University of Virginia

About: University of Virginia is a education organization based out in Charlottesville, Virginia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 52543 authors who have published 113268 publications receiving 5220506 citations. The organization is also known as: U of V & UVa.

Characteristics of partnership success: Partnership attributes, communication behavior, and conflict resolution techniques

Abstract: The formation of partnerships between firms is becoming an increasingly common way for firms to find and maintain competitive advantage. While the antecedents of partnership formation and the characteristics of the resulting cooperative working relationship have been explored in the literature, an understanding of characteristics associated with partnership success is lacking. Such an understanding is important in reconciling the prescriptions to form partnerships with the reality that a majority of such partnerships do not succeed. We hypothesize that partnership attributes, communication behavior, and conflict resolution techniques are related to indicators of partnership success (satisfaction and sales volume in the relationship). The hypotheses are tested with vertical partnerships between manufacturers and dealers. Results indicate that the primary characteristics of partnership success are: partnership attributes of commitment, coordination, and trust; communication quality and participation; and the conflict resolution technique of joint problem solving. The findings offer insight into how to better manage these relationships to ensure success.

High frequency of mutations of the PIK3CA gene in human cancers

Abstract: Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate signaling pathways important for neoplasia, including cell proliferation, adhesion, survival, and motility ([ 1 ][1]–[ 3 ][2]). To determine if PI3Ks are genetically altered in tumorigenesis, we sequenced PI3K genes in human

A two-solar-mass neutron star measured using Shapiro delay

Abstract: Neutron stars comprise the densest form of matter known to exist in our Universe, but their composition and properties are uncertain. Measurements of their masses and radii can constrain theoretical predictions of their composition, but so far it has not been possible to rule out many predictions of 'exotic' non-nucleonic components. Here, radio timing observations of the binary millisecond pulsar J1614-2230 are presented, allowing almost all currently proposed hyperon or boson condensate equations of state to be ruled out.

A massive pulsar in a compact relativistic binary

Abstract: Many physically motivated extensions to general relativity (GR) predict significant deviations at energies present in massive neutron stars. We report the measurement of a 2.01 \(\pm \) 0.04 solar mass (M\(_\odot \)) pulsar in a 2.46-h orbit around a 0.172 \(\pm \) 0.003 M\(_\odot \) white dwarf. The high pulsar mass and the compact orbit make this system a sensitive laboratory of a previously untested strong-field gravity regime. Thus far, the observed orbital decay agrees with GR, supporting its validity even for the extreme conditions present in the system. The resulting constraints on deviations support the use of GR-based templates for ground-based gravitational wave detection experiments. Additionally, the system strengthens recent constraints on the properties of dense matter and provides novel insight to binary stellar astrophysics and pulsar recycling.

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.

Abstract: IPEX is a fatal disorder characterized by immune dysregulation, polyendocrinopathy, enteropathy and X-linked inheritance (MIM 304930). We present genetic evidence that different mutations of the human gene FOXP3, the ortholog of the gene mutated in scurfy mice (Foxp3), causes IPEX syndrome. Recent linkage analysis studies mapped the gene mutated in IPEX to an interval of 17-20-cM at Xp11. 23-Xq13.3.