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Institution

University of Vienna

EducationVienna, Austria
About: University of Vienna is a education organization based out in Vienna, Austria. It is known for research contribution in the topics: Population & Stars. The organization has 44686 authors who have published 95840 publications receiving 2907492 citations.


Papers
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Journal ArticleDOI
TL;DR: The first results demonstrate that the KIDSCREEN-52 questionnaire is a promising cross-cultural measure of health-related quality-of-life assessment for children and adolescents in Europe.
Abstract: This study describes the development and reports the first psychometric results of the European KIDSCREEN-52 generic health-related quality-of-life questionnaire for children and adolescents. The KIDSCREEN-52, including ten dimensions, was applied in a European survey involving 12 countries (i.e., Austria, Switzerland, Czech Republic, Germany, Greece, Spain, France, Hungary, The Netherlands, Poland, Sweden and the UK) and 22,110 children and adolescents aged between 8 and 18 years of age. Questionnaire development included a literature search, expert consultation, and focus group discussions with children and adolescents. After definition of dimensions and collection of items, a translation process following international translation guidelines, cognitive interviews and a pilot test were performed. Analysis regarding psychometric properties showed Cronbach-α ranged from 0.77 to 0.89. Correlation coefficients between KINDLR and KIDSCREEN-52 dimensions were high for those assessing similar constructs (r = 0.51-0.68). All KIDSCREEN-52 dimensions showed a gradient according to socioeconomic status and most dimensions showed a gradient according to psychosomatic health complaints. The first results demonstrate that the KIDSCREEN-52 questionnaire is a promising cross-cultural measure of health-related quality-of-life assessment for children and adolescents in Europe. © 2005 Future Drugs Ltd.

617 citations

Journal ArticleDOI
TL;DR: In this paper, Kiese et al. present a verwendung method for Registrierung physiologischer oder pharmakologischer' Wirkungen auf the Bronchialmuskulatur unter Erhaltung der natiirliehen Lungendurchblutung finden hauptsi~chlich zwei Methoden Verwendeungl: Das eine Veffahren beruht auf der Messung des Druekes in der Trachea bei gieichgehaltenem u
Abstract: Zur Registrierung physiologischer oder pharmakologischer' Wirkungen auf die Bronchialmuskulatur unter Erhaltung der natiirliehen Lungendurchblutung finden hauptsi~chlich zwei Methoden Verwendungl: Das eine Veffahren beruht auf der Messung des Druekes in der Trachea bei gieichgehaltenem u der kttnstlichen Uberdruckbeatmung. Kapazit~ts~nderungen in den Luftwegen dutch Kontraktion oder Ersehtaffung der Bronchialmuskulatur kommen bei dieser Arf. der Registrierung in einer Steigerung bzw. Senkung des intratracheal gemessenen maximalen Inspirationsdruckes (richtiger wohh Aufblasungsdruckes) zur Geltung. Bei dem anderen Verfahren wird direkt oder indirekt das Luft v o 1 u m e n ge~ messen, das die Lunge aufnimmt, wenn man den maximalen Aufblasungsdruck konstant h/~lt und dureh l~berdruekbeatmung ein gleiehbleibendes Volumen anbietet. I4apaziti~tsimderungen in den Luftwegen i~ugern sieh hier in einer Zunahme oder Abnahme der yon der Lunge unter dem gegebenen konsta.nten Aufblasungsdruck aufgenommenen Luftmenge. Die Methode der Druekmessung hat,, wie sehon Kiese ~ hervorhebt, vor allem den Naehteil, daft die Auswirkung yon Anderungen im Kontraktionszustand der Bronchialmuskulatur durch die gleichzeitigen Druckanderungen beeintriichtigt wird. Die Bronchokonstriktion ftihrt zu einer Drucksteigerung, die ihrerseits wieder der Zusammen~iehung der Bronehialmuskulatur entgegen wirken mug; umgekehrt wird eine Ersehlaffung der glatten Muskulatur in den Bronehien dureh die damit~ verbundene Druekentlastung zu einem nur unvollkommenen Erweiterungseffekt fiihren.

617 citations

Journal ArticleDOI
TL;DR: The enriched AOA, which is provisionally classified as “Candidatus Nitrososphaera gargensis,” is the first described thermophilic ammonia oxidizer and the first member of the crenarchaeotal group I.1b for which ammonium oxidation has been verified on a cellular level.
Abstract: The recent discovery of ammonia-oxidizing archaea (AOA) dramatically changed our perception of the diversity and evolutionary history of microbes involved in nitrification. In this study, a moderately thermophilic (46°C) ammonia-oxidizing enrichment culture, which had been seeded with biomass from a hot spring, was screened for ammonia oxidizers. Although gene sequences for crenarchaeotal 16S rRNA and two subunits of the ammonia monooxygenase (amoA and amoB) were detected via PCR, no hints for known ammonia-oxidizing bacteria were obtained. Comparative sequence analyses of these gene fragments demonstrated the presence of a single operational taxonomic unit and thus enabled the assignment of the amoA and amoB sequences to the respective 16S rRNA phylotype, which belongs to the widely distributed group I.1b (soil group) of the Crenarchaeota. Catalyzed reporter deposition (CARD)–FISH combined with microautoradiography (MAR) demonstrated metabolic activity of this archaeon in the presence of ammonium. This finding was corroborated by the detection of amoA gene transcripts in the enrichment. CARD-FISH/MAR showed that the moderately thermophilic AOA is highly active at 0.14 and 0.79 mM ammonium and is partially inhibited by a concentration of 3.08 mM. The enriched AOA, which is provisionally classified as “Candidatus Nitrososphaera gargensis,” is the first described thermophilic ammonia oxidizer and the first member of the crenarchaeotal group I.1b for which ammonium oxidation has been verified on a cellular level. Its preference for thermophilic conditions reinvigorates the debate on the thermophilic ancestry of AOA.

613 citations

Journal ArticleDOI
TL;DR: This editorial aims to provide practical guidance for the incorporation of absolute minimum standards encompassing the key assay parameters for accurate design, documentation and reporting of qPCR experiments (MIQE précis) and guidance on the publication of pure 'reference gene' articles.
Abstract: The conclusions of thousands of peer-reviewed publications rely on data obtained using fluorescence-based quantitative real-time PCR technology. However, the inadequate reporting of experimental detail, combined with the frequent use of flawed protocols is leading to the publication of papers that may not be technically appropriate. We take the view that this problem requires the delineation of a more transparent and comprehensive reporting policy from scientific journals. This editorial aims to provide practical guidance for the incorporation of absolute minimum standards encompassing the key assay parameters for accurate design, documentation and reporting of qPCR experiments (MIQE precis) and guidance on the publication of pure 'reference gene' articles.

612 citations

Journal ArticleDOI
TL;DR: There is a need to maintain the term genome size in a broad sense as a covering term, because it is widely understood, short and phonetically pleasing, and a new unified terminology which can describe nuclear DNA contents with ease and without ambiguity is proposed.

612 citations


Authors

Showing all 45262 results

NameH-indexPapersCitations
Tomas Hökfelt158103395979
Wolfgang Wagner1562342123391
Hans Lassmann15572479933
Stanley J. Korsmeyer151316113691
Charles B. Nemeroff14997990426
Martin A. Nowak14859194394
Barton F. Haynes14491179014
Yi Yang143245692268
Peter Palese13252657882
Gérald Simonneau13058790006
Peter M. Elias12758149825
Erwin F. Wagner12537559688
Anton Zeilinger12563171013
Wolfgang Waltenberger12585475841
Michael Wagner12435154251
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
2023419
20221,085
20214,479
20204,533
20194,225