscillation theory Random Jacobi operators Trace formulas Jacobi operators with periodic coefficients Reflectionless Jacobi operators Quasi-periodic Jacobi operators and Riemann theta functions Scattering theory Spectral deformations-Commutation methods Completely integrable nonlinear lattices: The Toda system The initial value problem for the Toda system The Kac-van Moerbeke system Notes on literature Compact Riemann surfaces-A review Hergoltz functions Jacobi difference equations with MathematicaR Bibliography Glossary of notations Index.
782 citations
Authors
Showing all 45262 results
Name | H-index | Papers | Citations |
---|---|---|---|
Tomas Hökfelt | 158 | 1033 | 95979 |
Wolfgang Wagner | 156 | 2342 | 123391 |
Hans Lassmann | 155 | 724 | 79933 |
Stanley J. Korsmeyer | 151 | 316 | 113691 |
Charles B. Nemeroff | 149 | 979 | 90426 |
Martin A. Nowak | 148 | 591 | 94394 |
Barton F. Haynes | 144 | 911 | 79014 |
Yi Yang | 143 | 2456 | 92268 |
Peter Palese | 132 | 526 | 57882 |
Gérald Simonneau | 130 | 587 | 90006 |
Peter M. Elias | 127 | 581 | 49825 |
Erwin F. Wagner | 125 | 375 | 59688 |
Anton Zeilinger | 125 | 631 | 71013 |
Wolfgang Waltenberger | 125 | 854 | 75841 |
Michael Wagner | 124 | 351 | 54251 |