University of Virginia

About: University of Virginia is a education organization based out in Charlottesville, Virginia, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 52543 authors who have published 113268 publications receiving 5220506 citations. The organization is also known as: U of V & UVa.

Effects of Poverty and Maternal Depression on Early Child Development

Abstract: Researchers have renewed an interest in the harmful consequences of poverty on child development. This study builds on this work by focusing on one mechanism that links material hardship to child outcomes, namely the mediating effect of maternal depression. Using data from the National Maternal and Infant Health Survey, we found that maternal depression and poverty jeopardized the development of very young boys and girls, and to a certain extent, affluence buffered the deleterious consequences of depression. Results also showed that chronic maternal depression had severe implications for both boys and girls, whereas persistent poverty had a strong effect for the development of girls. The measures of poverty and maternal depression used in this study generally had a greater impact on measures of cognitive development than motor development.

Understanding fit and appropriation effects in group support systems via meta-analysis

Abstract: Many previous papers have lamented the fact that the findings of past GSS research have been inconsistent. This paper develops a new model for interpreting GSS effects on performance (a Fit-Appropriation Model), which argues that GSS performance is affected by two factors. The first is the fit between the task and the GSS structures selected for use (i.e., communication support and information processing support). The second is the appropriation support the group receives in the form of training, facilitation, and software restrictiveness to help them effectively incorporate the selected GSS structures into their meeting process. A meta-analysis using this model to organize and classify past research found that when used appropriately (i.e., there is a fit between the GSS structures and the task, and the group receives appropriation support), GSS use increased the number of ideas generated, took less time, and led to more satisfied participants than if the group worked without the GSS. Fitting the GSS to the task had the most impact on outcome effectiveness (decision quality and ideas), while appropriation support had the most impact on the process (time required and process satisfaction). We conclude that when using this theoretical lens, the results of GSS research do not appear inconsistent.

Numerical models of salt marsh evolution: Ecological, geomorphic, and climatic factors

Abstract: Salt marshes are delicate landforms at the boundary between the sea and land. These ecosystems support a diverse biota that modifies the erosive characteristics of the substrate and mediates sediment transport processes. Here we present a broad overview of recent numerical models that quantify the formation and evolution of salt marshes under different physical and ecological drivers. In particular, we focus on the coupling between geomorphological and ecological processes and on how these feedbacks are included in predictive models of landform evolution. We describe in detail models that simulate fluxes of water, organic matter, and sediments in salt marshes. The interplay between biological and morphological processes often produces a distinct scarp between salt marshes and tidal flats. Numerical models can capture the dynamics of this boundary and the progradation or regression of the marsh in time. Tidal channels are also key features of the marsh landscape, flooding and draining the marsh platform and providing a source of sediments and nutrients to the marsh ecosystem. In recent years, several numerical models have been developed to describe the morphogenesis and long-term dynamics of salt marsh channels. Finally, salt marshes are highly sensitive to the effects of long-term climatic change. We therefore discuss in detail how numerical models have been used to determine salt marsh survival under different scenarios of sea level rise.

RANTES Deposition by Platelets Triggers Monocyte Arrest on Inflamed and Atherosclerotic Endothelium

Abstract: Background—Circulating platelets and chemoattractant proteins, such as the CC chemokine RANTES, contribute to the activation and interaction of monocytes and endothelium and may thereby play a pivotal role in the pathogenesis of inflammatory and atherosclerotic disease. Methods and Results—The binding of RANTES to human endothelial cells was detected by ELISA or immunofluorescence after perfusion with platelets or exposure to their supernatants. Monocyte arrest on endothelial monolayers or surface-adherent platelets was studied with a parallel-wall flow chamber and video microscopy. We show that RANTES secreted by thrombin-stimulated platelets is immobilized on the surface of inflamed microvascular or aortic endothelium and triggers shear-resistant monocyte arrest under flow conditions, as shown by inhibition with the RANTES receptor antagonist Met-RANTES or a blocking RANTES antibody. Deposition of RANTES and its effects requires endothelial activation, eg, by interleukin-1β, and is not supported by veno...