Institution
University of Virginia
Education•Charlottesville, Virginia, United States•
About: University of Virginia is a education organization based out in Charlottesville, Virginia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 52543 authors who have published 113268 publications receiving 5220506 citations. The organization is also known as: U of V & UVa.
Topics: Population, Poison control, Galaxy, Health care, Star formation
Papers published on a yearly basis
Papers
More filters
••
TL;DR: The development and use of expression vectors based on three of the most frequently used gene fusion affinity tags are discussed with respect to overcoming purification problems encountered for the RhoA GDP/GTP nucleotide dissociation inhibitor (RhoGDI) and their advantages over commercially available expression vectors.
625 citations
••
TL;DR: This link facilitates the derivation of powerful identifiability results for MI-SAP, shows that the uniqueness of single- and multiple-invariance ESPRIT stems from uniqueness of low-rank decomposition of three-way arrays, and allows tapping on the available expertise for fitting the PARAFAC model.
Abstract: This paper links multiple invariance sensor array processing (MI-SAP) to parallel factor (PARAFAC) analysis, which is a tool rooted in psychometrics and chemometrics. PARAFAC is a common name for low-rank decomposition of three- and higher way arrays. This link facilitates the derivation of powerful identifiability results for MI-SAP, shows that the uniqueness of single- and multiple-invariance ESPRIT stems from uniqueness of low-rank decomposition of three-way arrays, and allows tapping on the available expertise for fitting the PARAFAC model. The results are applicable to both data-domain and subspace MI-SAP formulations. The paper also includes a constructive uniqueness proof for a special PARAFAC model.
625 citations
••
TL;DR: A mechanism by which the insulator in the β-globin locus can protect the globin genes from being silenced by adjacent condensed chromatin is proposed.
Abstract: Methylation of histones at specific residues plays an important role in transcriptional regulation. Chromatin immunoprecipitation of dimethylated lysine 9 on histone H3 across 53 kilobases of the chicken β-globin locus during erythropoiesis shows an almost complete anticorrelation between regions of elevated lysine 9 methylation and acetylation. Lysine 9 is methylated most over constitutive condensed chromatin and developmentally inactive globin genes. In contrast, lysine 4 methylation of histone H3 correlates with H3 acetylation. These results lead us to propose a mechanism by which the insulator in the β-globin locus can protect the globin genes from being silenced by adjacent condensed chromatin.
625 citations
••
TL;DR: This is the first prospective, multiinstitutional, nationwide, clinically rich, bariatric-specific data comparing sleeve gastrectomy to the adjustable gastric band, and the gastric bypass and LSG has morbidity and effectiveness positioned between the LAGB and the LRYGB/ORYGB for data up to 1 year.
Abstract: Objective:To assess the safety and effectiveness of the laparoscopic sleeve gastrectomy (LSG) as compared to the laparoscopic adjustable gastric band (LAGB), the laparoscopic Roux-en-Y gastric bypass (LRYGB) and the open Roux-en-Y gastric bypass (ORYGB) for the treatment of obesity and obesity-relat
624 citations
••
TL;DR: Several new factors that regulate engulfment have been identified, whereas the roles of some of the older players require revision.
Abstract: The clearance of apoptotic cells by phagocytes is an integral component of normal life, and defects in this process can have significant implications for self tolerance and autoimmunity. Recent studies have provided new insights into the engulfment process, including how phagocytes seek apoptotic cells, how they recognize and ingest these targets and how they maintain cellular homeostasis after the 'meal'. Several new factors that regulate engulfment have been identified, whereas the roles of some of the older players require revision. This Review focuses on these recent developments and attempts to highlight some of the important questions in this field.
624 citations
Authors
Showing all 53083 results
Name | H-index | Papers | Citations |
---|---|---|---|
Joan Massagué | 189 | 408 | 149951 |
Michael Rutter | 188 | 676 | 151592 |
Gordon B. Mills | 187 | 1273 | 186451 |
Ralph Weissleder | 184 | 1160 | 142508 |
Gonçalo R. Abecasis | 179 | 595 | 230323 |
Jie Zhang | 178 | 4857 | 221720 |
John R. Yates | 177 | 1036 | 129029 |
John A. Rogers | 177 | 1341 | 127390 |
Bradley Cox | 169 | 2150 | 156200 |
Mika Kivimäki | 166 | 1515 | 141468 |
Hongfang Liu | 166 | 2356 | 156290 |
Carl W. Cotman | 165 | 809 | 105323 |
Ralph A. DeFronzo | 160 | 759 | 132993 |
Elio Riboli | 158 | 1136 | 110499 |
Dan R. Littman | 157 | 426 | 107164 |