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Institution

University of Vienna

EducationVienna, Austria
About: University of Vienna is a education organization based out in Vienna, Austria. It is known for research contribution in the topics: Population & Stars. The organization has 44686 authors who have published 95840 publications receiving 2907492 citations.


Papers
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Journal ArticleDOI
02 Nov 2012-Science
TL;DR: A method for converting the polarization state of photons into information encoded into spatial modes of a single photon is presented and entanglement of very high OAM can improve the sensitivity of angular resolution in remote sensing.
Abstract: Single photons with helical phase structures may carry a quantized amount of orbital angular momentum (OAM), and their entanglement is important for quantum information science and fundamental tests of quantum theory. Because there is no theoretical upper limit on how many quanta of OAM a single photon can carry, it is possible to create entanglement between two particles with an arbitrarily high difference in quantum number. By transferring polarization entanglement to OAM with an interferometric scheme, we generate and verify entanglement between two photons differing by 600 in quantum number. The only restrictive factors toward higher numbers are current technical limitations. We also experimentally demonstrate that the entanglement of very high OAM can improve the sensitivity of angular resolution in remote sensing.

694 citations

Journal ArticleDOI
TL;DR: The experimental evidence for the proposed mode of action of this coordination compound is discussed, including transport into the cell via the transferrin cycle and activation by reduction.
Abstract: The promising drug candidate indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) is the second Ru-based anticancer agent to enter clinical trials. In this review, which is an update of a paper from 2006 (Hartinger et al., J. Inorg. Biochem. 2006, 100, 891-904), the experimental evidence for the proposed mode of action of this coordination compound is discussed, including transport into the cell via the transferrin cycle and activation by reduction. The results of the early clinical development of KP1019 are summarized in which five out of six evaluated patients experienced disease stabilization with no severe side effects.

691 citations

Journal ArticleDOI
TL;DR: Patients with a high plasma level of factor VIII have an increased risk of recurrent venous thromboembolism, and the likelihood of recurrence at two years was higher than among patients with lower levels.
Abstract: Background A high plasma level of factor VIII is a risk factor for venous thromboembolism. We evaluated the risk of a recurrence of thrombosis after an initial episode of spontaneous venous thromboembolism among patients with high plasma levels of factor VIII. Methods We studied 360 patients for an average follow-up period of 30 months after a first episode of venous thromboembolism and discontinuation of oral anticoagulants. Patients who had recurrent or secondary venous thromboembolism, a congenital deficiency of an anticoagulant, the lupus anticoagulant, hyperhomocysteinemia, cancer, or a requirement for long-term treatment with antithrombotic drugs or who were pregnant were excluded. The end point was objectively documented, symptomatic recurrent venous thromboembolism. Results Recurrent venous thromboembolism developed in 38 of the 360 patients (10.6 percent). Patients with recurrence had higher mean (±SD) plasma levels of factor VIII than those without recurrence (182±66 vs. 157±54 IU per deciliter,...

691 citations

Journal ArticleDOI
TL;DR: BNP levels are a strong, independent predictor of sudden death in patients with CHF, and Kaplan-Meier sudden death–free survival rates were significantly higher in patients below (99%) compared with patients above (81%) this cutoff point.
Abstract: Background— Given the high incidence of sudden death in patients with chronic heart failure (CHF) and the efficacy of implantable cardioverter-defibrillators, an appropriate tool for the prediction of sudden death is desirable. B-type natriuretic peptide (BNP) has prognostic significance in CHF, and the stimuli for its production cause electrophysiological abnormalities. This study tests BNP levels as a predictor of sudden death. Methods and Results— BNP levels, in addition to other neurohormonal, clinical, and hemodynamic variables, were obtained from 452 patients with a left ventricular ejection fraction (LVEF) ≤35%. For prediction of sudden death, only survivors without heart transplantation (HTx) or a mechanical assist device and patients who died suddenly were analyzed. Up to 3 years, 293 patients survived without HTx or a mechanical assist device, 89 patients died, and 65 patients underwent HTx. Mode of death was sudden in 44 patients (49%), whereas 31 patients (35%) had pump failure and 14 patients...

687 citations

Journal ArticleDOI
TL;DR: This summary describes the consensus recommendations arising from that meeting with special emphasis on novel genetic observations and Gene expression platforms capable of detecting many of the genetic aberrations found in the clonal cells of myeloma.
Abstract: Much has been learned regarding the biology and clinical implications of genetic abnormalities in multiple myeloma. Because of recent advances in the field, an International Workshop was held in Paris in february of 2003. This summary describes the consensus recommendations arising from that meeting with special emphasis on novel genetic observations. For instance, it is increasingly clear that translocations involving the immunoglobin heavy-chain locus are important for the pathogenesis of one-half of patients. As a corollary, it also clear that the remaining patients, lacking IgH translocations, have hyperdiploidy as the hallmark of their disease. Several important genetic markers are associated with a shortened survival such as chromosome 13 monosomy, hypodiploidy, and others. The events leading the transformation of the monoclonal gammopathy of undetermined significance (MGUS) to myeloma are still unclear. One of the few differential genetic lesions between myeloma and MGUS is the presence of ras mutations in the latter. Gene expression platforms are capable of detecting many of the genetic aberrations found in the clonal cells of myeloma. Areas in need of further study were identified. The study of the genetic aberrations will likely form the platform for targeted therapy for the disease.

686 citations


Authors

Showing all 45262 results

NameH-indexPapersCitations
Tomas Hökfelt158103395979
Wolfgang Wagner1562342123391
Hans Lassmann15572479933
Stanley J. Korsmeyer151316113691
Charles B. Nemeroff14997990426
Martin A. Nowak14859194394
Barton F. Haynes14491179014
Yi Yang143245692268
Peter Palese13252657882
Gérald Simonneau13058790006
Peter M. Elias12758149825
Erwin F. Wagner12537559688
Anton Zeilinger12563171013
Wolfgang Waltenberger12585475841
Michael Wagner12435154251
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
2023419
20221,085
20214,479
20204,533
20194,225