Showing papers by "University of Virginia published in 2005"
TL;DR: An integrated research model is developed that distinguishes beliefs and attitudes about the system from beliefs about using the system to build the theoretical logic that links the user satisfaction and technology acceptance literature.
Abstract: In general, perceptions of information systems (IS) success have been investigated within two primary research streams--the user satisfaction literature and the technology acceptance literature. These two approaches have been developed in parallel and have not been reconciled or integrated. This paper develops an integrated research model that distinguishes beliefs and attitudes about the system (i.e., object-based beliefs and attitudes) from beliefs and attitudes about using the system (i.e., behavioral beliefs and attitudes) to build the theoretical logic that links the user satisfaction and technology acceptance literature. The model is then tested using a sample of 465 users from seven different organizations who completed a survey regarding their use of data warehousing software. The proposed model was supported, providing preliminary evidence that the two perspectives can and should be integrated. The integrated model helps build the bridge from design and implementation decisions to system characteristics (a core strength of the user satisfaction literature) to the prediction of usage (a core strength of the technology acceptance literature).
2,601 citations
Colorado State University1, Council of Scientific and Industrial Research2, United States Forest Service3, United States Geological Survey4, École Normale Supérieure5, University of Lyon6, Commonwealth Scientific and Industrial Research Organisation7, Lund University8, University of Dar es Salaam9, Princeton University10, University of Nairobi11, University of Virginia12, University of Cape Town13, University of Zimbabwe14, Mammal Research Institute15, University of Wisconsin-Madison16, Wageningen University and Research Centre17, University of Botswana18, University of Potsdam19, South African National Parks20
TL;DR: It is shown, using data from 854 sites across Africa, that maximum woody cover in savannas receiving a mean annual precipitation (MAP) of less than ∼650 mm is constrained by, and increases linearly with, MAP.
Abstract: Savannas are globally important ecosystems of great significance to human economies. In these biomes, which are characterized by the co-dominance of trees and grasses, woody cover is a chief determinant of ecosystem properties1–3. The availability of resources (water, nutrients) and disturbance regimes (fire, herbivory) are thought to be important in regulating woody cover1,2,4,5, but perceptions differ on which of these are the primary drivers of savanna structure. Here we show, using data from 854 sites across Africa, that maximum woody cover in savannas receiving a mean annual precipitation (MAP) of less than ,650mm is constrained by, and increases linearly with, MAP. These arid and semi-arid savannas may be considered ‘stable' systems in which water constrains woody cover and permits grasses to coexist, while fire, herbivory and soil properties interact to reduce woody cover below the MAP-controlled upper bound. Above a MAP of ,650mm, savannas are ‘unstable' systems in which MAP is sufficient for woody canopy closure, and disturbances (fire, herbivory) are required for the coexistence of trees and grass. These results provide insights into the nature of African savannas and suggest that future changes in precipitation6 may considerably affect their distribution and dynamics.
1,740 citations
Ludwig Institute for Cancer Research1, State University of Campinas2, University of Iowa3, University of Arizona4, University of New Mexico5, University of Washington6, SINTEF7, Karolinska Institutet8, Indiana University9, Johns Hopkins University School of Medicine10, University of Virginia11, McGill University12, Dartmouth College13, United States Military Academy14
TL;DR: In this paper, a double-blind placebo-controlled phase II study was done to assess the efficacy of a prophylactic quadrivalent vaccine targeting the human papillomavirus (HPV) types associated with 70% of cervical cancers (types 16 and 18) and with 90% of genital warts (types 6 and 11).
Abstract: Summary Background A randomised double-blind placebo-controlled phase II study was done to assess the efficacy of a prophylactic quadrivalent vaccine targeting the human papillomavirus (HPV) types associated with 70% of cervical cancers (types 16 and 18) and with 90% of genital warts (types 6 and 11). Methods 277 young women (mean age 20·2 years [SD 1·7]) were randomly assigned to quadrivalent HPV (20 μg type 6, 40 μg type 11, 40 μg type 16, and 20 μg type 18) L1 virus-like-particle (VLP) vaccine and 275 (mean age 20·0 years [1·7]) to one of two placebo preparations at day 1, month 2, and month 6. For 36 months, participants underwent regular gynaecological examinations, cervicovaginal sampling for HPV DNA, testing for serum antibodies to HPV, and Pap testing. The primary endpoint was the combined incidence of infection with HPV 6, 11, 16, or 18, or cervical or external genital disease (ie, persistent HPV infection, HPV detection at the last recorded visit, cervical intraepithelial neoplasia, cervical cancer, or external genital lesions caused by the HPV types in the vaccine). Main analyses were done per protocol. Findings Combined incidence of persistent infection or disease with HPV 6, 11, 16, or 18 fell by 90% (95% CI 71–97, p Interpretation A vaccine targeting HPV types 6, 11, 16, 18 could substantially reduce the acquisition of infection and clinical disease caused by common HPV types. Published online April 7, 2005 DOI 10.1016/S1470-2045(05)70101-7
1,627 citations
TL;DR: The first global assessment of amphibians provides new context for the well-publicized phenomenon of amphibian declines and shows declines are nonrandom in terms of species' ecological preferences, geographic ranges, and taxonomic associations and are most prevalent among Neotropical montane, stream-associated species.
Abstract: Using information on Brazilian species, Pimenta et al . assert that we overestimated the number of threatened amphibians. This claim, based on a misunderstanding of the IUCN-The World Conservation Union Red List criteria and a strongly evidentiary attitude to listing species, almost certainly
1,594 citations
TL;DR: Analysis of ways in which children's risk of school failure may be moderated by support from teachers found at-risk students placed in first-grade classrooms offering strong instructional and emotional support had achievement scores and student-teacher relationships commensurate with their low-risk peers.
Abstract: This study examined ways in which children's risk of school failure may be moderated by support from teachers. Participants were 910 children in a national prospective study. Children were identified as at risk at ages 5-6 years on the basis of demographic characteristics and the display of multiple functional (behavioral, attention, academic, social) problems reported by their kindergarten teachers. By the end of first grade, at-risk students placed in first-grade classrooms offering strong instructional and emotional support had achievement scores and student-teacher relationships commensurate with their low-risk peers; at-risk students placed in less supportive classrooms had lower achievement and more conflict with teachers. These findings have implications for understanding the role that classroom experience may play in pathways to positive adaptation.
1,579 citations
TL;DR: Cadherin cell-adhesion proteins mediate many facets of tissue morphogenesis, and the dynamic regulation of cadherins in response to various extracellular signals controls cell sorting, cell rearrangements and cell movements.
Abstract: Cadherin cell-adhesion proteins mediate many facets of tissue morphogenesis. The dynamic regulation of cadherins in response to various extracellular signals controls cell sorting, cell rearrangements and cell movements. Cadherins are regulated at the cell surface by an inside-out signalling mechanism that is analogous to the integrins in platelets and leukocytes. Signal-transduction pathways impinge on the catenins (cytoplasmic cadherin-associated proteins), which transduce changes across the membrane to alter the state of the cadherin adhesive bond.
1,474 citations
TL;DR: Positive psychology is the study of the conditions and processes that contribute to the flourishing or optimal functioning of people, groups, and institutions as mentioned in this paper, which is the main focus of our work.
Abstract: Positive psychology is the study of the conditions and processes that contribute to the flourishing or optimal functioning of people, groups, and institutions. In this brief introduction, the autho...
1,453 citations
TL;DR: This paper found that people often display an impact bias, overestimating the intensity and duration of their emotional reactions to negative events, and that people fail to anticipate how quickly they will cope psychologically with such events in ways that speed their recovery from them.
Abstract: People base many decisions on affective forecasts, predictions about their emotional reactions to future events. They often display an impact bias, overestimating the intensity and duration of their emotional reactions to such events. One cause of the impact bias is focalism, the tendency to underestimate the extent to which other events will influence our thoughts and feelings. Another is people's failure to anticipate how quickly they will make sense of things that happen to them in a way that speeds emotional recovery. This is especially true when predicting reactions to negative events: People fail to anticipate how quickly they will cope psychologically with such events in ways that speed their recovery from them. Several implications are discussed, such as the tendency for people to attribute their unexpected resilience to external agents.
1,443 citations
TL;DR: In this paper, a combination of experimental and simulation techniques were used to investigate the plastic behavior of wrought magnesium alloy and found that an increased activity of non-basal dislocations provides a self-consistent explanation for the observed changes in the anisotropy with increasing temperature.
1,427 citations
TL;DR: In this paper, the authors investigated the pathway upstream of integrin activation and found that PECAM-1 and VEGFR2 are sufficient to confer responsiveness to flow in heterologous cells.
Abstract: Shear stress is a fundamental determinant of vascular homeostasis, regulating vascular remodelling, cardiac development and atherogenesis, but the mechanisms of transduction are poorly understood. Previous work showed that the conversion of integrins to a high-affinity state mediates a subset of shear responses, including cell alignment and gene expression. Here we investigate the pathway upstream of integrin activation. PECAM-1 (which directly transmits mechanical force), vascular endothelial cell cadherin (which functions as an adaptor) and VEGFR2 (which activates phosphatidylinositol-3-OH kinase) comprise a mechanosensory complex. Together, these receptors are sufficient to confer responsiveness to flow in heterologous cells. In support of the relevance of this pathway in vivo, PECAM-1-knockout mice do not activate NF-kappaB and downstream inflammatory genes in regions of disturbed flow. Therefore, this mechanosensing pathway is required for the earliest-known events in atherogenesis.
1,387 citations
TL;DR: Eukaryotic cells contain various Ca2-effector proteins that mediate cellular responses to changes in intracellular Ca2+ levels, and a unique class of these proteins — annexins — can bind to certain membrane phospholipids in a Ca2+.
Abstract: Eukaryotic cells contain various Ca(2+)-effector proteins that mediate cellular responses to changes in intracellular Ca(2+) levels. A unique class of these proteins - annexins - can bind to certain membrane phospholipids in a Ca(2+)-dependent manner, providing a link between Ca(2+) signalling and membrane functions. By forming networks on the membrane surface, annexins can function as organizers of membrane domains and membrane-recruitment platforms for proteins with which they interact. These and related properties enable annexins to participate in several otherwise unrelated events that range from membrane dynamics to cell differentiation and migration.
TL;DR: The aim of the American Thoracic Society/European Respiratory Society Task Force on EBC was to identify the important methodological issues surrounding EBC collection and assay, to provide recommendations for the measurements and to highlight areas where further research is required.
Abstract: Collection of exhaled breath condensate (EBC) is a noninvasive method for obtaining samples from the lungs. EBC contains large number of mediators including adenosine, ammonia, hydrogen peroxide, isoprostanes, leukotrienes, nitrogen oxides, peptides and cytokines. Concentrations of these mediators are influenced by lung diseases and modulated by therapeutic interventions. Similarly EBC pH also changes in respiratory diseases. The aim of the American Thoracic Society/European Respiratory Society Task Force on EBC was to identify the important methodological issues surrounding EBC collection and assay, to provide recommendations for the measurements and to highlight areas where further research is required. Based on the currently available evidence and the consensus of the expert panel for EBC collection, the following general recommendations were put together for oral sample collection: collect during tidal breathing using a noseclip and a saliva trap; define cooling temperature and collection time (10 min is generally sufficient to obtain 1-2 mL of sample and well tolerated by patients); use inert material for condenser; do not use resistor and do not use filter between the subject and the condenser. These are only general recommendations and certain circumstances may dictate variation from them. Important areas for future research involve: ascertaining mechanisms and site of exhaled breath condensate particle formation; determination of dilution markers; improving reproducibility; employment of EBC in longitudinal studies; and determining the utility of exhaled breath condensate measures for the management of individual patients. These studies are required before recommending this technique for use in clinical practice.
TL;DR: The electromagnetic interference (EMI) shielding effectiveness measurements indicated that a novel carbon nanotube-polystyrene foam composite can be used as very effective, lightweight shielding materials.
Abstract: A novel carbon nanotube-polystyrene foam composite has been fabricated successfully. The electromagnetic interference (EMI) shielding effectiveness measurements indicated that such foam composites can be used as very effective, lightweight shielding materials. The correlation between the shielding effectiveness and electrical conductivity and the EMI shielding mechanism of such foam composites are also discussed.
TL;DR: In four studies, analyses of data from 11 Web IATs supported the following conclusions: (a) sorting IAT trials into subsets does not yield conceptually distinct measures; (b) valid IAT measures can be produced using as few as two items to represent each concept; and (c) a known extraneous effect of IAT task block order was sharply reduced by using extra practice trials.
Abstract: The Implicit Association Test (IAT) assesses relative strengths of four associations involving two pairs of contrasted concepts (e.g., male-female and family-career). In four studies, analyses of data from 11 Web IATs, averaging 12,000 respondents per data set, supported the following conclusions: (a) sorting IAT trials into subsets does not yield conceptually distinct measures; (b) valid IAT measures can be produced using as few as two items to represent each concept; (c) there are conditions for which the administration order of IAT and self-report measures does not alter psychometric properties of either measure; and (d) a known extraneous effect of IAT task block order was sharply reduced by using extra practice trials. Together, these analyses provide additional construct validation for the IAT and suggest practical guidelines to users of the IAT.
TL;DR: It is shown that HP1α, -β, and -γ are released from chromatin during the M phase of the cell cycle, even though tri-methylation levels of histone H3 lysine 9 remain unchanged, and a regulatory mechanism of protein–protein interactions is established through a combinatorial readout of two adjacent post-translational modifications: a stable methylation and a dynamic phosphorylation mark.
Abstract: Tri-methylation of histone H3 lysine 9 is important for recruiting heterochromatin protein 1 (HP1) to discrete regions of the genome, thereby regulating gene expression, chromatin packaging and heterochromatin formation Here we show that HP1α, -β, and -γ are released from chromatin during the M phase of the cell cycle, even though tri-methylation levels of histone H3 lysine 9 remain unchanged However, the additional, transient modification of histone H3 by phosphorylation of serine 10 next to the more stable methyl-lysine 9 mark is sufficient to eject HP1 proteins from their binding sites Inhibition or depletion of the mitotic kinase Aurora B, which phosphorylates serine 10 on histone H3, causes retention of HP1 proteins on mitotic chromosomes, suggesting that H3 serine 10 phosphorylation is necessary for the dissociation of HP1 from chromatin in M phase These findings establish a regulatory mechanism of protein–protein interactions, through a combinatorial readout of two adjacent post-translational modifications: a stable methylation and a dynamic phosphorylation mark
TL;DR: Kiss1 gene encodes a family of neuropeptides called kisspeptins, which activate the receptor G protein-coupled receptor-54 and play a role in the neuroendocrine regulation of GnRH secretion and whether estradiol regulates KiSS-1 in the forebrain of the female mouse is examined.
Abstract: The Kiss1 gene encodes a family of neuropeptides called kisspeptins, which activate the receptor G protein-coupled receptor-54 and play a role in the neuroendocrine regulation of GnRH secretion. We examined whether estradiol (E2) regulates KiSS-1 in the forebrain of the female mouse by comparing KiSS-1 mRNA expression among groups of ovary-intact (diestrus), ovariectomized (OVX), and OVX plus E2-treated mice. In the arcuate nucleus (Arc), KiSS-1 expression increased after ovariectomy and decreased with E2 treatment. Conversely, in the anteroventral periventricular nucleus (AVPV), KiSS-1 expression was reduced after ovariectomy and increased with E2 treatment. To determine whether the effects of E2 on KiSS-1 are mediated through estrogen receptor (ER)alpha or ERbeta, we evaluated the effects of E2 in OVX mice that lacked functional ERalpha or ERbeta. In OVX mice that lacked functional ERalpha, KiSS-1 mRNA did not respond to E2 in either the Arc or AVPV, suggesting that ERalpha is essential for mediating the inhibitory and stimulatory effects of E2. In contrast, KiSS-1 mRNA in OVX mice that lacked functional ERbeta responded to E2 exactly as wild-type animals. Double-label in situ hybridization revealed that virtually all KiSS-1-expressing neurons in the Arc and AVPV coexpress ERalpha, suggesting that the effects of E2 are mediated directly through KiSS-1 neurons. We conclude that KiSS-1 neurons in the Arc, which are inhibited by E2, may play a role in the negative feedback regulation of GnRH secretion, whereas KiSS-1 neurons in the AVPV, which are stimulated by E2, may participate in the positive feedback regulation of GnRH secretion.
TL;DR: A necessary and sufficient condition for an S-procedure to be lossless is developed, and the result is used to generalize the KYP lemma in two aspects-the frequency range and the class of systems-and to unify various existing versions by a single theorem.
Abstract: The celebrated Kalman-Yakubovic/spl caron/-Popov (KYP) lemma establishes the equivalence between a frequency domain inequality (FDI) and a linear matrix inequality, and has played one of the most fundamental roles in systems and control theory. This paper first develops a necessary and sufficient condition for an S-procedure to be lossless, and uses the result to generalize the KYP lemma in two aspects-the frequency range and the class of systems-and to unify various existing versions by a single theorem. In particular, our result covers FDIs in finite frequency intervals for both continuous/discrete-time settings as opposed to the standard infinite frequency range. The class of systems for which FDIs are considered is no longer constrained to be proper, and nonproper transfer functions including polynomials can also be treated. We study implications of this generalization, and develop a proper interface between the basic result and various engineering applications. Specifically, it is shown that our result allows us to solve a certain class of system design problems with multiple specifications on the gain/phase properties in several frequency ranges. The method is illustrated by numerical design examples of digital filters and proportional-integral-derivative controllers.
University of Virginia1, University of Wisconsin-Madison2, Space Science Institute3, University of Maryland, College Park4, University of California, Berkeley5, Boston University6, University of Minnesota7, University of Wyoming8, European Space Research and Technology Centre9, California Institute of Technology10
TL;DR: In this paper, the extinction ratio between two of the filters, e.g., AJ/AK, is required to calculate A[λ]/AK from those measured ratios, which shows a flattening across the 3-8 μm wavelength range, roughly consistent with the extinction measurements derived by Lutz and coworkers for the sight line toward the Galactic center.
Abstract: We determine and tabulate A[λ]/AK, the wavelength dependence of interstellar extinction, in the Galactic plane for 1.25 μm ≤ λ ≤ 8.0 μm along two lines of sight: l = 42° and 284°. The first is a relatively quiescent and unremarkable region; the second contains the giant H II region RCW 49, as well as a "field" region unrelated to the cluster and nebulosity. Areas near these Galactic longitudes were imaged at J, H, and K bands by 2MASS and at 3-8 μm by Spitzer for the GLIMPSE Legacy program. We measure the mean values of the color excess ratios (A[λ] - AK)/(AJ - AK) directly from the color distributions of observed stars. The extinction ratio between two of the filters, e.g., AJ/AK, is required to calculate A[λ]/AK from those measured ratios. We use the apparent JHK magnitudes of giant stars along our two sight lines and fit the reddening as a function of magnitude (distance) to determine AJ kpc-1, AK kpc-1, and AJ/AK. Our values of A[λ]/AK show a flattening across the 3-8 μm wavelength range, roughly consistent with the extinction measurements derived by Lutz and coworkers for the sight line toward the Galactic center.
TL;DR: A model consisting of nine fundamental determinants of quality in an information technology context, four under the rubric of information quality and five that describe system quality are developed, suggesting that the determinants are indeed predictive of overall information and system quality in data warehouse environments.
Abstract: Understanding the successful adoption of information technology is largely based upon understanding the linkages among quality, satisfaction, and usage. Although the satisfaction and usage constructs have been well studied in the information systems literature, there has been only limited attention to information and system quality over the past decade. To address this shortcoming, we developed a model consisting of nine fundamental determinants of quality in an information technology context, four under the rubric of information quality (the output of an information system) and five that describe system quality (the information processing system required to produce the output). We then empirically examined the aptness of our model using a sample of 465 data warehouse users from seven different organizations that employed report-based, query-based, and analytical business intelligence tools. The results suggest that our determinants are indeed predictive of overall information and system quality in data warehouse environments, and that our model strikes a balance between comprehensiveness and parsimony. We conclude with a discussion of the implications for both theory and the development and implementation of information technology applications in practice.
TL;DR: It is shown that IL-17, a cytokine that regulates granulopoiesis through G-CSF, is made by gammadelta T cells and unconventional alphabeta T cells, which are expanded in mice that lack leukocyte adhesion molecules, which have neutrophilia and defective neutrophil trafficking.
TigerLogic1, Wellcome Trust2, University of Newcastle3, Boston University4, University of Virginia5, National Institutes of Health6, Medical University of Vienna7, University of London8, Bernhard Nocht Institute for Tropical Medicine9, University of Kiel10, Jawaharlal Nehru University11, Pasteur Institute12, Bose Institute13, Natural History Museum14, Technical University of Denmark15, Stanford University16
TL;DR: The genome of E. histolytica is presented, which reveals a variety of metabolic adaptations shared with two other amitochondrial protist pathogens: Giardia lamblia and Trichomonas vaginalis, and provides new insights into the workings and genome evolution of a major human pathogen.
Abstract: Entamoeba histolytica is an intestinal parasite and the causative agent of amoebiasis, which is a significant source of morbidity and mortality in developing countries. Here we present the genome of E. histolytica, which reveals a variety of metabolic adaptations shared with two other amitochondrial protist pathogens: Giardia lamblia and Trichomonas vaginalis. These adaptations include reduction or elimination of most mitochondrial metabolic pathways and the use of oxidative stress enzymes generally associated with anaerobic prokaryotes. Phylogenomic analysis identifies evidence for lateral gene transfer of bacterial genes into the E. histolytica genome, the effects of which centre on expanding aspects of E. histolytica's metabolic repertoire. The presence of these genes and the potential for novel metabolic pathways in E. histolytica may allow for the development of new chemotherapeutic agents. The genome encodes a large number of novel receptor kinases and contains expansions of a variety of gene families, including those associated with virulence. Additional genome features include an abundance of tandemly repeated transfer-RNA-containing arrays, which may have a structural function in the genome. Analysis of the genome provides new insights into the workings and genome evolution of a major human pathogen.
TL;DR: The unique characteristics of the Bcc are highlighted, focusing on the factors that determine virulence, and some members can also degrade natural and man-made pollutants.
Abstract: The Burkholderia cepacia complex (Bcc) is a collection of genetically distinct but phenotypically similar bacteria that are divided into at least nine species. Bcc bacteria are found throughout the environment, where they can have both beneficial and detrimental effects on plants and some members can also degrade natural and man-made pollutants. Bcc bacteria are now recognized as important opportunistic pathogens that can cause variable lung infections in cystic fibrosis patients, which result in asymptomatic carriage, chronic infection or 'cepacia syndrome', which is characterized by a rapid decline in lung function that can include invasive disease. Here we highlight the unique characteristics of the Bcc, focusing on the factors that determine virulence.
TL;DR: Two studies show that moral judgments can be made more severe by the presence of a flash of disgust, and suggest thatmoral judgments may be grounded in affectively laden moral intuitions.
Abstract: Highly hypnotizable participants were given a posthypnotic suggestion to feel a flash of disgust whenever they read an arbitrary word. They were then asked to rate moral transgressions described in vignettes that either did or did not include the disgust-inducing word. Two studies show that moral judgments can be made more severe by the presence of a flash of disgust. These findings suggest that moral judgments may be grounded in affectively laden moral intuitions.
TL;DR: Several of the major transport pathways that are conserved in higher and lower eukaryotes are described, with particular emphasis on the role of Ran.
Abstract: Nuclear transport of proteins and RNA occurs through the nuclear pore complex and is mediated by a superfamily of transport receptors known collectively as karyopherins. Karyopherins bind to their cargoes by recognition of specific nuclear localization signals or nuclear export signals. Transport through the nuclear pore complex is facilitated by transient interactions between the karyopherins and the nuclear pore complex. The interactions of karyopherins with their cargoes are regulated by the Ras-related GTPase Ran. Ran is assisted in this process by proteins that regulate its GTPase cycle and subcellular localization. In this review, we describe several of the major transport pathways that are conserved in higher and lower eukaryotes, with particular emphasis on the role of Ran. We highlight the latest advances in the structure and function of transport receptors and discuss recent examples of steroid hormone receptor import and regulation by signal transduction pathways. Understanding the molecular basis of nuclear transport may provide insight into human diseases by revealing how nucleocytoplasmic trafficking regulates protein activity.
TL;DR: The widening application of FRET and FLIM has been driven by the availability of suitable fluorophores, increasingly sophisticated microscopy systems, methodologies to correct spectral bleed-through, and the ease with which FRET can be combined with other techniques.
TL;DR: In this article, an extensive set of volatile organic compounds (VOCs) and particulate organic matter (POM) was measured in polluted air during the New England Air Quality Study in 2002.
Abstract: [1] An extensive set of volatile organic compounds (VOCs) and particulate organic matter (POM) was measured in polluted air during the New England Air Quality Study in 2002. Using VOC ratios, the photochemical age of the sampled air masses was estimated. This approach was validated (1) by comparing the observed rates at which VOCs were removed from the atmosphere with the rates expected from OH oxidation, (2) by comparing the VOC emission ratios inferred from the data with the average composition of urban air, and (3) by the ability to describe the increase of an alkyl nitrate with time in terms of the chemical kinetics. A large part of the variability observed for oxygenated VOCs (OVOCs) and POM could be explained by a description that includes the removal of the primary anthropogenic emissions, the formation and removal of secondary anthropogenic species, and a biogenic contribution parameterized by the emissions of isoprene. The OVOC sources determined from the data are compared with the available literature, and a satisfactory agreement is obtained. The observed sub-μm POM was highly correlated with secondary anthropogenic gas-phase species, strongly suggesting that the POM was from secondary anthropogenic sources. The results are used to describe the speciation and total mass of gas- and particle-phase organic carbon as a function of the photochemical age of an urban air mass. Shortly after emission the organic carbon mass is dominated by primary VOCs, while after two days the dominant contribution is from OVOCs and sub-μm POM. The total measured organic carbon mass decreased by about 40% over the course of two days. The increase in sub-μm POM could not be explained by the removal of aromatic precursors alone, suggesting that other species must have contributed and/or that the mechanism for POM formation is more efficient than previously assumed.
TL;DR: This work has shown that during late mitosis and G1, replication origins are 'licensed' for replication by loading the minichromosome maintenance (Mcm) 2–7 proteins to form a pre-replicative complex.
Abstract: To ensure its duplication, chromosomal DNA must be precisely duplicated in each cell cycle, with no sections left unreplicated, and no sections replicated more than once. Eukaryotic cells achieve this by dividing replication into two non-overlapping phases. During late mitosis and G1, replication origins are 'licensed' for replication by loading the minichromosome maintenance (Mcm) 2-7 proteins to form a pre-replicative complex. Mcm2-7 proteins are then essential for initiating and elongating replication forks during S phase. Recent data have provided biochemical and structural insight into the process of replication licensing and the mechanisms that regulate it during the cell cycle.
TL;DR: Evidence is presented for 4 moderators of the relationship between automatic (implicit) and controlled (explicit) evaluations: self-presentation, evaluative strength, dimensionality, and distinctiveness, which moderated implicit-explicit correspondence across individuals and accounted for much of the observed variation across content domains.
Abstract: Automatic and controlled modes of evaluation sometimes provide conflicting reports of the quality of social objects. This article presents evidence for 4 moderators of the relationship between automatic (implicit) and controlled (explicit) evaluations. Implicit and explicit preferences were measured for a variety of object pairs using a large sample. The average correlation was r=.36, and 52 of the 57 object pairs showed a significant positive correlation. Results of multilevel modeling analyses suggested that (a) implicit and explicit preferences are related, (b) the relationship varies as a function of the objects assessed, and (c) at least 4 variables moderate the relationship: self-presentation, evaluative strength, dimensionality, and distinctiveness. The variables moderated implicit-explicit correspondence across individuals and accounted for much of the observed variation across content domains. The resulting model of the relationship between automatic and controlled evaluative processes is grounded in personal experience with the targets of evaluation.
Icahn School of Medicine at Mount Sinai1, Food and Drug Administration2, American College of Emergency Physicians3, Stanford University4, Johns Hopkins University5, University of Texas Southwestern Medical Center6, American Academy of Pediatrics7, Harvard University8, University of Pennsylvania9, Medical University of South Carolina10, National Institutes of Health11, University of Virginia12, National Health Service13, University of Manitoba14
TL;DR: This dissertation aims to provide a history of medical marijuana use in the United States and Canada over a 40-year period from 1989 to 2002, with a focus on the period up to and including the year ending in 2002.
Abstract: Hugh A. Sampson, MD, Anne Munoz-Furlong, BA, S. Allan Bock, MD, Cara Schmitt, MS, Robert Bass, MD, Badrul A. Chowdhury, MD, Wyatt W. Decker, MD, Terence J. Furlong, MS, Stephen J. Galli, MD, David B. Golden, MD, Rebecca S. Gruchalla, MD, Allen D. Harlor, Jr, MD, David L. Hepner, MD, Marilyn Howarth, MD, Allen P. Kaplan, MD, Jerrold H. Levy, MD, Lawrence M. Lewis, MD, Phillip L. Lieberman, MD, Dean D. Metcalfe, MD, Ramon Murphy, MD, Susan M. Pollart, MD, Richard S. Pumphrey, MD, Lanny J. Rosenwasser, MD, F. Estelle Simons, MD, Joseph P. Wood, MD, and Carlos A. Camargo, Jr, MD New York, NY, Fairfax and Charlottesville, Va, Boulder and Denver, Colo, Baltimore, Rockville, and Bethesda, Md, Rochester, Minn, Stanford, Calif, Dallas, Tex, Eugene, Ore, Boston, Mass, Philadelphia, Pa, Charleston, SC, Atlanta, Ga, St Louis, Mo, Cordova, Tenn, Scottsdale, Ariz, Manchester, United Kingdom, and Winnipeg, Manitoba, Canada
TL;DR: In this paper, the authors introduce a two-dimensional framework to further the understanding of public sector corruption and identify its implications for multinational enterprises (MNEs) using an institutional perspective.
Abstract: Multinational enterprises (MNEs) often encounter government corruption when operating in host countries; however, in the international management literature, it is typically assumed that government officials pursue national interests rather than their own. We introduce a two-dimensional framework to further the understanding of public sector corruption and identify its implications for MNEs. Using an institutional perspective, we examine how the pervasiveness and arbitrariness of corruption can affect an MNE's organizational legitimacy and strategic decision making. We apply our analysis to the mode of entry decision.